The dark side of DNA - how the immune system senses DNA as a danger signal
Zhijian “ James ” Chen ’ s research into complex cellular biochemistry has led to the discovery of pathways and proteins that trigger immune and stress responses. Chen has identified proteins, such as the mitochondrial protein MAVS, that are crucial to the body ’ s defense against RNA viruses such as influenza and Ebola. Now, Chen and his team are dissecting a signaling pathway involving a novel DNA sensor – cyclic GMP-AMP (cGAMP) synthase, or cGAS – which activates an interferon response that may play a role in immune defense against pathogens and malignant cells, as well as in autoimmune diseases such as lupu...
Source: Videocast - All Events - July 26, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Evolutionary Dynamics of SARS-CoV-2
This is the annual Dewitt Stetten Jr. Lecture. Speaker Trevor Bedford, Ph.D., is Associate Professor, Vaccine and Infectious Disease Division; Associate Professor, Herbold Computational Biology Program; and Associate Professor, Human Biology Division, Fred Hutch. Bedford uses powerful computers and complex statistical methods to study the rapid spread and evolution of viruses, including those that cause COVID-19, influenza, Ebola and Zika. Data gathered from these processes help researchers develop successful strategies for monitoring and controlling infectious diseases.For more information go tohttps://oir.nih.gov/walsAir...
Source: Videocast - All Events - September 8, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
The Biomedical Research Response to COVID-19: A View from NIAID
NIH COVID-19 SIG Lecture Series
NIAID has a long-standing dual mandate to maintain a robust portfolio of research in its key focus areas and to respond to emerging and re-emerging infectious diseases (EIDs). With this mandate, NIAID has also sought to improve EID-response preparedness, working in partnership with other U.S. government research entities, industry, academia, and international public-health organizations. This preparedness planning helped the institute respond rapidly to COVID-19. NIAID tapped existing coronavirus expertise and other assets to stand up research programs spanning basic virology and immunology ...
Source: Videocast - All Events - April 13, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Joseph J. Kinyoun Memorial Lecture - Antibodies Against Ebola and Lassa: A Global Collaboration
Joseph J. Kinyoun Memorial Lecture 2017
Dr. Erica Ollmann Saphire, director of the Viral Hemorrhagic Fever Immunotherapeutic Consortium (VIC), will deliver the 2017 Joseph J. Kinyoun Memorial Lecture.
Her talk, “ Antibodies Against Ebola and Lassa: A Global Collaboration, ” will explore the features of antibodies that protect against these deadly viruses and the ongoing need for scientists to collaborate in this research to establish a complete knowledge base. During the past three years, VIC researchers from dozens of labs on five continents have studied these protective antibodies. The VIC aims to fill critical knowl...
Source: Videocast - All Events - November 27, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinical Trial Designs for Emerging Infectious Diseases (Day 2)
The Ebola Virus Disease (EVD) epidemic has highlighted the importance of being able to rapidly evaluate investigational products during a public health emergency, including in resource limited settings. It is generally agreed that access to early investigational interventions that have not yet been well characterized should be provided in a setting that allows for the reliable assessment of benefits and harms. Ascertaining the safety and efficacy of an investigational product is an important step that is necessary to protect and promote the public health now and in the future. A critical aspect of the response effort is t...
Source: Videocast - All Events - November 5, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Clinical Trial Designs for Emerging Infectious Diseases - Breakout Session (Day 2)
The Ebola Virus Disease (EVD) epidemic has highlighted the importance of being able to rapidly evaluate investigational products during a public health emergency, including in resource limited settings. It is generally agreed that access to early investigational interventions that have not yet been well characterized should be provided in a setting that allows for the reliable assessment of benefits and harms. Ascertaining the safety and efficacy of an investigational product is an important step that is necessary to protect and promote the public health now and in the future. A critical aspect of the response effort is t...
Source: Videocast - All Events - November 5, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Clinical Trial Designs for Emerging Infectious Diseases (Day 1)
The Ebola Virus Disease (EVD) epidemic has highlighted the importance of being able to rapidly evaluate investigational products during a public health emergency, including in resource limited settings. It is generally agreed that access to early investigational interventions that have not yet been well characterized should be provided in a setting that allows for the reliable assessment of benefits and harms. Ascertaining the safety and efficacy of an investigational product is an important step that is necessary to protect and promote the public health now and in the future. A critical aspect of the response effort is t...
Source: Videocast - All Events - November 4, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
NIH Research Festival: A Celebration of Intramural Science Plenary Session II: Responding to Public Health Emergencies
This plenary session will focus on the many ways that the NIH Intramural Research Program (IRP) has served a crucial role in various public health emergencies. From assessing radiation dangers after the Japanese tsunami and nuclear accident, to developing an Ebola vaccine and treating infected individuals, to tracing the origins of recent food-borne disease outbreaks through genomic analysis, the NIH IRP continues to be among the "first responders" to protect the nation's and the world's health.For more information go to http://researchfestival.nih.gov/2015/plenary_sessions.shtmlAir date: 9/17/2015 10:15:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - September 15, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Immunology of Protection from Ebola Virus Infection
The goal of this workshop, which is co-sponsored by FDA, NIAID, DOD, CDC, and BARDA, is to discuss important aspects of Ebola virus and vaccine immunology in order to inform future clinical, scientific and regulatory decision-making related to vaccines against Ebola.For more information go to https://respond.niaid.nih.gov/conferences/Ebola/Pages/Immunology%20of%20Protection%20from%20Ebola%20Virus%20Infection.aspxAir date: 12/12/2014 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - December 8, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Ebola Virus Infection
Dr. Bausch, a Filovirus expert with extensive field
experience in previous Ebola and Marburg outbreaks, has been intimately involved in control efforts for the WHO in the current Ebola outbreak in West Africa. Dr. Bausch is the coordinator of their efforts supporting therapeutics, vaccines and clinical research studies of Ebola in the current outbreak.Air date: 9/19/2014 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 18, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
