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A personal mission to get obese patients on GLP-1 agonists [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! “Obesity is not the consequence of bad behaviors it is a disease that finally has effective, safe, lasting treatments. Patients with obesity have been marginalized long enough. We, especially health care providers, have got to start taking down barriers for these patients — not Read more… A personal mission to get obese patients on GLP-1 agonists [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 9, 2022 Category: General Medicine Authors: Tags: Podcast Diabetes Endocrinology Source Type: blogs

Fight Aging! Newsletter, December 5th 2022
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - December 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Calorie Restriction as a Treatment to Slow Parkinson's Disease
Calorie restriction is known to suppress inflammation to some degree, alongside many other benefits to health that result from the reaction of cells and biological systems to a reduced calorie intake. Since chronic inflammation in brain tissue is implicated in the onset and development of neurodegenerative conditions, this makes calorie restriction a topic of interest in this part of the field. With a few exceptions, that interest largely manifests as research aimed at reproducing some of the metabolic alterations of calorie restriction with small molecule drugs, however, rather than more more rigorously testing calorie re...
Source: Fight Aging! - December 2, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

This Simple Exercise Triples Weight Loss
Around one-third of people over 65 are overweight or obese. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - November 30, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs

The Herb That Boosts Weight Loss And Lowers Blood Pressure
Around one-in-three adults in the US are obese. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - November 29, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs

Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Further Discussion of the Poor Evidence For Metformin to Even Mildly Slow Aging`
The problem with metformin as a drug to slow aging is that the evidece to support that use is very poor. In animal studies, the results are very unreliable, and the Interventions Testing Program found no effect in its highly overengineered studies. Further, the existing human data is not supportive, taken as a whole. Even if we did want to cherry pick the better data and be hopeful, the effect size compares unfavorably with that achieved through regular exercise, and further appears to be only achieved in people with the abnormal metabolism associated with obesity and diabetes. All of the work that was done to convince the...
Source: Fight Aging! - November 24, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Gene Pathway Analysis In Action – 3 × 4 DNA Test Review
In the past couple of years, I have taken at least 10 genetic tests, including this latest DNA test from 3×4 Genetics. This may seem excessive, but I have my reasons. I graduated from medical school as a genetic specialist and completed my PhD as a clinical genomics researcher, and although I turned to medical futurism, my original field never ceases to fascinate me. I’m very curious about how these tests advance and hope I might be able to provide insights for patients worldwide about what they can expect to learn from such tests and what those tests can really deliver. Thus, I didn’t hesitate for a second to ...
Source: The Medical Futurist - November 24, 2022 Category: Information Technology Authors: Andrea Koncz Tags: Genomics Personalized Medicine dna testing genetic test Genetic testing review dna test review 3x4 Genetics pathway analysis Source Type: blogs

Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer. The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Common Drugs Linked To Stomach Bloating
The drugs increase the risk of obesity, diabetes, and intestinal infections by altering gut bacteria. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - November 20, 2022 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Stomach bloating Source Type: blogs

Be a shining example for your weight loss patients
How can you be an example of what’s possible for your patients on their weight loss journey? I got this question recently in a doctor’s social media group I like. The answer is simpler than you think. As their doctor, you aspire to perfection in your medical care for them, but you can be an Read more… Be a shining example for your weight loss patients originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 15, 2022 Category: General Medicine Authors: Tags: Conditions Obesity Source Type: blogs

Effects of Gly-Low Supplementation on Long Term Health in Mice
The gly-low combination of common supplements is sold as GLYLO by Juvify Health, another of the supplement-focused spinout companies from the Buck Institute, an organization that should consider starting spinning out companies that are doing something more ambitious to treat aging as a medical condition. The scientifically interesting part of the underlying research is that inhibiting glycation to reduce methylglyoxal based advanced glycation endproducts (AGEs) appears, for reasons yet to be determined, to reduce appetite in mice. This leads to modest calorie restriction, and calorie restriction is well known to produce a ...
Source: Fight Aging! - November 14, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Rapid Diagnosis: Vomiting Blood
The dispatcher reports that the patient is vomiting blood. Hemataemesis if you want to be technical about it. It could be a whole bunch of things right? … Well yes it could. Before you e-mail me to say that you can’t believe I missed Bolivian Hemorrhagic Fever, here’s one web site that lists 113 possibilities. But if you want to play the numbers, it’s going to be one of four things. And if you want to play “stump your partner” you can narrow it down quite a bit based on your patients age and disposition. There are four things that tend to cause a person to vomit blood. Before you click on the little ...
Source: The EMT Spot - November 14, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs

What Time Should You Check Your Blood Pressure?
ConclusionBest Time To Check Blood Pressure Many experts recommend that you check your blood pressure at least twice a day. This could be once in the morning and again at night. Doctors normally suggest checking your blood pressure at least twice a year. But there are other times when it may be worth checking. If you have anxiety or experience high blood pressure episodes lasting more than two hours. If you have shortness of breath, chest pain, rapid heart rate, sweating, lightheadedness, nausea or vomiting, consult your doctor immediately. Choosing A Time That Works For You You can check your blood pre...
Source: The EMT Spot - November 11, 2022 Category: Emergency Medicine Authors: Michael Kutryk Tags: Guides Blood Pressure Source Type: blogs

Isolated Systolic Hypertension: Causes, Treatments, and More
ConclusionWhat Is Isolated Systolic Hypertension? If you have isolated systolic hypertension, your systolic blood pressure (the top number in the BP reading) is high, but your diastolic blood pressure (the bottom number) is normal. Stages of Isolated Systolic Hypertension Normal BP: 120/80 mmHg Elevated BP: 120-129/80 mmHg Hypertension Stage 1: 130-39/80-89 mmHg Hypertension Stage 2:  139 mmHg />89 mmHg Isolated systolic hypertension is more common in older adults. This condition is also more prevalent in men than women. Untreated isolated systolic hypertension can lead to serious health prob...
Source: The EMT Spot - November 11, 2022 Category: Emergency Medicine Authors: Michael Kutryk Tags: Guides Blood Pressure Source Type: blogs