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Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution. « Back to Top Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fruit and sugar: Debunking the myths
On many occasions, patients have asked me whether it’s OK to eat fruit. They’re worried about whether they should be eating foods high in sugar. Is fruit in that category? No, it is not. Does anyone really believe that fruit is what’s causing the paired epidemics of diabetes and obesity? This scourge is not being Read more… Fruit and sugar: Debunking the myths originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 13, 2023 Category: General Medicine Authors: Tags: Conditions Nutrition Source Type: blogs

The High Cost of Type 2 Diabetes as a Lifestyle Condition
Type 2 diabetes is near entirely a lifestyle condition, and can be reversed even in later stages via suitably aggressive dietary and weight loss interventions. Obesity in early adult life is sufficient to cause type 2 diabetes via some combination of mechanisms involving excess fat in the pancreas and increased stress put upon insulin-generating beta cells resident in the pancreas, leading to greater cellular senescence and altered cell behavior. Excess visceral fat is in general harmful to the body via its metabolic activity. There are a range of ways beyond an increased burden of senescent cells by which it can produce c...
Source: Fight Aging! - October 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

COVID vaccines and weight loss medications: a tale of 2 needles
I am perplexed by two different needles which, when viewed together, illustrate the irrational themes which dominate our shared humanity. They inform me that, despite being a doctor for more than twenty years, I honestly feel dumber each day about human behavior. If, unlike me, you have somehow figured out more along the way, good Read more… COVID vaccines and weight loss medications: a tale of 2 needles originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 12, 2023 Category: General Medicine Authors: Tags: Conditions COVID Obesity Source Type: blogs

The Popular Weight Loss Drug That Also Fight Cancer
A popular drug that treats obesity may also help to destroy cancer cells. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - October 12, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Cancer Source Type: blogs

T Cell Exhaustion and the Role of Infections in Alzheimer's Disease
In this study we examined immune system alterations early in the progression to Alzheimer's disease (AD). We observed multiple changes across the peripheral innate and adaptive immune systems associated with amyloid and cognitive status within our aging cohort. In the innate immune system, we observed increased plasmacytoid and myeloid dendritic cells in amyloid positive participants, but these changes were particularly pronounced in those with mild cognitive impairment. We also observed a decrease in total natural killer cells with amyloid positivity. When the adaptive immune system was examined, we observed increases in ...
Source: Fight Aging! - October 10, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The Mindful Body argues against mindlessly accepting age-related decline in cognition and health as inevitable
In 1979, Harvard researcher Ellen Langer invited elderly men to spend a week at a retreat designed to remind them of their younger days, surrounded by the art, music, food, games, décor, and more from the late 1950s. Afterward, the men were tested and found to have made significant gains in hearing, memory, dexterity, posture, and general well-being. It was as if being in a place signaling their younger days made them physiologically “younger.” Maybe you, too, have had an experience where your mind seemed to affect your health. It turns out there’s a reason for that, according to Langer, author of the new book The M...
Source: SharpBrains - October 9, 2023 Category: Neuroscience Authors: Greater Good Science Center Tags: Brain/ Mental Health Education & Lifelong Learning anti-anxiety medication anti-depressants book cognition cognitive change cognitive-abilities Ellen Langer mind mindfulness-meditation mindlessly physiology placebo studies Th Source Type: blogs

Out of Control Health Costs or a Broken Society
Flawed Accounting for the US Health Spending Problem By Jeff Goldsmith Source: OECD, Our World in Data Late last year, I saw this chart which made my heart sink. It compared US life expectancy to its health spending since 1970 vs. other countries. As you can see,  the US began peeling off from the rest of the civilized world in the mid-1980’s. Then US life expectancy began falling around 2015, even as health spending continued to rise. We lost two more full years of life expectancy to COVID. By  the end of 2022, the US had given up 26 years-worth of progress in life expectancy gains. Adding four more ...
Source: The Health Care Blog - October 9, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy COVID Drug Overdoses gun violence Hospitals Jeff Goldsmith Maternal mortality Mental Health Obesity Poverty Regional Economy Society Source Type: blogs

Out of Control Health Costs or a Broken Society
Flawed Accounting for the US Health Spending Problem By Jeff Goldsmith Source: OECD, Our World in Data Late last year, I saw this chart which made my heart sink. It compared US life expectancy to its health spending since 1970 vs. other countries. As you can see,  the US began peeling off from the rest of the civilized world in the mid-1980’s. Then US life expectancy began falling around 2015, even as health spending continued to rise. We lost two more full years of life expectancy to COVID. By  the end of 2022, the US had given up 26 years-worth of progress in life expecta...
Source: The Health Care Blog - October 9, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy COVID Drug Overdoses gun violence Hospitals Jeff Goldsmith Maternal mortality Mental Health Obesity Poverty Regional Economy Society Source Type: blogs

Fight Aging! Newsletter, October 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Bonus Features – October 8, 2023 – 67% of Women are Having Issues with Getting a Clear Diagnosis – of which 25% are Still Waiting for Diagnosis or Gave up Entirely, Health Gorilla has 17 Healthcare Organizations Commit to Joining their QHIN, and More!
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job. News This year’s Customer Forum and Innovation Summit from Avel eCare will double as a celebration of their 30th anniversary! PEP Health’s AI-powered Patient Experience Platform releases its first report offering qua...
Source: EMR and HIPAA - October 8, 2023 Category: Information Technology Authors: Grayson Miller Tags: Healthcare IT 9amHealth Accelecom Amazon Web Services Artisight athenahealth Atropos Health Avel eCare AVIA Banner Health BJC Healthcare Boston Children's Hospital Children's Mercy Kansas City Cottage Health DrFirst Emma Smit Source Type: blogs

Narcissism: 9 Insightful Psychology Studies
How to spot a narcissist, how to tell it from high self-esteem, how the trait is related to eating disorders and how to deal with a narcissist. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - October 5, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Narcissism Source Type: blogs

An Estrogen-Related Receptor Agonist Exercise Mimetic Performs Well in Mice
Researchers here demonstrate in mice an effective approach to mimicking some of the adaptive responses to exercise, and sustaining those responses over time. Exercise mimetics have undergone a sedate pace of development in comparison to the larger body of work on calorie restriction mimetics, intended to mimick some of the sweeping changes to metabolism that occur at low nutrient levels, and the field isn't yet as well established. Still, some interesting lines of work have emerged, such as the program noted here. The new drug, known as SLU-PP-332, doesn't affect appetite or food intake. Nor does it cause mice to ...
Source: Fight Aging! - October 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Unraveling the complex enigma of obesity [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! We sit down with Franchell Hamilton, a bariatric surgeon, to explore the intriguing link between genetics, brain function, and obesity. She shares her insights into why many patients don’t feel full even after eating, even post-bariatric surgery. We delve into the role of dopamine Read more… Unraveling the complex enigma of obesity [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 30, 2023 Category: General Medicine Authors: Tags: Podcast Obesity Source Type: blogs

5 things to know about weight from a bariatric surgeon
You’ve probably had friends and family corner you to look at a rash or talk about medications. With social media exploding about Ozempic, these questions and even curbsides from physicians have boomed. We all want to know more about weight. As a bariatric surgeon, here are five things every physician should know about weight: How Read more… 5 things to know about weight from a bariatric surgeon originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 26, 2023 Category: General Medicine Authors: Tags: Conditions Obesity Source Type: blogs