Patient Advocates Argue Exercising Bayh-Dole " March-In " Rights Reasonable to Ensure Ongoing Supply of an Insulin Novo Nordisk Intends to Discontinue
Back in 2016 (when President Obama was still in office), the trade group known as the Pharmaceutical Research and Manufacturers of America (better known by the acronym PhRMA) claimed in an organization-published white paper (seehttps://web.archive.org/web/20161022175500/https://phrma.org/sites/default/files/pdf/bayh-dole-act-white-paper-summary.pdf for an archived copy of that paper from PhRMA; note that it has since been removed from PhRMA ' s website, hence I found a copy on the Internet Archive) that championed the Bayh-Dole Act of 1980. Understand that what PhRMA really wants to prevent a particular provision...
Source: Scott's Web Log - February 11, 2024 Category: Endocrinology Tags: march-in rights 2024 Alliance to Protect Insulin Choice APIC Bayh-Dole insulin detemir Levemir Novo Nordisk Source Type: blogs

Fight Aging! Newsletter, February 12th 2024
In conclusion, frailty is a dynamic process, and improved frailty and remaining robust are significantly associated with lower risk of all-cause mortality and cardiovascular death in older people. « Back to Top Greater Individual Wealth Correlates with Longer Life Expectancy https://www.fightaging.org/archives/2024/02/greater-individual-wealth-correlates-with-longer-life-expectancy/ Individual wealth correlates with life expectancy, with an effect size that is in the same ballpark as those related to lifestyle choices involving exercise, diet, and consequences thereof. It remains unclear...
Source: Fight Aging! - February 11, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Who to Blame for Health Costs: The Poisoned Chalice of “ Moral Hazard ”
By JEFF GOLDSMITH How the Search for Perfect Markets has Damaged Health Policy Sometimes ideas in healthcare are so powerful that they haunt us for generations even though their link to the real world we all live in is tenuous. The idea of “moral hazard” is one of these ideas.   In 1963, future Nobel Laureate economist Kenneth Arrow wrote an influential essay about the applicability of market principles to medicine entitled “Uncertainty and the Welfare Economics of Medical Care”.     One problem Arrow mentioned in this essay was “moral hazard”- the enhancement of demand for something people us...
Source: The Health Care Blog - February 8, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Health Care Costs Jeff Goldsmith Kenneth Arrow Medicare Moral Hazard Source Type: blogs

Intermittent Fasting Produces Indeterminate Effects on BDNF Levels in Humans
The circulating level of brain-derived neurotrophic factor (BDNF) is a widely-researched target for intervention. Increased BDNF seems to be wholly beneficial, particularly in its effects on neurogenesis, the production of new neurons and their integration into existing neural networks in the brain. Neurogenesis declines over the course of adult life, and is necessary to the function of memory and maintenance of brain tissue. Circulating BDNF, where levels also decline with age, might be the most convenient of the available mechanisms with which to affect neurogenesis. It can be increased by exercise, butyrate supplementat...
Source: Fight Aging! - February 7, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Hope, healing, and challenges in eating disorder recovery [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join Jillian Rigert, an oral medicine specialist and radiation oncology research fellow. In this episode, we delve into the world of eating disorders, drawing from Jillian’s unique perspective as both a patient and a health care professional. We explore topics such as maintaining hope Read more… Hope, healing, and challenges in eating disorder recovery [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 6, 2024 Category: General Medicine Authors: Tags: Podcast Obesity Source Type: blogs

The Business Case for a Biosimilar Company to Bring a Copy of Levemir to Market
My readers may recall that in November 2023, I blogged that Novo Nordisk announced it plans to retire (stop making) its first " Lantus killer " known as Levemir (insulin detemir injection) in the U.S. in 2024 (catch my post at https://blog.sstrumello.com/2023/11/novo-nordisk-to-discontinue-levemir-in.html for more). At the time I learned of the announcement, I was on vacation in Amsterdam, so I just made a note of the development and blogged about it a few weeks later upon my return.Like other patients my age, I have endured the company ' s previous insulin " retirements " . Novo Nordisk ' s time-frame for withdr...
Source: Scott's Web Log - January 25, 2024 Category: Endocrinology Tags: 2024 Biosimilar Levemir Novo Nordisk PBM Source Type: blogs

A man in his 30s with chest pain. How was he managed? What if they had used the Queen of Hearts?
Written by Pendell MeyersA man in his late 30s with history of hypertension, tobacco use, and obesity presented to the Emergency Department for acute chest pain which started approximately 3 hours prior to arrival, in the setting of a very stressful situation. The pain radiated down both arms, 10/10 in severity. He stated it did not feel like his prior episodes of reflux. Vitals were within normal limits except some hypertension. Triage ECG:And here she explains her assessment:The ECG was read as simply " No ST elevation. " Which is true.The initial high sensitivity troponin I returned at around 3300 ng/L. No repeat E...
Source: Dr. Smith's ECG Blog - January 20, 2024 Category: Cardiology Authors: Pendell Source Type: blogs

Six favorite books of 2023 to help harness the stress response and boost resilience, curiosity and wonder
It’s hard to address important issues in our lives or in society if we are stressed, depleted, and isolated. Perhaps that’s why many of 2023’s favorite books offer approaches for real self-care. They focus on how to manage stress, find more happiness in life, seek wonder and inspiration, appreciate art, understand our personal strengths, or change our mindset in healthy ways. In each of these books, the authors aspire to help us find greater health and happiness as we cope with life in the present, while working toward a healthier, more compassionate world for all. Tomorrowmind: Thriving at Work—Now and in an Uncer...
Source: SharpBrains - January 16, 2024 Category: Neuroscience Authors: Greater Good Science Center Tags: Brain/ Mental Health Education & Lifelong Learning art Books happiness healthy manage-stress mindful mindset resilience Stress Response workplace Source Type: blogs

The body positivity movement: Has it become toxic?
Delving into the topic of the body positivity movement requires the unpacking of many other issues facing society today. This topic cannot be looked at in a vacuum. We live in an era where diversity and inclusion have become core values in many aspects of American life, and body positivity is a subset of that. Read more… The body positivity movement: Has it become toxic? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 15, 2024 Category: General Medicine Authors: Tags: Conditions Obesity Source Type: blogs

knownwell Raises $20M Series A From A16Z to Scale the First Patient-Centered Healthcare Home For Those With Overweight and Obesity
Building on This Mission, the Company is Launching an Adolescent Metabolic Health Program to Combat Rising Child Obesity Rates knownwell, an in-person and virtual, weight-inclusive primary care and metabolic health company, today announced that it has raised a $20 million Series A funding round led by a16z with participation from existing investors including Flare Capital Partners. This brings knownwell’s total funding to $24.5 million and highlights a growing demand for weight-inclusive care companies focusing on whole-person treatment approaches to obesity beyond just short-term approaches like GLP-1 utilization organi...
Source: EMR and HIPAA - January 15, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT a16z Brooke Boyarsky Pratt Dr. Angela Fitch Flare Capital Partners Health IT Funding Health IT Fundings Health IT Investment knownwell Vineeta Agarwala Source Type: blogs

The “ Ozempic body ” phenomenon
In a serendipitous encounter, I crossed paths with an old schoolmate of mine whimsically dubbed Fluffy Carol during our shared medical residency. Famous for her arresting charm and infectious smile, she was, in many ways, the life of the party if we ever had one. Despite her endearing qualities, one mischievous fellow in our group Read more… The “Ozempic body” phenomenon originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 15, 2024 Category: General Medicine Authors: Tags: Conditions Obesity Source Type: blogs

CoachCare Acquires Verustat
Fourth Acquisition Bolsters Remote Patient Monitoring Company’s Presence in Primary Care and Cardiology CoachCare, a leading remote patient monitoring (RPM) and virtual health company, has acquired Nashville, Tennessee-based RPM company Verustat, for an undisclosed amount. The acquisition represents CoachCare’s fourth acquisition in 12 months. Founded in 2020, Verustat brings a valuable roster of RPM clients focused on primary care and cardiology. This adds to CoachCare’s leadership position by supporting the most prevalent chronic conditions, such as hypertension, obesity, and diabetes. One of the fastest growing di...
Source: EMR and HIPAA - January 12, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT CoachCare Health IT Acquisitions Healthcare M&A Hughey Business Law pH Partners Verustat Wes Haydon Whitman Breed Abbott & Morgan Source Type: blogs

Inequality, Stress, and Obesity: Socioeconomic Disparities in the Short- and Long-Term Effects of the COVID-19 Pandemic
Maria Langlois (Southern Methodist University), Pierre Chandon (INSEAD), Inequality, Stress, and Obesity: Socioeconomic Disparities in the Short- and Long-Term Effects of the COVID-19 Pandemic, J. of the Ass ’n for Consumer Rsch. (2023): In a longitudinal study of a large sample... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - January 9, 2024 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs

Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction. Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group. Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs