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Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT. Age-Related Dysfunction of Water Homeostasis https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/ Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechan...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Fruit That Helps Weight Loss And Prevents Diabetes
A compound found only in this food can help stop type 2 diabetes and fight obesity. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - June 16, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Diabetes Source Type: blogs

Taurine Supplementation Slows Aging, Extends Life in Mice
Taurine levels drop with age, and correlate with health in aged humans. Researchers here show evidence for taurine supplementation to improve health and extend life span in mice. While it isn't mentioned in this paper, if one takes a look around the literature on this topic, taurine may act on the pace of aging by increasing levels of the antioxidant enzyme glutathione, and has been shown to diminish oxidative stress. You may recall that supplementation with glutathione precursors has been shown to improve health in both old mice and old humans. Glutathione itself is harder to deliver directly, hence the more indirect stra...
Source: Fight Aging! - June 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fat Infiltration of Muscle Correlates with Age-Related Cognitive Decline
Researchers here show that great fat infiltration of skeletal muscle tissue correlates well with the progressive loss of cognitive function that occurs with advancing age. It is well demonstrated that greater visceral fat mass accelerates the declines of aging, but researchers here suggest that fat deposition in skeletal muscle correlated with cognitive decline independently of the degree to which study participants were overweight. The underlying reasons as to why two people of the same overall adiposity may have different degrees of intramuscular fat deposition are not well understood, but this manifestation of aging cor...
Source: Fight Aging! - June 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

AGEs Produce Harmful Effects via Interaction with RAGE
Advanced glycation end-products (AGEs) are a threefold problem. Firstly, a few species of persistent AGEs can form lasting cross-links between structural molecules of the extracellular matrix that alter its tensile properties, such as a loss of elasticity. Human biochemistry is ill-suited to the task of removing these cross-links, particularly those based on glucosepane. Secondly, AGEs can bind to proteins and modify their function, acting as a form of damage that cells must clear. Thirdly, transient AGEs interact with the receptor for AGEs, RAGE, to produce chronic inflammation and cellular dysfunction. This is characteri...
Source: Fight Aging! - June 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Unveiling the game-changing diabetic drugs: Revolutionizing weight loss and diabetes management
The drug representative had a smug look; she knew she had a winner. She didn’t need to sell anything—the American public had already bought the story. There are very few drugs in history where patients are excited about the conversation and want to take a new medication. I am talking about the new class of Read more… Unveiling the game-changing diabetic drugs: Revolutionizing weight loss and diabetes management originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 13, 2023 Category: General Medicine Authors: Dinesh Arab, MD Tags: Meds Obesity Source Type: blogs

Thymus Atrophy in Middle Age
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT. Link: https://doi.org/10.21203/rs.3.rs-2499784/v1 (Source: Fight Aging!)
Source: Fight Aging! - June 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Breaking free from BMI ’ s limitations for fair and effective care
The 2023 Clinical Practice Guideline for Evaluation and Treatment of Children and Adolescents with Obesity heralds a new era of evidence-based anti-obesity treatments for children, a cause I wholeheartedly support. However, amidst these advancements, I harbor concerns about the ongoing reliance on the body mass index (BMI) as a screening and diagnostic tool. Originally designed Read more… Breaking free from BMI’s limitations for fair and effective care originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 11, 2023 Category: General Medicine Authors: Natasha Agbai, MD Tags: Conditions Pediatrics Source Type: blogs

Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The First Amendment Protects Against Bad ‐Faith Prosecutions
Thomas A. BerryIn 2020, Netflix began streaming the French filmCuties. The film follows an 11 ‐year‐old Senegalese immigrant, Amy, torn between her family’s conservative culture and a more progressive French society. In the film, Amy is shown joining a pre‐teen dance group (the “Cuties”), whose sexualized routines are heavily influenced by social media. The film’s me ssage is critical of the influence of social media on young girls, but the film itself attracted significant controversy for its scenes depicting the dance group’s provocative performances.There is room for reasonable debate as to wh...
Source: Cato-at-liberty - June 8, 2023 Category: American Health Authors: Thomas A. Berry Source Type: blogs

The Gut Microbiome Differs in Characteristic Ways in Patients with Precancerous Colon Polyps
The gut microbiome changes with age, the relative abundance of microbial populations shifting in ways that appear connected to chronic inflammation and dysfunction of the intestinal epithelium and intestinal barrier function. Cancer of the colon is an important cause of human mortality, and there is some hope that finding ways to prevent or reverse gut microbiome aging, such as via fecal microbiota transplant from young individuals, will go some way to minimizing colon cancer incidence. Colorectal cancer is the second leading cause of cancer-related death in the U.S., and rates of colorectal cancer are rising amon...
Source: Fight Aging! - June 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A Hand Up, Not a Hand-Out
BY KIM BELLARD As many of you did, I followed the recent debt ceiling saga closely, and am relieved that we now have a compromise, of sorts. The House Republicans demanded a lot of things, most of which they did not get, but one area where they did prevail was in toughening work requirements for food (SNAP) and income (TANF). They somehow believe that there are uncounted numbers of “able-bodied” people sitting around on their couches collecting government benefits, a myth that goes back to Ronald Reagan’s welfare queen stereotype, and have long advocated work requirements as the remedy. Ironic...
Source: The Health Care Blog - June 6, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Guaranteed Income Programs Kim Bellard SNAP Source Type: blogs

HealthSnap Raises $9 Million Series A for Continued Growth of Remote Patient Monitoring and Chronic Care Management Platform
The Investment, Led by Asclepius Growth Capital and Leading Health System Partners, will Enable Care Teams to Empower Patients with a More Personalized Remote-Care Experience HealthSnap, a Miami-based virtual care management platform for chronic disease management, today announced a new round of financing totaling $9 million. The round was led by Asclepius Growth Capital, an SPV founded by David Jahns, a managing director of Galen Partners, and Steve Cashman, CEO at Caption Health and former CCO at InTouch Health, as well as new strategic investments from current business partners UnityPoint Health and Tampa General H...
Source: EMR and HIPAA - June 2, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Asclepius Growth Capital Caption Health CCM Chronic Disease Management David Jahns Florida Funders Galen Partners Health IT Funding Health IT Fundings Health IT Investment HealthSnap InTouch Health Source Type: blogs

Masked Hypertension: Your Silent Health Threat
Conclusion Masked hypertension is a silent threat that occurs when normal blood pressure readings at the doctor’s office conceal high readings at home or elsewhere. Although the precise cause remains uncertain, factors like smoking, excessive alcohol, and work-related stress appear to play a role. Despite the symptomless nature of this condition, regular monitoring of blood pressure can help detect and manage it effectively, preventing serious complications. Regular lifestyle modifications and prescribed medications can help keep this masked menace at bay. References Cuspidi, C., et al. (2023). Masked hy...
Source: The EMT Spot - May 30, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

Clinical Examination of Cardiovascular System For Medical Students
Discussion on blood pressure is not included here as a separate topic is dedicated to it. Though the most commonly examined pulse is the radial, to check some of the characteristics, a more proximal pulse like the brachial or carotid needs to be examined. Following parameters of the pulse are routinely documented: 1. The rate: Normal rate in adult is 60-100 per minute. It is higher in children. Younger the child, higher the pulse rate. Rhythm: Regular and irregular rhythms are possible. Mild variation with respiration is called respiratory sinus arrhythmia, with higher rate in inspiration. Respiratory sinus arrhythmia may...
Source: Cardiophile MD - May 30, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs