Microsoft CEO Sees Generative AI as Transformative as Relational Databases
At Epic’s 2023 User Group Meeting (#epicugm), Microsoft CEO Satya Nadella and Sumit Rana, Senior Vice President at Epic sat down for a one-on-one conversation about generative AI. Their conversation was fascinating on two levels. First, it was surprising that they did not speak to the deeper partnership between the two companies that was announced in the hours ahead of their time on stage. Second, was the blink-and-you-missed-it difference between how the two men view generative AI.
Deeper Partnership Between Epic and Microsoft
Early on Tuesday morning an announcement was made about the expanded collaboration between...
Source: EMR and HIPAA - August 25, 2023 Category: Information Technology Authors: Colin Hung Tags: AI/Machine Learning C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Azure ChatGPT Epic Epic UGM Generative AI Healthcare AI Judy Faulkner Microsoft Nuance DAX Satya Nadella Sumit Rana Source Type: blogs
The Intellectual Property Journey Of Patients ’ Digital Health Data
If you have used or are using a digital health device or service to gain insights about your own health, you have a digital health data trail. Whether it’s your smartwatch or that genetic sequencing you took to know about your risks for certain ailments, your personal data has been logged digitally. The latter is often used by companies providing digital health services to fine-tune their products and generate intellectual property (IP).
As users of such services, it becomes ever important to understand (or at least try to) where that data ends up and consider who should own the resulting IP. We decided to follow the ...
Source: The Medical Futurist - August 22, 2023 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF health data IP of health data Source Type: blogs
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
75 year old dialysis patient with nausea, vomiting and lightheadedness
Written by Jesse McLaren A 75 year-old patient with diabetes and end stage renal
disease was sent to the ED after dialysis for three days of nausea, vomiting,
loose stool, lightheadedness and fatigue. RR18 sat 99% HR 90 BP 90/60, afebrile. Below is the 15 lead ECG. What do you think? There ’s normal sinus rhythm, normal conduction, normal axis,
normal R wave progression and normal voltages. There’s subtle inferior ST
elevation with straightening of the ST segment, reciprocal ST depression and T
wave inversion in aVL, and ST depression in V2. This is diagnostic of
infero-posterior OMI, but it is falsely n...
Source: Dr. Smith's ECG Blog - August 19, 2023 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Associations Between the Lipidome and Epigenetic Aging
The body contains hundreds of different types of lipid molecules, participating in cellular metabolism in ways that are just as complex and relevant to health as the activities of other biomolecules. In the context of aging, this broad range of lipids are perhaps understudied in comparison to levels and roles of proteins and patterns of gene expression. The situation is much the same, however: researchers can readily and cost-effectively amass a vast amount of data, but the analysis of this data lags far behind the accumulation of ever more and ever larger omics databases. It is ever unclear as to whether any particular as...
Source: Fight Aging! - August 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Universal Epigenetic Aging Clock for All Mammalian Species
Epigenetic modifications to the nuclear genome, such as the addition of methyl groups to CpG sites, known as DNA methylation, adjust the structure of double-stranded DNA. That structure determines which gene sequences are accessible to transcription machinery, the first step in producing proteins. Thus epigenetics drives gene expression, and gene expression drives the behavior of cells. It is a feedback loop between environment, cell behavior, and epigenetics. The pattern of epigenetic modifications changes constantly in response to circumstances, but some changes are characteristic of aging. When discovered, this led to t...
Source: Fight Aging! - August 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Top 6 Companies Using AI In Drug Discovery And Development
What if coming up with a new drug could be measured in days rather than years? What if new medication would cost thousands instead of billions of dollars? Just look at how an AI pharma start-up developed a potential new drug in 46 days! Artificial intelligence technologies promise to speed up the process of drug discovery and development and make it more cost-effective. As the market is flourishing, and it takes time and effort to separate the wheat from the chaff, we collected the most promising AI pharma companies out there.
Drug design is a key area AI is revolutionizing. In one of our latest database projects, we de...
Source: The Medical Futurist - August 17, 2023 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Future of Pharma Genomics research clinical trials AI drug development medication drug discovery drug research cure Source Type: blogs
Predicting Mildly Age-Slowing Drugs will be a Focus of Future Research
It is clear that new ways of analyzing large amounts of data via machine learning will be used extensively in the near future in the field of aging research, employed to speed up the process of finding new drug targets and small molecules that might alter metabolism to slightly slow aging. This will no doubt be a sizable component of the longevity industry, if we judge the near future by the present distribution of companies and efforts. I can't say that I think that is likely to produce sizable benefits in aging humans, however, when compared to the rational design of therapies to specifically repair underlying causes of ...
Source: Fight Aging! - August 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
[Browsing] New comments
Any comments on this blog are moderated by me. If they are a question related to the subject of the post, I will answer it (not always very quickly, I have to confess).But most are not related at all. For example:Very complementary about my writing style, but included a link to private tutoring service. Actually there were three at least like this;Opportunities to buy medications - separate offers of NSAIDs, pain medications, benzodiazepines, opioids, barbiturates...;Links to a homoeopathy clinic (as all these comments are, on posts not related to the subject of the comment);Recommendation...
Source: Browsing - August 13, 2023 Category: Databases & Libraries Source Type: blogs
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
« Back to Top
Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't ...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Familial Longevity is Accompanied by Increased Healthspan
In this study we showed that members of long-lived families have a delayed onset of disease, multimorbidity, and medication use as compared to their partners, thereby extending their healthspan with up to a decade. These members also postponed multimorbidity since those who were already diagnosed with an age-related disease had a 54% lower risk of having a second age-related disease compared to their partners.
An increasing number of long-lived ancestors, as measured with the Longevity Relatives Count (LRC) score, not only associates with a lower mortality at any moment in life it also associates, in a similar way,...
Source: Fight Aging! - August 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Blood Protein Signature of Increased Dementia Risk
The search for ways to determine whether someone is in the very early stages of developing dementia overlaps with the development of means to determine biological age. The first step in both cases is to gather a sizable database of omics data, usually from blood samples. Once that data is in hand, why not try to achieve both goals? Alzheimer's disease and other neurodegenerative conditions may exhibit years to decades of slow development prior to evident symptoms, and those underlying processes will show up given the right measurements. The research noted here is one example of the exploration of biomarkers that is present...
Source: Fight Aging! - August 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Unicorn K Health Raises $59 Million in Down Round
The Startup, which was Valued at $1.4 Billion in 2021, has Developed a Platform that uses AI to Combine Professional Medical Knowledge with Patient Clinical Data, Providing Doctors and Users with Information about the Diagnoses and Treatments of Others with Similar Symptoms and Conditions
Israeli startup K Health, which develops a data-driven digital primary care platform, has raised $59 million from the company’s investors and the largest hospital in California, Cedars Sinai. In a conversation with Calcalist CEO and Co-Founder, Allon Bloch refused to comment on the company’s valuation in its latest funding round, ...
Source: EMR and HIPAA - August 7, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT 4W Adam Singolda Allon Bloch BoxGroup Calcalist Cedars-Sinai Dr. Dan Zelter Dr. John Ebbert Gal Gadot Health IT Funding Health IT Fundings Health IT Investment Israel Roth Israeli HMO Maccabi H Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
« Back to Top
Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rutin Suppresses the SASP of Senescent Cells
Senescent cells accumulate with age and cause harm via a sustained, energetic production of signal molecules, the senescence-associated secretory phenotype (SASP), that disrupts tissue structure and function. In addition to the search for senolytic drugs that can selectively destroy senescent cells by pushing them into programmed cell death, researchers are also looking for senomorphic drugs that can suppress some or most of the SASP by interfering in its regulatory mechanisms. This seems to me a poor alternative to clearance of senescent cells, as a senomorphic drug must be taken continually, but nonetheless a great many ...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
