A Peek At QuantumSI's Protein Sequencer
A number of academic labs and startups have been trying to build new ways of parallel sequencing of large numbers of peptides using schemes that have significant resemblance in their logic to the highly parallel DNA sequencing schemes often highlighted in this space; QuantumSI is the first (and so far only) such company to actually commercialize in this space. Resemblances to NGS but not identity - for a few important reasons.The biggest such challenge is the lack of anything resembling Watson-Crick basepairing in proteins. Sequencing chemistries almost invariably rely on basepairing, with the notable exceptions of Maxa...
Source: Omics! Omics! - April 30, 2024 Category: Bioinformatics Authors: Keith Robison Source Type: blogs
11 Ways Conscious Growth Club Will Expand Your Experiential Range
Conscious Growth Club is our primo online self-development club. It’s been running for 7 years now, so we’ve had plenty of time to evolve and improve it.
The new Year 8 version of CGC is especially rich, abundant, and divergent – so different and unique compared to anything I’ve seen elsewhere in the self-development world.
Instead of focusing primarily on content or coaching, in CGC we prioritize crafting and guiding you through unique growth experiences. You’ll learn more through direct experience than you will by just reading and watching videos. CGC includes a strong content library too,...
Source: Steve Pavlina's Personal Development Blog - April 28, 2024 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Abundance Creating Reality Emotions Lifestyle Productivity Relationships Values Source Type: blogs
Fight Aging! Newsletter, April 29th 2024
In conclusion, we assigned stemness scores to human samples and show evidence of a pan-tissue loss of stemness during human aging, which adds weight to the idea that stem cell deterioration may contribute to human aging.
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The Role of Immune Aging in Neurodegenerative Conditions
https://www.fightaging.org/archives/2024/04/the-role-of-immune-aging-in-neurodegenerative-conditions/
The research community has come to see chronic inflammation and other age-related immune system dysfunctions as an important aspect of neurodegenerative conditions. Inflammation in the short term is n...
Source: Fight Aging! - April 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Rodent Aging Interventions Database
You might compare the LEV Foundation's Rodent Aging Interventions Database with the DrugAge database, both emerging from the efforts of researchers who found themselves frequently reviewing the existing literature on age-slowing interventions in animal models. One of the things to bear in mind about the existing literature is that rodent studies that show an apparent modest slowing of aging frequently fail to replicate when later investors take a more rigorous approach, with larger numbers of mice. The history of the NIA Interventions Testing Program is largely a repeated demonstration of this point.
The Rodent Ag...
Source: Fight Aging! - April 25, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What's new in midwifery - 15th April 2024
Selected new (or newish) items of interest. I am trying with this one to use DOIs as the link, please consult your library service, if you have access to one, if you have trouble accessing full text.In the news, Guardian analysis of NHS figures shows black women in England are more likely to have serious birth complications, Some systematic reviews and researchEffectiveness of care bundles in preventing postpartum haemorrhage, a systematic review, Socio-economic disadvantage and utilisation of labour epidural analgesia, a study carried out in Scotland, A systematic review of maternal and neo...
Source: Browsing - April 15, 2024 Category: Databases & Libraries Tags: midwifery Source Type: blogs
Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Medicine is not apolitical: Your vote dictates your ability to practice medicine
It’s Wednesday, March 6th, 2024. The day after Super Tuesday. I am sitting in the library, taking a break from writing a final paper for my health economics class, when I see a Politico article: “San Francisco’s Proposition F passed.” 3,000 miles away from my hometown and my medical school, all I can think about
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Medicine is not apolitical: Your vote dictates your ability to practice medicine originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 11, 2024 Category: General Medicine Authors: Elizabeth Picazo Tags: Policy Public Health & Policy Source Type: blogs
Securing Patient Data: A Practical Guide to Compliance in Open-Source Healthcare CMS
The following is a guest article by Jon Stewart, Co-Founder and President at ZenSource
Historically, the terms “patient data,” “open-source,” and “healthcare CMS” might have seemed incongruous. Open-source has often been perceived as the Wild West. But times have changed, and open-source platforms are now making significant strides, particularly in highly regulated industries. The modern world of the open web combined with a secure cloud, smarter planning, and robust support can enable healthcare organizations to enjoy the benefits of proprietary systems with the cost and flexibility of open-source platforms. S...
Source: EMR and HIPAA - April 11, 2024 Category: Information Technology Authors: Guest Author Tags: Analytics/Big Data Health IT Company Healthcare IT Security and Privacy Cloud Infrastructure CMS Cybersecurity Cybersecurity Training Healthcare CMS Jon Stewart Open Source Healthcare patient data Security Audit ZenSource Source Type: blogs
Intermittent Methionione Restriction may be an Improvement on Continuous Methionine Restriction
Regulatory systems that detect low levels of the essential amino acid methionine are one of the more important triggers for the metabolic response to fasting and calorie restriction. Methionine is not manufactured in mammalian cells, can only be obtained from the diet, but is nonetheless essential for protein synthesis. Thus reducing only methionine levels in the diet can capture a sizable fraction of the benefits of calorie restriction.
While it is possible for a self-experimenter armed with time, a suitable database of methionine content by food type, and considerable willpower to practice significant levels of me...
Source: Fight Aging! - April 10, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
David Lareau, CEO, Medicomp
Medicomp provides a medical database within an EMR and which delivers all the diagnoses and other information directly to the clinician. It represents the note to the physician as a SMART on FHIR app so that they can quickly find the information they need within their workflow. I had a quick catch up with CEO Dave Lareau, and asked him not only what Medicomp does but how all that generative AI has started to change this. He thinks that the output of LLMs and ambient AI will actually make a greater demand for their tools–from a company that’s coming up on its 50th birthday! (Well 46th….)–Matthew Holt...
Source: The Health Care Blog - April 9, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Dave Lareau Generative AI MEDICOMP Source Type: blogs
Lilly's Carelessness in Discontinuing 3 mL vials of Humalog Causes Shortages in 10 mL vials of Humalog + Unbranded Lispro
Last week, the JDRF shared newshttps://x.com/JDRF/status/1770848177354137650 in a series of three Tweets about how Eli Lilly& Company, Inc. was reporting that 10 mL vials of Humalog and the company ' s identical, unbranded (meaning Lilly sells it using the generic drug name rather than brand-name Humalog) version of Humalog known as Lilly Insulin Lispro Injection could be facing temporary lack of availability in selected locations around the country. Lilly tried to reassure everyone that it was only a temporary issue. But while Lilly complains it cannot keep up with demand for Mounjaro/Zepbound, it is having its own su...
Source: Scott's Web Log - April 9, 2024 Category: Endocrinology Tags: Eli Lilly and Company 2024 Humalog lispro vials Source Type: blogs
Cholesterol-Consuming Gut Microbes Lower Heart Disease Risk
Variations in the relative proportions of microbial species making up the gut microbiome apparently contribute to variations in LDL-cholesterol in the bloodstream. Lower LDL-cholesterol sustained over a lifetime produces a slower development of atherosclerotic plaque, and lower risk of consequent cardiovascular disease. While it seems likely there is no one optimal gut microbiome, there are certainly specific improvements that can be achieved for most older individuals. Fortunately, producing lasting changes in the balance of microbial populations making up the gut microbiome is an achievable goal. Fecal microbiota transpl...
Source: Fight Aging! - April 9, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Raised Inflammatory Markers Somewhat Correlate with Incidence of Age-Related Disease
Onset, progression, and resolution of inflammation are all driven by the interaction of many different complex signaling processes. The immune system as a whole is highly complex, an array of many different interacting populations of specialized cells. Nonetheless, there are a few individual circulating signal proteins that, to some degree at least, tend to reflect overall inflammatory status. Not reliably, but enough to produce correlations in patient populations of any reasonable size.
Today's open access paper is a survey of the literature on inflammatory cytokines IL-6, TNF, and IL-1β, pulling reported measures...
Source: Fight Aging! - April 3, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
