IL-10 regulates Th17 response to inhibit hepatobiliary injury caused by Clonorchis sinensis infection in C57BL/6J mice
Clonorchiasis caused by Clonorchis sinensis is a mainly foodborne parasitic disease. It can lead to hepatobiliary duct inflammation, fibrosis, obstructive jaundice, liver cirrhosis, and even cholangiocarcinoma. Interleukin (IL)-10 is an immune-regulatory cytokine which plays an immunosuppressive role during infection. Our previous study found that IL-10 was increased in mice with C. sinensis infection. However, the role and mechanism of IL-10 playing in hepatobiliary injury induced by C. sinensis infection remain unknown. Herein, Il10+/+ mice and Il10+/- C57BL/6J mice were infected with C. sinensis. It was found that IL-10...
Source: Frontiers in cellular and infection microbiology - October 13, 2022 Category: Microbiology Source Type: research
Pangenome-wide analysis of cyclic nucleotide-gated channel (CNGC) gene family in citrus Spp. Revealed their intraspecies diversity and potential roles in abiotic stress tolerance
Cyclic nucleotide-gated channels (CNGC) gene family has been found to be involved in physiological processes including signaling pathways, environmental stresses, plant growth, and development. This gene family of non-selective cation channels is known to regulate the uptake of calcium and is reported in several plant species. The pangenome-wide studies enable researchers to understand the genetic diversity comprehensively; as a comparative analysis of multiple plant species or member of a species at once helps to better understand the evolutionary relationships and diversity present among them. In the current study, pange...
Source: Frontiers in Genetics - October 11, 2022 Category: Genetics & Stem Cells Source Type: research
Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development
Tea plant (Camellia sinensis (L.) O. Kuntze) is an important economic tea crop, but flowering will consume a lot of nutrients of C. sinensis, which will seriously affect the nutritional growth of C. sinensis. How... (Source: BMC Plant Biology)
Source: BMC Plant Biology - October 4, 2022 Category: Biology Authors: Xiaohan Xu, Jing Tao, Anqi Xing, Zichen Wu, Yuqin Xu, Yi Sun, Jiangyuan Zhu, Xiang Dai and Yuhua Wang Tags: Research Source Type: research
Extracellular vesicles of Clonorchis sinensis promote IL-6 and TNF- α secretion via the Toll-like receptor 9-mediated ERK pathway in biliary epithelial cells
Dev Comp Immunol. 2022 Sep 29:104555. doi: 10.1016/j.dci.2022.104555. Online ahead of print.ABSTRACTClonorchis sinensis is closely associated with cholangitis, cholecystitis, biliary fibrosis and cholangiocarcinoma. The present study elucidated the role of extracellular vesicles of C. sinensis (CsEVs) in activating Toll-like receptor 9 (TLR9) and regulating inflammatory responses. The results showed that TLR9 expression was increased in the livers of C. sinensis-infected mice. CsEVs were cup-shaped or saucer-shaped and 80-120 nm in diameter. CsEVs activated TLR9 and promoted IL-6 and TNF-α expression in mouse biliary epit...
Source: Developmental and Comparative Immunology - October 2, 2022 Category: Allergy & Immunology Authors: Yuru Wang Xiaocen Wang Nan Zhang Yanhui Yu Penglin Bao Yeting Ma Haoyang Zhang Xu Zhang Xichen Zhang Pengtao Gong Xin Li Jianhua Li Source Type: research
Genome-wide identification of RNA editing sites in chloroplast transcripts and multiple organellar RNA editing factors in tea plant (Camellia sinensis L.): insights into the albinism mechanism of tea leaves
This study provides a foundation for further reveal in the role of chloroplast RNA editing in albinism process of tea leaves.PMID:36122610 | DOI:10.1016/j.gene.2022.146898 (Source: Gene)
Source: Gene - September 19, 2022 Category: Genetics & Stem Cells Authors: Yuxin Zhao Ruoshi Gao Zhen Zhao Shunkai Hu Rui Han Anburaj Jeyaraj Emmanuel Arkorful Xinghui Li Xuan Chen Source Type: research
Genome-wide identification of RNA editing sites in chloroplast transcripts and multiple organellar RNA editing factors in tea plant (Camellia sinensis L.): insights into the albinism mechanism of tea leaves
This study provides a foundation for further reveal in the role of chloroplast RNA editing in albinism process of tea leaves.PMID:36122610 | DOI:10.1016/j.gene.2022.146898 (Source: Gene)
Source: Gene - September 19, 2022 Category: Genetics & Stem Cells Authors: Yuxin Zhao Ruoshi Gao Zhen Zhao Shunkai Hu Rui Han Anburaj Jeyaraj Emmanuel Arkorful Xinghui Li Xuan Chen Source Type: research
Cysteine protease of < i > Clonorchis sinensis < /i > alleviates DSS-induced colitis in mice
ConclusionsBoth rCsCP andCsCA showed good therapeutic effects on the treatment of acute colitis, but rCsCP is a better choice. rCsCP is a safe, effective, readily available and promising therapeutic agent against IBD mainly by activating innate immunity and regulating the IL-12/IL-23r axis. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - September 9, 2022 Category: Tropical Medicine Authors: Xiaoying Xie Source Type: research
< i > Clonorchis sinensis < /i > infection modulates key cytokines for essential immune response impacted by sex
This study provides a better understanding of how worms affect immune responses and cause a long-term immune alternation in humans withC.sinensis infection. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - September 9, 2022 Category: Tropical Medicine Authors: Shuo Kan Source Type: research
Citrus aurantium ‘Changshan-huyou’—An ethnopharmacological and phytochemical review
Citrus fruits are composed of oil cells layer, white membrane layer, pulp and seeds. The cultivar Citrus aurantium ‘Changshan-huyou’ (CACH) is a hybridization of Citrus grandis Osbeck and C. sinensis Osbeck. It is a rutaceae plant, and mainly grows in Changshan, Zhejiang, China. With the exploration of its high traditional values, it has been paid more and more attention by the scientific community in recent years. At present, one hundred and two chemical constituents have been identified from the pulp and peel of CACH, including volatile oils, terpenoids, phenols, limonins, sugars, etc., As the representative active c...
Source: Frontiers in Pharmacology - September 2, 2022 Category: Drugs & Pharmacology Source Type: research
Relationship between Clonorchis sinensis Infection and Cholangiocarcinoma in Korea
This study provides an overview of the current status of clonorchiasis and cholangiocarcinoma (CCA), and their relationship in Korea during 2012-2020. Data were obtained from the Health Insurance Review & Assessment Service of Korea. Cluster, trend, and correlation analyses were performed. Gyeongsangnam-do and Seoul had the highest average number of cases (1,026 and 4,208) and adjusted rate (306 and 424) for clonorchiasis and CCA, respectively. The most likely clusters (MLC) for clonorchiasis and CCA were Busan/Gyeongsangnam-do/Ulsan/Daegu/Gyeongsangbuk-do (Relative Risk; RR = 4.55, Likelihood Ratio; LLR = 9,131.115) j...
Source: Korean Journal of Parasitology - August 30, 2022 Category: Parasitology Authors: Hwa Sun Kim Ho-Woo Nam Hye-Jin Ahn Dongjae Kim Yeong Hoon Kim Source Type: research
Mapping of the Complement C9 Binding Region on Clonorchis sinensis Paramyosin
Korean J Parasitol. 2022 Aug;60(4):255-259. doi: 10.3347/kjp.2022.60.4.255. Epub 2022 Aug 24.ABSTRACTHeliminthic paramyosin is a multifunctional protein that not only acts as a structural protein in muscle layers but as an immune-modulatory molecule interacting with the host immune system. Previously, we found that paramyosin from Clonorchis sinensis (CsPmy) is bound to human complement C9 protein (C9). To analyze the C9 binding region on CsPmy, overlapping recombinant fragments of CsPmy were produced and their binding activity to human C9 was investigated. The fragmental expression of CsPmy and C9 binding assays revealed ...
Source: Korean Journal of Parasitology - August 30, 2022 Category: Parasitology Authors: Jung-Mi Kang H ương Giang Lê Tu ấn Cường Võ Won Gi Yoo Woon-Mok Sohn Byoung-Kuk Na Source Type: research
Relationship between Clonorchis sinensis Infection and Cholangiocarcinoma in Korea
This study provides an overview of the current status of clonorchiasis and cholangiocarcinoma (CCA), and their relationship in Korea during 2012-2020. Data were obtained from the Health Insurance Review & Assessment Service of Korea. Cluster, trend, and correlation analyses were performed. Gyeongsangnam-do and Seoul had the highest average number of cases (1,026 and 4,208) and adjusted rate (306 and 424) for clonorchiasis and CCA, respectively. The most likely clusters (MLC) for clonorchiasis and CCA were Busan/Gyeongsangnam-do/Ulsan/Daegu/Gyeongsangbuk-do (Relative Risk; RR = 4.55, Likelihood Ratio; LLR = 9,131.115) j...
Source: Korean Journal of Parasitology - August 30, 2022 Category: Parasitology Authors: Hwa Sun Kim Ho-Woo Nam Hye-Jin Ahn Dongjae Kim Yeong Hoon Kim Source Type: research
Mapping of the Complement C9 Binding Region on Clonorchis sinensis Paramyosin
Korean J Parasitol. 2022 Aug;60(4):255-259. doi: 10.3347/kjp.2022.60.4.255. Epub 2022 Aug 24.ABSTRACTHeliminthic paramyosin is a multifunctional protein that not only acts as a structural protein in muscle layers but as an immune-modulatory molecule interacting with the host immune system. Previously, we found that paramyosin from Clonorchis sinensis (CsPmy) is bound to human complement C9 protein (C9). To analyze the C9 binding region on CsPmy, overlapping recombinant fragments of CsPmy were produced and their binding activity to human C9 was investigated. The fragmental expression of CsPmy and C9 binding assays revealed ...
Source: Korean Journal of Parasitology - August 30, 2022 Category: Parasitology Authors: Jung-Mi Kang H ương Giang Lê Tu ấn Cường Võ Won Gi Yoo Woon-Mok Sohn Byoung-Kuk Na Source Type: research
Relationship between Clonorchis sinensis Infection and Cholangiocarcinoma in Korea
This study provides an overview of the current status of clonorchiasis and cholangiocarcinoma (CCA), and their relationship in Korea during 2012-2020. Data were obtained from the Health Insurance Review & Assessment Service of Korea. Cluster, trend, and correlation analyses were performed. Gyeongsangnam-do and Seoul had the highest average number of cases (1,026 and 4,208) and adjusted rate (306 and 424) for clonorchiasis and CCA, respectively. The most likely clusters (MLC) for clonorchiasis and CCA were Busan/Gyeongsangnam-do/Ulsan/Daegu/Gyeongsangbuk-do (Relative Risk; RR = 4.55, Likelihood Ratio; LLR = 9,131.115) j...
Source: Korean Journal of Parasitology - August 30, 2022 Category: Parasitology Authors: Hwa Sun Kim Ho-Woo Nam Hye-Jin Ahn Dongjae Kim Yeong Hoon Kim Source Type: research
Mapping of the Complement C9 Binding Region on Clonorchis sinensis Paramyosin
Korean J Parasitol. 2022 Aug;60(4):255-259. doi: 10.3347/kjp.2022.60.4.255. Epub 2022 Aug 24.ABSTRACTHeliminthic paramyosin is a multifunctional protein that not only acts as a structural protein in muscle layers but as an immune-modulatory molecule interacting with the host immune system. Previously, we found that paramyosin from Clonorchis sinensis (CsPmy) is bound to human complement C9 protein (C9). To analyze the C9 binding region on CsPmy, overlapping recombinant fragments of CsPmy were produced and their binding activity to human C9 was investigated. The fragmental expression of CsPmy and C9 binding assays revealed ...
Source: Korean Journal of Parasitology - August 30, 2022 Category: Parasitology Authors: Jung-Mi Kang H ương Giang Lê Tu ấn Cường Võ Won Gi Yoo Woon-Mok Sohn Byoung-Kuk Na Source Type: research
