Mapping of the Complement C9 Binding Region on Clonorchis sinensis Paramyosin
Korean J Parasitol. 2022 Aug;60(4):255-259. doi: 10.3347/kjp.2022.60.4.255. Epub 2022 Aug 24.ABSTRACTHeliminthic paramyosin is a multifunctional protein that not only acts as a structural protein in muscle layers but as an immune-modulatory molecule interacting with the host immune system. Previously, we found that paramyosin from Clonorchis sinensis (CsPmy) is bound to human complement C9 protein (C9). To analyze the C9 binding region on CsPmy, overlapping recombinant fragments of CsPmy were produced and their binding activity to human C9 was investigated. The fragmental expression of CsPmy and C9 binding assays revealed ...
Source: Korean Journal of Parasitology - August 30, 2022 Category: Parasitology Authors: Jung-Mi Kang H ương Giang Lê Tu ấn Cường Võ Won Gi Yoo Woon-Mok Sohn Byoung-Kuk Na Source Type: research
Relationship between Clonorchis sinensis Infection and Cholangiocarcinoma in Korea
This study provides an overview of the current status of clonorchiasis and cholangiocarcinoma (CCA), and their relationship in Korea during 2012-2020. Data were obtained from the Health Insurance Review & Assessment Service of Korea. Cluster, trend, and correlation analyses were performed. Gyeongsangnam-do and Seoul had the highest average number of cases (1,026 and 4,208) and adjusted rate (306 and 424) for clonorchiasis and CCA, respectively. The most likely clusters (MLC) for clonorchiasis and CCA were Busan/Gyeongsangnam-do/Ulsan/Daegu/Gyeongsangbuk-do (Relative Risk; RR = 4.55, Likelihood Ratio; LLR = 9,131.115) j...
Source: Korean Journal of Parasitology - August 30, 2022 Category: Parasitology Authors: Hwa Sun Kim Ho-Woo Nam Hye-Jin Ahn Dongjae Kim Yeong Hoon Kim Source Type: research
Mapping of the Complement C9 Binding Region on Clonorchis sinensis Paramyosin
Korean J Parasitol. 2022 Aug;60(4):255-259. doi: 10.3347/kjp.2022.60.4.255. Epub 2022 Aug 24.ABSTRACTHeliminthic paramyosin is a multifunctional protein that not only acts as a structural protein in muscle layers but as an immune-modulatory molecule interacting with the host immune system. Previously, we found that paramyosin from Clonorchis sinensis (CsPmy) is bound to human complement C9 protein (C9). To analyze the C9 binding region on CsPmy, overlapping recombinant fragments of CsPmy were produced and their binding activity to human C9 was investigated. The fragmental expression of CsPmy and C9 binding assays revealed ...
Source: Korean Journal of Parasitology - August 30, 2022 Category: Parasitology Authors: Jung-Mi Kang H ương Giang Lê Tu ấn Cường Võ Won Gi Yoo Woon-Mok Sohn Byoung-Kuk Na Source Type: research
Bailing capsule (Cordyceps sinensis) ameliorates renal triglyceride accumulation through the PPAR α pathway in diabetic rats
In conclusion, Bailing Capsule could attenuate renal triglyceride accumulation in diabetic rats by moderating PPARα pathway. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - August 25, 2022 Category: Drugs & Pharmacology Source Type: research
Low Treatment Rates of Parasitic Diseases with Standard-of-Care Prescription Drugs in the United States, 2013-2019
Am J Trop Med Hyg. 2022 Aug 22:tpmd220291. doi: 10.4269/ajtmh.22-0291. Online ahead of print.ABSTRACTTo assess appropriate drug treatment of parasitic diseases in the United States, we examined the treatment rates of 11 selected parasitic infections with standard-of-care prescription drugs and compared them to the treatment rates of two more common bacterial infections (Clostridioides difficile and streptococcal pharyngitis). We used the 2013 to 2019 IBM® MarketScan® Commercial Claims and Encounters and MarketScan® Multi-State Medicaid databases, which included up to 7 years of data for approximately 88 million and 17 m...
Source: The American Journal of Tropical Medicine and Hygiene - August 22, 2022 Category: Tropical Medicine Authors: Heesoo Joo Brian A Maskery Jonathan D Alpern Rebecca J Chancey Michelle Weinberg William M Stauffer Source Type: research
Low Treatment Rates of Parasitic Diseases with Standard-of-Care Prescription Drugs in the United States, 2013-2019
Am J Trop Med Hyg. 2022 Aug 22:tpmd220291. doi: 10.4269/ajtmh.22-0291. Online ahead of print.ABSTRACTTo assess appropriate drug treatment of parasitic diseases in the United States, we examined the treatment rates of 11 selected parasitic infections with standard-of-care prescription drugs and compared them to the treatment rates of two more common bacterial infections (Clostridioides difficile and streptococcal pharyngitis). We used the 2013 to 2019 IBM® MarketScan® Commercial Claims and Encounters and MarketScan® Multi-State Medicaid databases, which included up to 7 years of data for approximately 88 million and 17 m...
Source: Am J Trop Med Hyg - August 22, 2022 Category: Infectious Diseases Authors: Heesoo Joo Brian A Maskery Jonathan D Alpern Rebecca J Chancey Michelle Weinberg William M Stauffer Source Type: research
Low Treatment Rates of Parasitic Diseases with Standard-of-Care Prescription Drugs in the United States, 2013-2019
Am J Trop Med Hyg. 2022 Aug 22:tpmd220291. doi: 10.4269/ajtmh.22-0291. Online ahead of print.ABSTRACTTo assess appropriate drug treatment of parasitic diseases in the United States, we examined the treatment rates of 11 selected parasitic infections with standard-of-care prescription drugs and compared them to the treatment rates of two more common bacterial infections (Clostridioides difficile and streptococcal pharyngitis). We used the 2013 to 2019 IBM® MarketScan® Commercial Claims and Encounters and MarketScan® Multi-State Medicaid databases, which included up to 7 years of data for approximately 88 million and 17 m...
Source: The American Journal of Tropical Medicine and Hygiene - August 22, 2022 Category: Tropical Medicine Authors: Heesoo Joo Brian A Maskery Jonathan D Alpern Rebecca J Chancey Michelle Weinberg William M Stauffer Source Type: research
Low Treatment Rates of Parasitic Diseases with Standard-of-Care Prescription Drugs in the United States, 2013-2019
Am J Trop Med Hyg. 2022 Aug 22:tpmd220291. doi: 10.4269/ajtmh.22-0291. Online ahead of print.ABSTRACTTo assess appropriate drug treatment of parasitic diseases in the United States, we examined the treatment rates of 11 selected parasitic infections with standard-of-care prescription drugs and compared them to the treatment rates of two more common bacterial infections (Clostridioides difficile and streptococcal pharyngitis). We used the 2013 to 2019 IBM® MarketScan® Commercial Claims and Encounters and MarketScan® Multi-State Medicaid databases, which included up to 7 years of data for approximately 88 million and 17 m...
Source: Am J Trop Med Hyg - August 22, 2022 Category: Infectious Diseases Authors: Heesoo Joo Brian A Maskery Jonathan D Alpern Rebecca J Chancey Michelle Weinberg William M Stauffer Source Type: research
Low Treatment Rates of Parasitic Diseases with Standard-of-Care Prescription Drugs in the United States, 2013-2019
Am J Trop Med Hyg. 2022 Aug 22:tpmd220291. doi: 10.4269/ajtmh.22-0291. Online ahead of print.ABSTRACTTo assess appropriate drug treatment of parasitic diseases in the United States, we examined the treatment rates of 11 selected parasitic infections with standard-of-care prescription drugs and compared them to the treatment rates of two more common bacterial infections (Clostridioides difficile and streptococcal pharyngitis). We used the 2013 to 2019 IBM® MarketScan® Commercial Claims and Encounters and MarketScan® Multi-State Medicaid databases, which included up to 7 years of data for approximately 88 million and 17 m...
Source: The American Journal of Tropical Medicine and Hygiene - August 22, 2022 Category: Tropical Medicine Authors: Heesoo Joo Brian A Maskery Jonathan D Alpern Rebecca J Chancey Michelle Weinberg William M Stauffer Source Type: research
Low Treatment Rates of Parasitic Diseases with Standard-of-Care Prescription Drugs in the United States, 2013-2019
Am J Trop Med Hyg. 2022 Aug 22:tpmd220291. doi: 10.4269/ajtmh.22-0291. Online ahead of print.ABSTRACTTo assess appropriate drug treatment of parasitic diseases in the United States, we examined the treatment rates of 11 selected parasitic infections with standard-of-care prescription drugs and compared them to the treatment rates of two more common bacterial infections (Clostridioides difficile and streptococcal pharyngitis). We used the 2013 to 2019 IBM® MarketScan® Commercial Claims and Encounters and MarketScan® Multi-State Medicaid databases, which included up to 7 years of data for approximately 88 million and 17 m...
Source: Am J Trop Med Hyg - August 22, 2022 Category: Infectious Diseases Authors: Heesoo Joo Brian A Maskery Jonathan D Alpern Rebecca J Chancey Michelle Weinberg William M Stauffer Source Type: research
Low Treatment Rates of Parasitic Diseases with Standard-of-Care Prescription Drugs in the United States, 2013-2019
Am J Trop Med Hyg. 2022 Aug 22:tpmd220291. doi: 10.4269/ajtmh.22-0291. Online ahead of print.ABSTRACTTo assess appropriate drug treatment of parasitic diseases in the United States, we examined the treatment rates of 11 selected parasitic infections with standard-of-care prescription drugs and compared them to the treatment rates of two more common bacterial infections (Clostridioides difficile and streptococcal pharyngitis). We used the 2013 to 2019 IBM® MarketScan® Commercial Claims and Encounters and MarketScan® Multi-State Medicaid databases, which included up to 7 years of data for approximately 88 million and 17 m...
Source: The American Journal of Tropical Medicine and Hygiene - August 22, 2022 Category: Tropical Medicine Authors: Heesoo Joo Brian A Maskery Jonathan D Alpern Rebecca J Chancey Michelle Weinberg William M Stauffer Source Type: research
Low Treatment Rates of Parasitic Diseases with Standard-of-Care Prescription Drugs in the United States, 2013-2019
Am J Trop Med Hyg. 2022 Aug 22:tpmd220291. doi: 10.4269/ajtmh.22-0291. Online ahead of print.ABSTRACTTo assess appropriate drug treatment of parasitic diseases in the United States, we examined the treatment rates of 11 selected parasitic infections with standard-of-care prescription drugs and compared them to the treatment rates of two more common bacterial infections (Clostridioides difficile and streptococcal pharyngitis). We used the 2013 to 2019 IBM® MarketScan® Commercial Claims and Encounters and MarketScan® Multi-State Medicaid databases, which included up to 7 years of data for approximately 88 million and 17 m...
Source: Am J Trop Med Hyg - August 22, 2022 Category: Infectious Diseases Authors: Heesoo Joo Brian A Maskery Jonathan D Alpern Rebecca J Chancey Michelle Weinberg William M Stauffer Source Type: research
Low Treatment Rates of Parasitic Diseases with Standard-of-Care Prescription Drugs in the United States, 2013-2019
Am J Trop Med Hyg. 2022 Aug 22:tpmd220291. doi: 10.4269/ajtmh.22-0291. Online ahead of print.ABSTRACTTo assess appropriate drug treatment of parasitic diseases in the United States, we examined the treatment rates of 11 selected parasitic infections with standard-of-care prescription drugs and compared them to the treatment rates of two more common bacterial infections (Clostridioides difficile and streptococcal pharyngitis). We used the 2013 to 2019 IBM® MarketScan® Commercial Claims and Encounters and MarketScan® Multi-State Medicaid databases, which included up to 7 years of data for approximately 88 million and 17 m...
Source: The American Journal of Tropical Medicine and Hygiene - August 22, 2022 Category: Tropical Medicine Authors: Heesoo Joo Brian A Maskery Jonathan D Alpern Rebecca J Chancey Michelle Weinberg William M Stauffer Source Type: research
Low Treatment Rates of Parasitic Diseases with Standard-of-Care Prescription Drugs in the United States, 2013-2019
Am J Trop Med Hyg. 2022 Aug 22:tpmd220291. doi: 10.4269/ajtmh.22-0291. Online ahead of print.ABSTRACTTo assess appropriate drug treatment of parasitic diseases in the United States, we examined the treatment rates of 11 selected parasitic infections with standard-of-care prescription drugs and compared them to the treatment rates of two more common bacterial infections (Clostridioides difficile and streptococcal pharyngitis). We used the 2013 to 2019 IBM® MarketScan® Commercial Claims and Encounters and MarketScan® Multi-State Medicaid databases, which included up to 7 years of data for approximately 88 million and 17 m...
Source: Am J Trop Med Hyg - August 22, 2022 Category: Infectious Diseases Authors: Heesoo Joo Brian A Maskery Jonathan D Alpern Rebecca J Chancey Michelle Weinberg William M Stauffer Source Type: research
Low Treatment Rates of Parasitic Diseases with Standard-of-Care Prescription Drugs in the United States, 2013-2019
Am J Trop Med Hyg. 2022 Aug 22:tpmd220291. doi: 10.4269/ajtmh.22-0291. Online ahead of print.ABSTRACTTo assess appropriate drug treatment of parasitic diseases in the United States, we examined the treatment rates of 11 selected parasitic infections with standard-of-care prescription drugs and compared them to the treatment rates of two more common bacterial infections (Clostridioides difficile and streptococcal pharyngitis). We used the 2013 to 2019 IBM® MarketScan® Commercial Claims and Encounters and MarketScan® Multi-State Medicaid databases, which included up to 7 years of data for approximately 88 million and 17 m...
Source: The American Journal of Tropical Medicine and Hygiene - August 22, 2022 Category: Tropical Medicine Authors: Heesoo Joo Brian A Maskery Jonathan D Alpern Rebecca J Chancey Michelle Weinberg William M Stauffer Source Type: research
