Megabladder mouse model may help predict severity of pediatric kidney damage
A new study of the megabladder mouse model suggests that tracking changes in the expression of key genes involved in kidney disease could help physicians predict the severity of urinary tract obstruction in pediatric patients, which could help identify children at the greatest risk of chronic kidney disease and permanent organ damage. The work was led by a team that includes Brian Becknell, MD, PhD, a clinician and assistant professor in the Division of Nephrology at Nationwide Children's Hospital... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 9, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Relationship of kidney function estimates to risk improves by measuring cystatin C in the blood
A new, international study from the Chronic Kidney Disease Prognosis Consortium found that use of blood levels of cystatin C to estimate kidney function - alone or in combination with creatinine - strengthens the association between kidney function and risks of death and end-stage renal disease. The findings, reported in the September 5 edition of the New England Journal of Medicine, suggest that the use of cystatin C as a measurement of kidney function could lead to better staging and risk classification of chronic kidney disease... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 9, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Researchers target muscle wasting in chronic kidney disease
Baylor College of Medicine researchers have identified in mouse models and patient muscle biopsies a new signaling pathway that could lead to a way of blocking the protein believed to be behind muscle wasting. (Source: Baylor College of Medicine News)
Source: Baylor College of Medicine News - September 5, 2013 Category: Universities & Medical Training Source Type: news

Rockwell Medical's Iron Deficiency Drug Succeeds in Final StudyRockwell Medical's Iron Deficiency Drug Succeeds in Final Study
Rockwell Medical Inc said its lead experimental drug met the main goal of improving hemoglobin levels in its final late-stage trial among adult patients with chronic kidney disease. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 4, 2013 Category: Consumer Health News Tags: Nephrology News Source Type: news

Rockwell Medical's iron deficiency drug succeeds in final study
(Reuters) - Rockwell Medical Inc said its lead experimental drug met the main goal of improving hemoglobin levels in its final late-stage trial among adult patients with chronic kidney disease. (Source: Reuters: Health)
Source: Reuters: Health - September 4, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Rockwell Medical's iron deficiency drug succeeds in second late-stage study
(Reuters) - Rockwell Medical Inc said its lead experimental drug met the main goal of improving hemoglobin levels in its final late-stage trial among adult patients with chronic kidney disease. (Source: Reuters: Health)
Source: Reuters: Health - September 4, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Relationship of kidney function estimates to risk improves by measuring cystatin C in the blood
(Johns Hopkins University Bloomberg School of Public Health) A new, international study that use of blood levels of cystatin C to estimate kidney function -- alone or in combination with creatinine -- strengthens the association between kidney function and risks of death and end-stage renal disease. The findings suggest that the use of cystatin C as a measurement of kidney function could lead to better staging and risk classification of chronic kidney disease. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - September 4, 2013 Category: Global & Universal Source Type: news

Better kidney care could save thousands of lives
Conclusion You can’t always prevent all causes of AKI but you can take steps to improve the general health of your kidneys. These include: stay hydrated maintain a healthy blood pressure eat a healthy diet avoid smoking and drinking excessive amounts of alcohol try to maintain a healthy weight For more information and advice visit the NHS Choices Kidney health hub Analysis by Bazian. Edited by NHS Choices. Follow Behind the Headlines on Twitter.  Links To The Headlines Kidney checks on hospital patients 'would save lives'. BBC News, August 28 2013 Thousands dying of thirst on NH...
Source: NHS News Feed - August 28, 2013 Category: Consumer Health News Tags: Medical practice QA articles Source Type: news

Patients with moderate kidney disease can safely exercise
A structured exercise and lifestyle program can improve fitness, body composition, and heart function in patients with kidney disease, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The findings suggest that patients with kidney disease can benefit from greater physical activity and can do so safely even though they may have other medical problems. Approximately 60 million people globally have chronic kidney disease (CKD)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 26, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Caveat for blood pressure treatment in chronic kidney disease
Physicians should keep a close eye on diastolic blood pressure when attempting to reduce systolic blood pressure in patients who have chronic kidney disease, research suggests. (Source: MedWire News - Hypertension)
Source: MedWire News - Hypertension - August 25, 2013 Category: Cardiology Source Type: news

Caveat for blood pressure treatment in chronic kidney disease
Physicians should keep a close eye on diastolic blood pressure when attempting to reduce systolic blood pressure in patients who have chronic kidney disease, research suggests. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - August 25, 2013 Category: Cardiology Source Type: news

Exercise Boosts Heart Health in Renal Disease (CME/CE)
(MedPage Today) -- Regular exercise improved cardiac functioning in patients with chronic kidney disease in the largest CKD intervention study to date. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - August 23, 2013 Category: Consumer Health News Source Type: news

Kidney Disease Patients Can Benefit from Exercise
Program created specifically for people with multiple health issues was safe, boosted fitness Source: HealthDay Related MedlinePlus Pages: Chronic Kidney Disease, Exercise and Physical Fitness (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - August 22, 2013 Category: Consumer Health News Source Type: news

Low BP May Be Fatal in CKD (CME/CE)
(MedPage Today) -- Chronic kidney disease patients, including those with diabetes, who were not on dialysis were more likely to die when blood pressure was too low, even if only on the diastolic measure, a veterans cohort showed. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 20, 2013 Category: Cardiology Source Type: news

Tight BP Control May Be Deadly for Older Patients With CKDTight BP Control May Be Deadly for Older Patients With CKD
A large observational study of elderly veterans with chronic kidney disease points to the danger of aiming to lower systolic and diastolic blood pressures to meet guidelines--especially in patients with already-low diastolic blood pressure. Heartwire (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 20, 2013 Category: Consumer Health News Tags: Cardiology News Source Type: news

Too-low diastolic blood pressure can be deadly for CKD patients
Having too-low diastolic blood pressure (DBP) may be deadly for patients with chronic kidney disease (CKD). Blood pressure (BP) recommendations are stricter for patients with CKD than for the general population and focus on lowering actual BP (the measurement of both systolic BP [SBP] and DBP) without consideration for achieving a DBP that is too low. Researchers reviewed health records for 651,749 U.S. veterans with CKD to assess the association between BP and death. Both actual BP and measurements of SBP and DBP considered separately were assessed... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 20, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Low Diastolic BP Associated with Higher Mortality in Chronic Kidney Disease (FREE)
By Joe Elia The association of blood pressure with mortality in chronic kidney disease seems to follow a J-shaped curve, especially with regard to diastolic pressure, according to an Annals of Internal Medicine study.Researchers followed … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - August 20, 2013 Category: Primary Care Source Type: news

Tight BP control may be deadly for older patients with CKD
A large observational study of elderly veterans with chronic kidney disease points to the danger of aiming to lower systolic and diastolic blood pressures to meet guidelines—especially in patients with already-low diastolic blood pressure. (Source: theHeart.org)
Source: theHeart.org - August 19, 2013 Category: Cardiology Source Type: news

Healthy Diet Lowers CKD Risk in Type 2 Diabetics
(Ivanhoe Newswire) – A recent study reports that drinking a moderate amount of alcohol and eating a healthy diet may be associated with decreased risk of progression of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - August 19, 2013 Category: Consumer Health News Source Type: news

Healthy Diet Lowers CKD Risk in Type 2 Diabetes PatientsHealthy Diet Lowers CKD Risk in Type 2 Diabetes Patients
Higher fruit and vegetable consumption and moderate alcohol intake significantly reduced the risk for chronic kidney disease in patients with type 2 diabetes in a substudy of ONTARGET. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 13, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Right Diet May Cut Kidney Risk in Diabetes (CME/CE)
(MedPage Today) -- A healthy diet was associated with a lower risk of incidence or progression of chronic kidney disease in people with type 2 diabetes, researchers reported. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 13, 2013 Category: Cardiology Source Type: news

Mastix Medica Introduces RenaGumâ„¢ - The First Medical Food Chewing Gum
RenaGum™ is a new approach to helping people with chronic kidney disease (CKD) maintain normal phosphate levels. It is the first medical food that is not another pill or tablet you need to swallow,...(PRWeb August 08, 2013)Read the full story at http://www.prweb.com/releases/2013/8/prweb11010469.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - August 11, 2013 Category: Pharmaceuticals Source Type: news

Medicare's CKD Bill: $49 Billion a Year (CME/CE)
(MedPage Today) -- Estimates for Medicare expenditures in chronic kidney disease show costs rise as the disease worsens, topping out at over $12,000 per person and totaling $49 billion annually, researchers found. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - August 2, 2013 Category: Consumer Health News Source Type: news

Statins and the Kidney: Good at All StagesStatins and the Kidney: Good at All Stages
This F1000 commentary reports on a study whose findings conclude that statins should be used in all stages of chronic kidney disease (CKD), including stage 5. Faculty of 1000 (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 2, 2013 Category: Consumer Health News Tags: Nephrology Commentary Source Type: news

Anaemia may be linked to increased dementia risk
"Iron-rich foods such as steak…could cut the risk of dementia in later life, say researchers" is the misleading claim in the Daily Mail. The Daily Telegraph follows suit, stating that scientists claim we should "Eat steak to reduce risk of dementia". But the cohort study that both papers seized on did not actually look directly at diet. The study followed more than 2,550 older adults for over a decade and found that those who had anaemia at the start of the study were more likely to go on to develop dementia. Anaemia is caused by reduced levels of either red blood cells or the...
Source: NHS News Feed - August 1, 2013 Category: Consumer Health News Tags: Food/diet Lifestyle/exercise Neurology Older people Source Type: news

Current Definition of Chronic Kidney Disease Yields Striking Overdiagnoses (FREE)
By Amy Orciari Herman The definition of chronic kidney disease currently used in the U.S. has led to overdiagnosis, with 14% of Americans potentially meeting criteria for CKD, according to a BMJ analysis. Previous definitions … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - July 31, 2013 Category: Primary Care Source Type: news

New definition of chronic kidney disease labels 1 in 8 adults as sick
This article is the second of a series looking at the risks and harms of overdiagnosis in a range of common conditions... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 30, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Astellas and FibroGen begins Phase II study of ASP1517/FG-4592 in Japan
Astellas Pharma and FibroGen have started a Phase II study of ASP1517/FG-4592 to treat anaemia of chronic kidney disease (CKD) in patients on dialysis in Japan. (Source: Drug Development Technology)
Source: Drug Development Technology - July 30, 2013 Category: Pharmaceuticals Source Type: news

Analysis: Overdiagnosis in CKD? (CME/CE)
(MedPage Today) -- Expanded criteria for chronic kidney disease (CKD) have labeled too many people as sick, researchers argued. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - July 30, 2013 Category: Endocrinology Source Type: news

NIH expands study to better understand kidney disease progression
Research will examine the roll chronic kidney disease may play in hospitalization for other illnesses. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - July 29, 2013 Category: American Health Source Type: news

NIH expands study to better understand kidney disease progression
(NIH/National Institute of Diabetes and Digestive and Kidney Diseases) Researchers from the Chronic Renal Insufficiency Cohort (CRIC) study are embarking on another five years of work to identify risk factors for progression of early stage chronic kidney disease (CKD), better understand the importance of reduced kidney function in older persons, and learn what role CKD may play in other illnesses that require hospitalization. CRIC is supported by the National Institutes of Health. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 29, 2013 Category: Global & Universal Source Type: news

Great CPC: Metformin toxicity
3.5 out of 5 stars Case 23-2013: a 54-Year-old Woman with Abdominal Pain, Vomiting, and Confusion. Kalantar-Zadeh K et al. N Engl J Med 2013 Jul 25;369:374-382. Full Text This is a very instructive case discussion from the Massachusetts General Hospital. A plane was diverted to Boston because one passenger, a 54-year-old woman, developed increasing abdominal pain and vomiting, along with decreasing mental status. After the plane landed, EMS found that here vital signs were fairly unremarkable (HR = 52 bpm). She was not hypoglycemic. Her medical history included type-2 diabetes, hypertension, and chronic renal disease....
Source: The Poison Review - July 26, 2013 Category: Toxicology Authors: Leon Tags: Medical acute pancreatitis anion gap metabolic acidosis case discussion case records of the massachusetts general hospital metformin toxicity Source Type: news

CKD: Calcium-Based Phosphate Binders May Increase MortalityCKD: Calcium-Based Phosphate Binders May Increase Mortality
Noncalcium-based phosphate binders are associated with a lower risk for all-cause mortality in patients with chronic kidney disease compared with calcium-based phosphate binders. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 25, 2013 Category: Consumer Health News Tags: Nephrology News Source Type: news

Guidelines on Managing Anemia in CKDGuidelines on Managing Anemia in CKD
What do the latest clinical guidelines say about the treatment of anemia in chronic kidney disease? Are there any new therapeutic strategies? Nephrology Dialysis Transplantation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 24, 2013 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

In patients with kidney disease, calcium linked to increased risk of heart disease and death
Kidney patients who take calcium supplements to lower their phosphorous levels may be at a 22 per cent higher risk of death than those who take other non-calcium based treatments, according to a new study by Women's College Hospital's Dr. Sophie Jamal. The study, published in the Lancet, calls into question the long-time practice of prescribing calcium to lower phosphate levels in patients with chronic kidney disease... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 24, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Medication-resistant hypertension present in most people with moderate kidney disease
More than 50% of individuals with moderate kidney disease have hypertension that is resistant to medications, and those who are black or have a larger waist circumference, diabetes, or a history of heart attacks or strokes are at highest risk, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The findings could help identify kidney disease patients who need more intensive monitoring and treatments for hypertension. Approximately 60 million people globally have chronic kidney disease (CKD)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 22, 2013 Category: Consumer Health News Tags: Hypertension Source Type: news

CKD May Up Risk of Resistant Hypertension (CME/CE)
(MedPage Today) -- Patients with chronic kidney disease are at risk for treatment-resistant hypertension, although certain subgroups carry a higher risk than others, researchers found. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - July 18, 2013 Category: Consumer Health News Source Type: news

CKD May Increase Risk of Resistant Hypertension (CME/CE)
(MedPage Today) -- Patients with chronic kidney disease are at risk for treatment-resistant hypertension, although certain subgroups carry a higher risk than others, researchers found. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - July 18, 2013 Category: Consumer Health News Source Type: news

Kidney Function Declines Faster in Black Patients (CME/CE)
(MedPage Today) -- Even in a universal healthcare system that presumably provides equal care to all people, blacks with chronic kidney disease had faster progression to end-stage renal disease than their white counterparts, a Dutch study showed. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - July 15, 2013 Category: Consumer Health News Source Type: news

Novel Drug Bendavia Acts In Unique Way To Protect Against Kidney Injury
New research reveals the mechanism by which an experimental drug can protect the kidneys from sudden damage, called acute kidney injury (AKI). The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), show how the drug may be able to save many lives and cut medical costs related to the condition. AKI, which affects millions of people worldwide and increases the risk of developing chronic kidney disease and dying early, is most often caused by reduced or blocked blood flow to the kidney (called ischemia)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 15, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

New Iron Formula Boosts Hb During Dialysis
(MedPage Today) -- An investigational iron replacement agent significantly raised hemoglobin levels compared with placebo among dialysis patients with chronic kidney disease, according to top-line results from a trial. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - July 11, 2013 Category: Endocrinology Source Type: news

Rockwell Medical's iron deficiency drug succeeds in trial
(Reuters) - Rockwell Medical Inc said a late-stage trial of its experimental iron deficiency drug met the main goal of improving hemoglobin levels in patients with chronic kidney disease. (Source: Reuters: Health)
Source: Reuters: Health - July 11, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

FIND-CKD Study Demonstrates That Ferinject® Reduces Need For Alternative Anaemia Treatment
The FIND-CKD study was designed to investigate the optimal route of administration and dosing strategy for iron therapy in patients with non-dialysis-dependent chronic kidney disease (ND-CKD) suffering from iron deficiency anaemia. Ferinject® (ferric carboxymaltose) was compared to oral iron treatment. The study met its primary endpoint, thereby demonstrating that Ferinject® reduces the need for other anaemia management (e.g. erythropoiesis-stimulating agents (ESAs) or blood transfusion) in this patient population... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 11, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

CKD: Holistic Care May Improve Low QOL in Young PatientsCKD: Holistic Care May Improve Low QOL in Young Patients
Adolescents and young adults with chronic kidney disease have low QOL and are willing to trade life expectancy for perfect health; holistic care may improve QOL and health outcomes. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 29, 2013 Category: Consumer Health News Tags: Nephrology News Source Type: news

L-thyroxine Dampens Renal Function Decline in CKD With SCHL-thyroxine Dampens Renal Function Decline in CKD With SCH
Thyroid hormone replacement therapy might dampen the rate of decline in renal function in patients with stage 2 to 4 chronic kidney disease and subclinical hypothyroidism, researchers report. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 19, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

IV Iron in CKD: Understanding the GuidelinesIV Iron in CKD: Understanding the Guidelines
Dr. Jeffrey Berns provides perspective on sections in the KDIGO guidelines on managing chronic kidney disease that deal with intravenous iron. Medscape Nephrology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2013 Category: Consumer Health News Tags: Nephrology Commentary Source Type: news

Serum Bicarbonate and Mortality in AdultsSerum Bicarbonate and Mortality in Adults
Is low serum bicarbonate concentration a strong risk factor for mortality in patients with or without chronic kidney disease? Nephrology Dialysis Transplantation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2013 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

Sleep Problems Common in Chronic Kidney DiseaseSleep Problems Common in Chronic Kidney Disease
Research suggests an 'unmet need' for the assessment and treatment of sleep disorders in patients with kidney disease, researchers say. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 5, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Diabetes Poses Greatest Kidney Risk (CME/CE)
(MedPage Today) -- Diabetes is the most common cause of chronic kidney disease worldwide, though herbal and environmental toxins are also to blame, especially in developing countries, researchers found. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - May 31, 2013 Category: Cardiology Source Type: news

In End-Stage Heart Failure, Levosimendan Improves Event Free Survival By 50 Percent
Ambulatory levosimendan improves event free survival by 50% compared to placebo, according to results from the LevoRep Study presented during a late breaking trial session of the Heart Failure Congress 2013. In a second study, the third generation mineralocorticoid receptor antagonist (MRA) BAY 94-8862 showed improved potassium and kidney tolerance in heart failure patients with chronic kidney disease (CKD). Heart Failure 2013 is the main annual meeting of the Heart Failure Association of the European Society of Cardiology and was held 25-28 May in Lisbon, Portugal... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 29, 2013 Category: Consumer Health News Tags: Heart Disease Source Type: news