AstraZeneca, MedImmune, Lilly join U-M to discover new CKD treatments
AstraZeneca and its global biologics research and development arm MedImmune have entered into collaboration with the University of Michigan and Eli Lilly to discover new therapeutic targets to treat chronic kidney diseases (CKD). (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - February 12, 2016 Category: Pharmaceuticals Source Type: news

Fresenius’ Frenova launches clinical trial accelerator
Dialysis giant Fresenius‘s (NYSE:FMS) renal research branch Frenova said today it launched a renal research accelerator, titled F1RST Up, through an alliance of physician investigators in the nephrology research field. The accelerator aims to boost study startup through the elimination of administrative and contracting burdens that plague clinical trials, and are often responsible for delays, the Waltham, Mass.-based company said. “F1RST Up was conceived and organized with value for all of our stakeholders in mind. We worked very closely with our F1RST Up physician partners and clients to both identify and...
Source: Mass Device - February 11, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Clinical Trials Frenova Renal Research Fresenius Medical Care Source Type: news

REVOKE IV Iron or FIND-CKD Patients?REVOKE IV Iron or FIND-CKD Patients?
Dr Jeffrey Berns discusses inconsistencies in the clinical trial evidence comparing intravenous iron with oral iron in patients with chronic kidney disease not on dialysis. Medscape Nephrology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 11, 2016 Category: Consumer Health News Tags: Nephrology Commentary Source Type: news

No Such Thing as 'Fat and Fit'? High BMI Associated With CKDNo Such Thing as 'Fat and Fit'? High BMI Associated With CKD
Higher body mass indices were associated with chronic kidney disease in a large Korean cohort of otherwise metabolically healthy participants. Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - February 9, 2016 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Beat Depression to Stay Healthier & Live Longer: A Guide for Older Adults & Their Families
Many people find the reality of getting older depressing. And depression itself often comes with a stigma. So when we talk about depression and aging combined, what results is a very complicated — and often hard to treat — issue. Gary S. Moak, former president of the American Association for Geriatric Psychiatry, has written a new book to help. Beat Depression to Stay Healthier and Live Longer: A Guide for Older Adults and Their Families combines Moak’s years of experience working with elderly populations with the latest research on depression. Moak begins by defining depress...
Source: Psych Central - January 28, 2016 Category: Psychiatry Authors: Claire Nana Tags: Aging Antidepressants Book Reviews Depression Family General Psychology Self-Help Seniors Treatment antidepressants for elderly patients antidepressants for old people beat depression depression and aging depression geriatric Source Type: news

Pharmacists key to detecting chronic kidney disease in at-risk patients
(Canadian Pharmacists Association) Pharmacists who screened at-risk patients for chronic kidney disease found previously unrecognized disease in 1 of every 6.4 patients tested, according to a study to be published in the January/February 2016 issue of the Canadian Pharmacists Journal. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 26, 2016 Category: Global & Universal Source Type: news

Mitochondrial DNA Levels in the Blood May Predict Risk of Developing Chronic Kidney Disease
High levels of mitochondrial DNA in the blood was linked with a 25% reduced risk of developing chronic kidney disease compared with low levels, report researchers at the conclusion of a study. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 22, 2016 Category: Science Source Type: news

Etelcalcetide (calcimimetic) for the Treatment of Secondary Hyperparathyroidism (SHPT)
Etelcalcetide (formerly AMG416), an intravenous injectable calcimimetic agent, is currently under development by Amgen for the treatment of secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD) on haemodialysis. (Source: Drug Development Technology)
Source: Drug Development Technology - January 18, 2016 Category: Pharmaceuticals Source Type: news

Report identifies positive news on kidney disease in the US, yet challenges remain
The annual data report from the United States Renal Data System reveals both positive and negative trends in kidney disease in the US. Medicare spending for patients with chronic kidney disease aged 65 and older exceeded $50 billion in 2013 and represented 20 percent of all Medicare spending in that age group. In addition, the total cost to Medicare for end-stage kidney disease grew to $30.9 billion and accounted for 7.1 percent of the overall paid Medicare claims costs. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 18, 2016 Category: Science Source Type: news

NHS Health Checks 'prevented thousands of heart attacks'
ConclusionThis descriptive study has provided information about how many people took part in the NHS Health Check programme in the first four years it was available. While the uptake was initially relatively low, it is increasing. It is also encouraging that some of the more vulnerable groups – those who are older and those in the most deprived social group – are most likely to attend the checks. There were limitations to the data available. For example, it was not possible to directly assess whether all new prescriptions and treatments after the checks were as a direct result of the checks. The proportion of p...
Source: NHS News Feed - January 15, 2016 Category: Consumer Health News Tags: Heart/lungs Neurology Medical practice Source Type: news

Well: Heartburn Drugs Tied to Kidney Problems
Proton pump inhibitors like Nexium, Prevacid and Prilosec may increase the risk of chronic kidney disease. (Source: NYT)
Source: NYT - January 15, 2016 Category: Nutrition Authors: NICHOLAS BAKALAR Tags: Drugs (Pharmaceuticals) Heartburn Kidneys Live Clostridium Difficile (Bacterium) Featured Source Type: news

Well: Heartburn Drugs Tied to Kidney Problems
Proton pump inhibitors like Nexium, Prevacid and Prilosec may increase the risk of chronic kidney disease. (Source: NYT Health)
Source: NYT Health - January 14, 2016 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Drugs (Pharmaceuticals) Heartburn Kidneys Live Clostridium Difficile (Bacterium) Featured Source Type: news

Medical News Today: Stomach acid drugs linked to chronic kidney disease
A new study finds that use of proton pump inhibitors - drugs commonly used for controlling stomach acid - may be linked to higher risk for chronic kidney disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 13, 2016 Category: Consumer Health News Tags: Acid Reflux / GERD Source Type: news

NHS Health Check study estimates 2,500 heart attacks and strokes prevented over 5 years
(Queen Mary, University of London) The first major evaluation of the NHS Health Check in England, led by Queen Mary University of London, finds that the programme is effectively identifying people at risk of developing a major cardiovascular incident such as heart attack or stroke, and is estimated over first five years to have prevented 2,500 cases from treatment following the check, as well as helping diagnose cases of type 2 diabetes, high blood pressure and chronic kidney disease. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 13, 2016 Category: Global & Universal Source Type: news

Heartburn Medicines Associated with Chronic Kidney Disease Risk
A type of heartburn medication called proton pump inhibitors (PPIs) may be linked to long-term kidney damage, according to a new study published in JAMA Internal Medicine. “This is an important study because millions of Americans are on proton pump inhibitors and have been for many years,” says Kenneth DeVault, M.D., a Mayo Clinic gastroenterologist [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 13, 2016 Category: Research Source Type: news

How Safe Are Heartburn Medications?
This news may give you some heartburn. A study found that a commonly used type of heartburn medication (proton pump inhibitors or PPIs) may be associated with chronic kidney disease. Any concern about PPI safety raises the question of whether more effort should be made to tackle some root causes of heartburn such as obesity and stress. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - January 12, 2016 Category: Pharmaceuticals Authors: Bruce Y. Lee Source Type: news

Heartburn Meds Linked to Chronic Kidney Disease
Title: Heartburn Meds Linked to Chronic Kidney DiseaseCategory: Health NewsCreated: 1/11/2016 12:00:00 AMLast Editorial Review: 1/12/2016 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - January 12, 2016 Category: Nutrition Source Type: news

PPIs Associated with Increased Risk for Chronic Kidney Disease (FREE)
By Kelly Young Edited by Jaye Elizabeth Hefner, MD Use of proton-pump inhibitors (PPIs) is associated with a 20% to 50% increased risk for developing chronic kidney disease (CKD), suggests an observational study in JAMA Internal Medicine.In the main, … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - January 12, 2016 Category: Primary Care Source Type: news

Proton Pump Inhibitors May Increase Risk for Kidney Disease Proton Pump Inhibitors May Increase Risk for Kidney Disease
Proton pump inhibitors such as omeprazole are linked to increased risks for chronic kidney disease and for acute kidney injury, according to two population-based analyses. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 11, 2016 Category: Consumer Health News Tags: Internal Medicine News Source Type: news

PPIs Tied to Increased Risk for Chronic Kidney Disease (CME/CE)
(MedPage Today) -- Whether drugs actually cause CKD remains uncertain (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - January 11, 2016 Category: Urology & Nephrology Source Type: news

Heartburn Meds Linked to Chronic Kidney Disease
While study can't prove cause-and-effect, increasing damage seen as dose rises (Source: WebMD Health)
Source: WebMD Health - January 11, 2016 Category: Consumer Health News Source Type: news

Heartburn Meds Linked to Chronic Kidney Disease
While study can't prove cause-and-effect, increasing damage seen as dose rises Source: HealthDay Related MedlinePlus Pages: Drug Reactions, Heartburn, Kidney Diseases (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - January 11, 2016 Category: Consumer Health News Source Type: news

Kidney injury common following vascular surgery
Both acute kidney injury and chronic kidney disease were common in patients undergoing major vascular surgical procedures and were associated with an increase in long-term cardiovascular-specific death compared with patients with no kidney disease, according to a study. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 23, 2015 Category: Science Source Type: news

The Isolation and Quantitation of Fetuin-A-Containing Calciprotein Particles from Biological Fluids
Multiple overlapping systemic and local inhibitory networks have evolved to prevent the unwanted deposition of mineral at ectopic sites. Fetuin-A is a liver-derived glycoprotein abundant in plasma that binds and stabilizes nascent mineral ion nuclei to form soluble colloidal high molecular weight complexes, called calciprotein particles (CPP). The binding of fetuin-A to mineral retards crystal ripening and precipitation from the aqueous phase, thereby facilitating the regulated clearance of mineral debris from the extracellular fluid. However, persistent disturbances in this humoral homeostatic system, as frequently seen i...
Source: Springer protocols feed by Molecular Medicine - December 22, 2015 Category: Molecular Biology Source Type: news

Vascular Calcification in Uremia: New-Age Concepts about an Old-Age Problem
A hallmark of aging, and major contributor to the increased prevalence of cardiovascular disease in patients with chronic kidney disease (CKD), is the progressive structural and functional deterioration of the arteries and concomitant accrual of mineral. Vascular calcification (VC) was long viewed as a degenerative age-related pathology that resulted from the passive deposition of mineral in the extracellular matrix; however, since the discovery of “bone-related” protein expression in calcified atherosclerotic plaques over 20 years ago, a plethora of studies have evoked the now widely accepted view that VC is a...
Source: Springer protocols feed by Molecular Medicine - December 22, 2015 Category: Molecular Biology Source Type: news

Prolonged and Continuous Measurement of Kidney Oxygenation in Conscious Rats
A relative deficiency in kidney oxygenation, i.e., renal hypoxia, may contribute to the initiation and progression of acute and chronic kidney disease. A critical barrier to investigate this is the lack of methods allowing measurement of the partial pressure of oxygen in kidney tissue for long periods in vivo. We have developed, validated, and tested a novel telemetric method that can do this. Here we provide details on the calibration, implantation, implementation for data recording, and reuse of this telemetry-based technology for measurement of medullary tissue oxygen tension in conscious, unrestrained rats. This techni...
Source: Springer protocols feed by Molecular Medicine - December 22, 2015 Category: Molecular Biology Source Type: news

Kidney-Disease Patients With Dietary Protein From PlantsKidney-Disease Patients With Dietary Protein From Plants
Eating a higher proportion of protein from plant sources like soy, nuts and legumes, rather than animal sources, is tied to reduced mortality risk in people with chronic kidney disease (CKD), according to new research. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 21, 2015 Category: Consumer Health News Tags: Nephrology News Source Type: news

Akebia and Mitsubishi to develop and commercialise CKD drug vadadustat in Asia
US-based Akebia Therapeutics has entered into a development and commercialisation agreement with Mitsubishi Tanabe Pharma (MTPC) for vadadustat (formerly AKB-6548), an oral therapy that treats anaemia related to chronic kidney disease (CKD) in Japan … (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - December 15, 2015 Category: Pharmaceuticals Source Type: news

Ambulatory and Home Blood Pressure Monitoring in People With CKDAmbulatory and Home Blood Pressure Monitoring in People With CKD
How important is out of office BP data for patients with chronic kidney disease? Current Opinion in Nephrology and Hypertension (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 11, 2015 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

Thyroid Dysfunction and Dyslipidemia in CKD PatientsThyroid Dysfunction and Dyslipidemia in CKD Patients
Find out more about the prevalence of thyroid and lipid disorders in patients with chronic kidney disease -- and how these complications may contribute to the risk for cardiovascular disease. BMC Endocrine Disorders (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 8, 2015 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

Study reveals non-invasive warning sign of kidney disease progression
Researchers have identified an accessible, non-invasive way to identify patients at risk for progression of kidney disease. Chronic kidney disease is a condition in which damaged kidneys cannot filter blood as well as healthy kidneys. Currently, it is estimated that over 10 million individuals suffer from chronic kidney disease, with the number of those affected continuing to rise. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 3, 2015 Category: Science Source Type: news

Biomarkers of Rapid CKD Progression in Type 2 DiabetesBiomarkers of Rapid CKD Progression in Type 2 Diabetes
Which biomarkers show rapid progression of chronic kidney disease in patients with type 2 diabetes? Kidney International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 27, 2015 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

Blood phosphorus levels can help predict kidney failure risk in African Americans
An increase in serum phosphorus levels in African Americans with chronic kidney disease (CKD) is associated with faster progression to kidney failure, known as end-stage renal disease (ESRD). The study confirmed in African Americans what previous studies in Caucasians demonstrated, that an increase in the biomarker predicted ESRD risk. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 17, 2015 Category: Science Source Type: news

Blood phosphorus levels can help predict kidney failure risk in African-Americans
(American Society of Nephrology) An increase in serum phosphorus levels in African-Americans with chronic kidney disease is associated with faster progression to kidney failure, known as end-stage renal disease (ESRD). The study confirmed in African-Americans what previous studies in Caucasians demonstrated, that an increase in the biomarker predicted ESRD risk. The research, from the Indiana University School of Medicine, was presented at ASN Kidney Week 2015 Nov. 3-8 at the San Diego Convention Center in San Diego, CA. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 17, 2015 Category: Global & Universal Source Type: news

Is 120 mm Hg the new BP target? What headlines aren’t telling you
The results of the SPRINT trial are in, and you’ve probably heard that making 120 mm Hg the new blood pressure target helped lower mortality rates. Yet the study outcomes apply only to a specific subset of patients with hypertension. See whether or not your patients may fit into this category. In the much-anticipated results of the SPRINT trial, the relative risk of death from cardiovascular causes was 43 percent lower for patients receiving more intensive treatment for a 120 mm Hg target versus those who received standard treatment for a 140 mm Hg target. While these results were unexpected and are noteworthy...
Source: AMA Wire - November 11, 2015 Category: Journals (General) Authors: amamod Source Type: news

Penn researchers present findings on cardiac risks for patients with chronic kidney disease
(University of Pennsylvania School of Medicine) Chronic Kidney Disease (CKD), which afflicts more than 26 million Americans, is a condition in which individuals experience a slow loss of kidney function over time. At the American Heart Association Scientific Sessions 2015, researchers from the Perelman School of Medicine at the University of Pennsylvania today presented findings from their analysis of the Chronic Renal Insufficiency Cohort study to evaluate risk markers for adverse cardiac events in patients with CKD. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 10, 2015 Category: Global & Universal Source Type: news

Penn researchers present findings on cardiac risks for patients with chronic kidney disease
(University of Pennsylvania School of Medicine) Chronic kidney disease (CKD), which afflicts more than 26 million Americans, is a condition in which individuals experience a slow loss of kidney function over time. At the American Heart Association Scientific Sessions 2015, researchers from the Perelman School of Medicine at the University of Pennsylvania will present findings from their analysis of the chronic renal insufficiently cohort study to evaluate risk markers for adverse cardiac events in patients with CKD. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 8, 2015 Category: Global & Universal Source Type: news

Gut microbiota changes in diabetic kidney disease contribute to chronic inflammation and vascular complications
Among patients with type 2 diabetes and advanced chronic kidney disease (CKD), a shift in gut microbiota diversity in combination with elevated plasma zonulin levels substantially impacts the degree of chronic inflammation and endothelial dysfunction. Zonulin could be a potential future target to control inflammatory immune responses, according to a new study. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 6, 2015 Category: Science Source Type: news

Blood test can predict kidney disease 5 years before damage starts
Stephen FellerCHICAGO, Nov. 6 (UPI) -- Testing blood for soluble urokinase-type plasminogen activator receptor can predict risk for developing chronic kidney disease 5 years before it causes harm. (Source: Health News - UPI.com)
Source: Health News - UPI.com - November 6, 2015 Category: Consumer Health News Source Type: news

Early warning found for chronic kidney disease
A simple blood test for the suPAR protein can predict a person's chances of developing chronic kidney disease five years before symptoms emerge, thus doing for kidney disease what cholesterol has done for cardiovascular disease, new research shows. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 5, 2015 Category: Science Source Type: news

Early Warning Sign for Kidney Disease Identified in Study
Researchers say blood test can predict risk up to five years before damage begins Source: HealthDay Related MedlinePlus Pages: Chronic Kidney Disease, Laboratory Tests (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - November 5, 2015 Category: Consumer Health News Source Type: news

When Initiating Dialysis, Can eGFR Stand Alone?When Initiating Dialysis, Can eGFR Stand Alone?
New Japanese guidelines raise questions about whether creatinine levels are sufficient to determine the need for dialysis in chronic kidney disease, says Dr Jeffrey Berns. Medscape Nephrology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 28, 2015 Category: Consumer Health News Tags: Nephrology Commentary Source Type: news

NICE approves new drug for chronic kidney disease
For the first time, a treatment will be available on the NHS in England and Wales that can delay the development of autosomal dominant polycystic kidney disease (ADPKD). (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - October 28, 2015 Category: Nursing Source Type: news

Chronic Heartburn Drugs Tied to Higher Risk of Kidney Disease
But studies weren't designed to prove proton pump inhibitors are responsible for the increase Source: HealthDay Related MedlinePlus Pages: Chronic Kidney Disease, Heartburn (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - October 27, 2015 Category: Consumer Health News Source Type: news

Revascularization in Patients With Multivessel CAD and CKDRevascularization in Patients With Multivessel CAD and CKD
Find out more about the treatment paradox for patients with chronic kidney disease who need coronary revascularization. Journal of the American College of Cardiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 26, 2015 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

DR ELLIE CANNON: I'm losing sleep over back ache  
The Mail on Sunday's GP answers readers' questions on ankylosing spondylitis and chronic kidney disease, and praises Oprah Winfrey for her decision to use WeightWatchers. (Source: the Mail online | Health)
Source: the Mail online | Health - October 26, 2015 Category: Consumer Health News Source Type: news

Kidney Patients without Online Access Face Additional Burden
Blacks and the poor are often 'left behind,' researcher says Source: HealthDay Related MedlinePlus Pages: Chronic Kidney Disease, Health Disparities (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - October 22, 2015 Category: Consumer Health News Source Type: news

Peninsula biotech eyes drug launch after winning FDA approval
Relypsa Inc. won its first drug approval Wednesday as the Food and Drug Administration approved its treatment for potentially fatal levels of potassium in chronic kidney disease patients. The drug, for which the Redwood City company (NASDAQ: RLYP) hadn't announced a price as of late Wednesday afternoon, will carry a "boxed warning" because it could cause other oral drugs to be less effective. A Relypsa spokesman said the company would discuss pricing on a conference call Thursday morning. Pricing… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - October 22, 2015 Category: Biotechnology Authors: Ron Leuty Source Type: news

Investigators create complex kidney structures from human stem cells derived from adults
A highly efficient method has been developed for making kidney structures from stem cells that are derived from skin taken from patients. The kidney structures formed could be used to study abnormalities of kidney development, chronic kidney disease, the effects of toxic drugs, and be incorporated into bioengineered devices to treat patients with acute and chronic kidney injury, say scientists. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 17, 2015 Category: Science Source Type: news