Congenital Diseases of the Kidneys: Prognosis and Treatments
Chronic kidney disease (CKD) is a growing public health problem with a huge economic burden on society. In children, congenital anomalies of the kidneys and urinary tract (CAKUT) are the most common cause for CKD. Normal development of the kidneys and urinary tract progresses through a complex series of events and requires the expression of key transcription factors to occur with precision in the fetus. It is now known that many genetic defects can lead to CAKUT. Most CAKUT can be identified prenatally with antenatal ultrasonography, and in cases of severe oligohydramnios, prenatal options such as vesicoamniotic shunting a...
Source: NeoReviews recent issues - June 1, 2017 Category: Pediatrics Authors: Feldenberg, R., Beck, A. Tags: Pediatric Drug Labeling Update Articles Source Type: news

What Adult Problems Can Start with Fetal Undernutrition?
Discussion Developmental origins of health and disease (DOHaD) is a scientific hypothesis that proposes that fetal nutrition has permanent effects on growth, metabolism, and structure. These changes, or biological programming, are felt to occur at critical periods in fetal development “…when developmental changes in the organism towards increasing complexity, greater plasticity, and more efficient functioning occurs rapidly and may be most easily modified either in favorable or unfavorable directions.” Fetal undernutrition has been studied more than overnutrition, and various nutritional components (prot...
Source: PediatricEducation.org - May 29, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Akebia doses first patient in Phase II trial of vadadustat to treat DD-CKD
US-based biopharmaceutical firm Akebia Therapeutics has started dosing patients in its Phase II FO2RWARD clinical trial of vadadustat for the treatment of patients with dialysis-dependent chronic kidney disease (DD-CKD). (Source: Drug Development Technology)
Source: Drug Development Technology - May 25, 2017 Category: Pharmaceuticals Source Type: news

For Parents Of Kids With Pre-existing Conditions, Trumpcare Is Terrifying
Megan, 36, still had 16 weeks left in her pregnancy when she gave birth to her second child four years ago. Her daughter, Ellie, teetered on the edge of survival and weighed less than a pound. She spent the first four months of her life hooked up to tubes in the NICU. At the time, Megan—who asked that only her first name be used—had health insurance though Obamacare. Ellie also qualified for secondary Medicaid coverage. The couple still relies on that combination to cover her ongoing health complications: Chronic lung disease, which requires her to be on oxygen; intestinal complications that require a special f...
Source: Healthy Living - The Huffington Post - May 5, 2017 Category: Consumer Health News Source Type: news

TECOS: Sitagliptin Safe in CKD Patients (CME/CE)
(MedPage Today) -- Sub-analysis in patients with chronic kidney disease and T2DM raised no safety concerns (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - April 26, 2017 Category: Cardiology Source Type: news

One in 10 People Worldwide Have Chronic Kidney Disease One in 10 People Worldwide Have Chronic Kidney Disease
Detailed information from 125 countries shows widespread gaps in care, and despite 10% of people in the world having kidney disease, many high-income countries report it is not a priority.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 21, 2017 Category: Consumer Health News Tags: Nephrology News Source Type: news

New global report highlights burden and neglect of kidney disease worldwide
(International Society of Nephrology) Despite one in 10 people worldwide having chronic kidney disease, a new global report -- The Global Kidney Health Atlas -- presented at this week's World Congress of Nephrology in Mexico City and compiled by the International Society of Nephrology (ISN) and kidney health experts worldwide and published in JAMA -- highlights the huge gaps in kidney disease care and prevention in both developed and developing countries, with many countries not prioritizing kidney health. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 21, 2017 Category: Global & Universal Source Type: news

Value of Osteoporosis Drugs Uncertain in Patients With CKD Value of Osteoporosis Drugs Uncertain in Patients With CKD
The benefits and harms of drugs used to treat osteoporosis in patients with chronic kidney disease are still uncertain, according to a systemic review and meta-analysis of the literature.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 18, 2017 Category: Consumer Health News Tags: Orthopaedics News Source Type: news

Pro: Heat stress as a potential etiology of Mesoamerican and Sri Lankan nephropathy: a late night consult with Sherlock Holmes - Johnson RJ.
Epidemics of chronic kidney disease are now recognized in Central America, Mexico, India and Sri Lanka, and there is also some evidence that similar epidemics may be occurring in the USA, Thailand and elsewhere. A common denominator for each location is ma... (Source: SafetyLit)
Source: SafetyLit - April 17, 2017 Category: Global & Universal Tags: Commentary Source Type: news

Detecting diabetic kidney disease before it really sets in
The damage done by chronic kidney disease is irreversible: once the illness has taken hold, the organ can't be healed. Patients' prospects and quality of life would be much improved if the condition could be spotted sooner. An EU-funded project has developed a biomarker test to pick up very early signs of diabetic kidney disease, and identified possible improvements in the approach to therapy. (Source: EUROPA - Research Information Centre)
Source: EUROPA - Research Information Centre - April 13, 2017 Category: Research Source Type: news

Health Tip: Should You Be Tested for Kidney Disease?
-- Chronic kidney disease may not have obvious symptoms, so it's important to know if you're at risk. The U.S. Centers for Disease Control and Prevention says risk factors include: Having diabetes. Having high blood pressure. Having heart... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 11, 2017 Category: Journals (General) Source Type: news

Osteoporosis Drugs Have Uncertain Benefit in Chronic Kidney Disease (FREE)
By Joe Elia Edited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD The benefits of osteoporosis drugs for preserving bone health in patients with chronic kidney disease are uncertain, according to an Annals … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - April 11, 2017 Category: Primary Care Source Type: news

CKD: Low Urine Ammonium Excretion Linked to Death, ESRD CKD: Low Urine Ammonium Excretion Linked to Death, ESRD
Patients with chronic kidney disease who had low urine ammonium excretion were at greater risk for kidney disease progression or death, a new study has found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 11, 2017 Category: Consumer Health News Tags: Nephrology News Source Type: news

CAC Predicts CVD Risk in Chronic Kidney Disease CAC Predicts CVD Risk in Chronic Kidney Disease
In a rare look at CAC risk assessment in this special population, the predictive value of more conventional risk factors wasn't nearly as strong."The calcium score really blows them away."Heartwire from Medscape (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 30, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

Impaired Vascular Function and Exercise Intolerance in CKD Impaired Vascular Function and Exercise Intolerance in CKD
Gain a better understanding of how vascular dysfunction may impact exercise intolerance in patients with chronic kidney disease.Nephrology Dialysis Transplantation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 24, 2017 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

Proteon CEO: New trial could be a path to market
After Proteon Therapeutics Inc.'s chronic kidney disease treatment failed a late clinical trial, the company is forging forward with a new plan that could take the drug to market. The Waltham, Mass.-based company's treatment, vonapanitase, was originally developed by Kansas City entrepreneur Nick Franano. It's intended to help maintain blood flow through an arteriovenous fistula (AVF), a connection between an artery and a vein, used for patients on dialysis. "What we're tr ying to do is not just… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - March 17, 2017 Category: Pharmaceuticals Authors: Elise Reuter Source Type: news

Nigeria: Ignorance Kills Kidney Disorder Patients
[Vanguard] March 9, 2017 was World Kidney Day, a day set aside for global awareness on the importance of kidney. The day was part of the campaign to urgently reduce the risk factors for chronic kidney disease, CKD, in the world. This year's theme was "Kidney Disease& Obesity". (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - March 12, 2017 Category: African Health Source Type: news

Cost of Kidney Dialysis in Sub-Saharan Africa Cost of Kidney Dialysis in Sub-Saharan Africa
Up to one-fourth of adults in sub-Saharan Africa suffer from chronic kidney disease and only a small fraction ever reach a dialysis treatment center, a new study finds.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - March 11, 2017 Category: Transplant Surgery Tags: Nephrology News Source Type: news

Cost of kidney dialysis poses ethical dilemma in sub-Saharan Africa
(Reuters Health) - Up to one-fourth of adults in sub-Saharan Africa suffer from chronic kidney disease and only a small fraction ever reach a dialysis treatment center, a new study finds. (Source: Reuters: Health)
Source: Reuters: Health - March 9, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Diet changes key to manage 'silent killer' of chronic kidney disease
Chronic kidney disease patient makes drastic changes to her diet to maintain health (Source: CBC | Health)
Source: CBC | Health - March 9, 2017 Category: Consumer Health News Tags: News/Health Source Type: news

Clinical: Understanding chronic kidney disease
How can nurses help patients to understand and manage this disease?You must sign in to continue reading this articleHide related content:  Show related contentread more (Source: Nursing in Practice)
Source: Nursing in Practice - March 9, 2017 Category: Nursing Authors: bkennedy Tags: Diabetes Editor ' s pick Featured Articles Source Type: news

Reata initiates Phase II/III trial of bard to treat Alport Syndrome-caused CDK
US-based clinical-stage biopharmaceutical company Reata Pharmaceuticals has initiated patient screening in a Phase II/III trial of bardoxolone methyl (bard) for the treatment of patients with chronic kidney disease (CKD) caused by Alport syndrome. (Source: Drug Development Technology)
Source: Drug Development Technology - February 27, 2017 Category: Pharmaceuticals Source Type: news

PPIs May Increase Risk for Chronic, Silent Kidney Damage PPIs May Increase Risk for Chronic, Silent Kidney Damage
Most patients who develop chronic kidney disease while taking proton pump inhibitors do not experience acute kidney problems first, a new study showed.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - February 24, 2017 Category: Gastroenterology Tags: Nephrology News Source Type: news

Children's Mercy gets green light to expand kidney disease study
A massive, national chronic kidney disease study gained funding to study risk factors for children shortly after their diagnosis. More than a decade underway, the CKiD study was spearheaded by Children's Mercy and the Children's Hospital of Philadelphia in 2003, in response to a request for applications by the National Institutes of Health. Since its inception, the study has brought together 54 different centers across the U.S. and followed more than 900 pediatric patients to determine what causes… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 23, 2017 Category: Pharmaceuticals Authors: Elise Reuter Source Type: news

CABG vs. PCI in Patients With DM, Multivessel CAD, and CKD CABG vs. PCI in Patients With DM, Multivessel CAD, and CKD
What's the optimal method of coronary revascularization among patients with diabetes mellitus and multivessel CAD complicated by chronic kidney disease?European Heart Journal (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - February 20, 2017 Category: Surgery Tags: Cardiology Journal Article Source Type: news

Cutting Salt a Health Boost for Kidney Patients
Blood pressure and fluid retention improve in those counseled by dietitians, small study shows Source: HealthDay Related MedlinePlus Pages: Chronic Kidney Disease, Sodium (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - February 17, 2017 Category: Consumer Health News Source Type: news

How to improve the 'health literacy' of parents caring for kids with chronic kidney disease
A study out of Sick Kids underscores the value of reinforcing training to parents after their child is diagnosed with chronic kidney illness. (Source: CBC | Health)
Source: CBC | Health - February 17, 2017 Category: Consumer Health News Tags: News/Health Source Type: news

Catheter Ablation of AF in Patients With CKD Catheter Ablation of AF in Patients With CKD
Do patients with chronic kidney disease who undergo catheter ablation for atrial fibrillation suffer more postprocedural complications or worse outcomes than those with normal kidney function?Journal of Cardiovascular Electrophysiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 17, 2017 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Study finds genetic links with kidney injury
Cases of acute kidney injury (AKI) in hospitals are on the rise but treatments are elusive. To deepen understanding of the condition, which can lead to chronic kidney disease or death, a Yale-led research team conducted the largest study of genes associated with AKI to date. (Source: Yale Science and Health News)
Source: Yale Science and Health News - February 16, 2017 Category: Universities & Medical Training Tags: Yale News Source Type: news

Reducing Cardiovascular Mortality in Kidney Disease: Time to Focus on Heart Failure? Reducing Cardiovascular Mortality in Kidney Disease: Time to Focus on Heart Failure?
Dr Bansal discusses several key clinical trials examining cardiovascular disease risk in patients with chronic kidney disease.Medscape Nephrology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 10, 2017 Category: Consumer Health News Tags: Nephrology Article Source Type: news

US FDA approves Amgen ’s Parsabiv to treat HPT in adult patients
The US Food and Drug Administration (FDA) has approved Amgen ’s Parsabiv (etelcalcetide) to treat secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on haemodialysis. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - February 9, 2017 Category: Pharmaceuticals Source Type: news

FDA approves Amgen drug for secondary hyperparathyroidism
(Reuters) - The U.S. Food and Drug Administration has approved Amgen Inc's treatment for secondary hyperparathyroidism in adult patients with chronic kidney disease undergoing dialysis, the U.S. biotech company said on Tuesday. (Source: Reuters: Health)
Source: Reuters: Health - February 8, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

FDA Approves Amgen's Parsabiv ™ (Etelcalcetide), First New Treatment In More Than A Decade For Secondary Hyperparathyroidism In Adult Patients On Hemodialysis
Intravenous Administration Puts Delivery in Hands of Healthcare Provider THOUSAND OAKS, Calif., Feb. 7, 2017 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that the U.S. Food and Drug Administration (FDA) has approved Parsabiv™ (etelcalcetide) for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis. Parsabiv is the first therapy approved for this condition in 12 years and the only calcimimetic that can be administered intravenously by the dialysis health care team three times a week at the end of the hemodialysis session. To view ...
Source: Amgen News Release - February 8, 2017 Category: Pharmaceuticals Tags: Uncategorized Source Type: news

Mineralocorticoid Antagonists in Chronic Kidney Disease Mineralocorticoid Antagonists in Chronic Kidney Disease
What role do mineralocorticoid receptor antagonists have in the treatment paradigm of CKD?Current Opinion in Nephrology and Hypertension (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 6, 2017 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

Donor dilemma
When her daughter, Thalya, was diagnosed with chronic kidney disease, Chantal Onelien's initial reaction was shock. But, as Adam Harris reports, it was only the beginning of a long and difficult fight. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - February 6, 2017 Category: Consumer Health News Source Type: news

Skin sodium content linked to heart problems in patients with kidney disease
Elevated sodium content in the skin correlates closely with left ventricular hypertrophy in patients with chronic kidney disease, report researchers. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 3, 2017 Category: Science Source Type: news

IV contrast for CT is not associated with increased risk of acute kidney injury
Intravenous contrast media (typically iohexol or iodixanol) used in computed tomography (CT) does not appear to be associated with chronic kidney disease, dialysis, kidney transplant or acute kidney injury, despite long-held fears to the contrary. The results of the largest controlled study of acute kidney injury following contrast media administration in the emergency department were just published. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 26, 2017 Category: Science Source Type: news

IV contrast for CT is not associated with increased risk of acute kidney injury
(American College of Emergency Physicians) Intravenous contrast media (typically iohexol or iodixanol) used in computed tomography (CT) does not appear to be associated with chronic kidney disease, dialysis, kidney transplant or acute kidney injury, despite long-held fears to the contrary. The results of the largest controlled study of acute kidney injury following contrast media administration in the emergency department were published online yesterday in Annals of Emergency Medicine ('Risk of Acute Kidney Injury Following Intravenous Contrast Media Administration'). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 26, 2017 Category: Global & Universal Source Type: news

Ferric Citrate Improves Iron-Deficiency Anemia in Chronic Kidney Disease Ferric Citrate Improves Iron-Deficiency Anemia in Chronic Kidney Disease
Oral treatment with ferric citrate improves iron-deficiency anemia in patients with non-dialysis-dependent chronic kidney disease (NDD-CKD), according to a randomized controlled trial.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - January 20, 2017 Category: Intensive Care Tags: Family Medicine/Primary Care News Source Type: news

Statin Use Associated With Benefits in Early-Stage Kidney Disease Statin Use Associated With Benefits in Early-Stage Kidney Disease
Patients with early-stage chronic kidney disease (CKD) who take statins have reduced mortality and a slower decline in kidney function, though this is not true for patients with more advanced disease, new findings show.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 20, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

CKD care has improved but GPs should conduct more urine tests, report says
GPs have helped cut the need for dialysis among patients with chronic kidney disease (CKD) through earlier diagnosis over the last decade, but greater use of annual urine testing and accurate read coding could boost progress further, according to a clinical audit. (Source: GP Online News)
Source: GP Online News - January 18, 2017 Category: Primary Care Tags: Renal disorders Source Type: news

PAs are Altering the Course of Chronic Kidney Disease
Certified PAs and other healthcare providers can follow this simple assessment protocol to help with early detection of chronic kidney disease. (Source: Physicians Practice)
Source: Physicians Practice - January 17, 2017 Category: Practice Management Authors: Kendra Thomsen, PA-C Tags: Blog CME Staff Tools Source Type: news

Kidney disease patients have higher out-of-pocket costs than stroke and cancer patients
(Loyola University Health System) Patients who have chronic kidney disease but are not on dialysis have higher out-of-pocket healthcare expenses than even stroke and cancer patients, according to a Loyola University Chicago study published in BMC Nephrology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 17, 2017 Category: Cancer & Oncology Source Type: news

The Challenges of Treating Cancer Patients on Hemodialysis, or With Chronic Kidney Disease
It is challenging to diagnose, manage, and treat patients who have kidney disease in addition to cancer. Second to cardiovascular disease, cancer represents a major cause of mortality and morbidity in the kidney disease population. (Source: CancerNetwork)
Source: CancerNetwork - January 15, 2017 Category: Cancer & Oncology Authors: Charbel C. Khoury, MD David J. R. Steele, MD Tags: Oncology Journal Source Type: news

Trial finds oral iron drug safe, effective for treating anemia in kidney disease patients
In a phase 3 trial of patients with chronic kidney disease, 52.1% of patients receiving oral ferric citrate experienced a significant boost in hemoglobin levels (a reflection of red blood cell counts) compared with 19.1% of patients receiving placebo. A treatment effect was seen as early as 1-2 weeks after the start of treatment, and the response was durable. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 13, 2017 Category: Science Source Type: news

Having a health check could save your life
Regular health checks – which are commissioned by councils as part of their public health duties - are saving lives across the country by identifying early signs of potentially life-threatening conditions. More new cases of diabetes, hypertension, and chronic kidney disease were identified among attendees than a matche d group of non-attendees. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 11, 2017 Category: Consumer Health News Source Type: news

Study Results Published in the Journal of the American Medical Association Show Amgen's Parsabiv ™ (Etelcalcetide) Significantly Reduced Serum Parathyroid Hormone in Adults With Secondary Hyperparathyroidism on Hemodialysis
THOUSAND OAKS, Calif., Jan. 10, 2017 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced the Journal of the American Medical Association (JAMA) publication of findings from three Phase 3 studies of Parsabiv™ (etelcalcetide), an investigational intravenous calcimimetic agent in the U.S. The studies evaluated Parsabiv in more than 1,700 adults with secondary hyperparathyroidism (sHPT) on hemodialysis and showed that the drug produced statistically significant and clinically meaningful reductions in serum parathyroid hormone (PTH) levels, a key marker of sHPT. sHPT is a chronic and serious condition that is often p...
Source: Amgen News Release - January 10, 2017 Category: Pharmaceuticals Tags: Uncategorized Source Type: news

' Goldilocks' drug prevents chronic kidney disease in primates
A research team has developed a way to avoid ischemia/reperfusion injury of the kidney with a new monoclonal antibody that binds its target receptor in a way that is'just right.'(Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 10, 2017 Category: Science Source Type: news