Molecules, Vol. 29, Pages 767: Establishment and Validation of a Transdermal Drug Delivery System for the Anti-Depressant Drug Citalopram Hydrobromide
Yan-qiang Liu
To enhance the bioavailability and antihypertensive effect of the anti-depressant drug citalopram hydrobromide (CTH) we developed a sustained-release transdermal delivery system containing CTH. A transdermal diffusion meter was first used to determine the optimal formulation of the CTH transdermal drug delivery system (TDDS). Then, based on the determined formulation, a sustained-release patch was prepared; its physical characteristics, including quality, stickiness, and appearance, were evaluated, and its pharmacokinetics and irritation to the skin were evaluated by applying it to rabbits and rats. The o...
Source: Molecules - February 7, 2024 Category: Chemistry Authors: Yi-yang Sun Ya-jing Ni Run-jia Wang Zi-cheng Qin Zhao Liu Li-hui Xiao Yan-qiang Liu Tags: Article Source Type: research
Inhibitory Actions of Antidepressants, Hypnotics, and Anxiolytics on Recombinant Human Acetylcholinesterase Activity
Biol Pharm Bull. 2024;47(1):328-333. doi: 10.1248/bpb.b23-00719.ABSTRACTAlzheimer's disease (AD) is accompanied by behavioral and psychological symptoms of dementia (BPSD), which is often alleviated by treatment with psychotropic drugs, such as antidepressants, hypnotics, and anxiolytics. If these drugs also inhibit acetylcholinesterase (AChE) activity, they may contribute to the suppression of AD progression by increasing brain acetylcholine concentrations. We tested the potential inhibitory effects of 31 antidepressants, 21 hypnotics, and 12 anxiolytics on recombinant human AChE (rhAChE) activity. At a concentration of 1...
Source: Biological and Pharmaceutical Bulletin - January 31, 2024 Category: Drugs & Pharmacology Authors: Keisuke Obara Haruka Mori Suzune Ihara Kento Yoshioka Yoshio Tanaka Source Type: research
Molecules, Vol. 29, Pages 676: Direct Immersion & ndash;Solid Phase Microextraction for Therapeutic Drug Monitoring of Patients with Mood Disorders
This article discusses a new method for monitoring drug concentrations in blood samples from patients with mood disorders. The method uses solid-phase microextraction to extract analytes directly from blood samples. It has been adapted to identify the most commonly used drugs in mood disorders, including amitriptyline, citalopram, fluoxetine, paroxetine, sertraline, trazodone, duloxetine, venlafaxine, lamotrigine, quetiapine, olanzapine, and mirtazapine. The analysis is carried out using high-performance liquid chromatography coupled with mass spectroscopy. The proposed DI-SPME/LC-MS method allows for a simple and quick sc...
Source: Molecules - January 31, 2024 Category: Chemistry Authors: Magdalena Świądro-Piętoń Dominika Dudek Renata Wietecha-Pos łuszny Tags: Article Source Type: research
Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells
In conclusion, hypericin, but not hyperforin or citalopram, is a mitochondrial toxicant at low micromolar concentrations. This mechanism may contribute to the hepatotoxicity occasionally observed in susceptible patients treated with St. John's Wort preparations.PMID:38219807 | DOI:10.1016/j.toxlet.2024.01.008 (Source: Toxicology Letters)
Source: Toxicology Letters - January 14, 2024 Category: Toxicology Authors: Vanessa Fabienne Abegg Miljenko Valentin Panajatovic Riccardo Vincenzo Mancuso Julien Arthur Allard Urs Duthaler Alex Odermatt Stephan Kr ähenbühl Jamal Bouitbir Source Type: research
Cholinesterase inhibitors-associated torsade de pointes/QT prolongation: a real-world pharmacovigilance study
Conclusion: The signals of TdP/QT prolongation related to ChEIs were strong and stable. It is necessary to be vigilant about the TdP/QT prolongation of various ChEIs, especially in elderly women, the initial stage after taking ChEIs, and when ChEIs combining with drugs that could prolong the QT interval. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 11, 2024 Category: Drugs & Pharmacology Source Type: research
Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals
ConclusionThe age-related increase in C/D ratio starts in middle-aged adults and progresses up to more than twofold higher C/D ratio in the oldest old. Sertraline seems to be less prone to age-related changes in C/D ratio than the other antidepressants. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 10, 2024 Category: Drugs & Pharmacology Source Type: research
Perinatal Depression: A Guide to Detection and Management in Primary Care
Conclusions:
These clinically relevant data can support the delivery of high-quality care by PCCs. Risks and benefits of PD treatments and the consequences of untreated PD should be discussed with patients to support informed decision making. (Source: Journal of the American Board of Family Medicine)
Source: Journal of the American Board of Family Medicine - January 5, 2024 Category: Primary Care Authors: Dama, M. H., Van Lieshout, R. J. Tags: Clinical Review Source Type: research
Citalopram/paroxetine
(Source: Reactions Weekly)
Source: Reactions Weekly - January 1, 2024 Category: Drugs & Pharmacology Source Type: research
Adverse drug events associated with nortriptyline compared with paroxetine and alternative medications in an older adult population: a retrospective cohort study in Southern California
Conclusions
Compared with therapeutic alternatives, nortriptyline was found to represent a lower risk for falls, fractures and syncope, versus comparator medications, except for a few instances that had equivalent risk. The risk for these adverse events from paroxetine was comparable to the alternative medications. (Source: BMJ Open)
Source: BMJ Open - December 28, 2023 Category: General Medicine Authors: George, M. M., Deamer, R. L., Do, D. Tags: Open access, Geriatric medicine Source Type: research
Drug-induced QT prolongation and torsade de pointes: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System database
Conclusion: Our study provided a real-world overview of QT prolongation and TdP to drugs, and the presentation of the potential culprit-drug list, the proportion of reports, the detection results of ADR signals, and the distribution characteristics of ADR signals may help understand the safety profile of drugs and optimize clinical practice. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 21, 2023 Category: Drugs & Pharmacology Source Type: research
Changes in prescribing of psychotropic vs some physical health medication in primary care through the COVID-19 pandemic in England: a national-level survey
ConclusionsThe increase in anxiolytic/hypnotic prescribing above trend links to pandemic effects on anxiety/worry. If anything, there was a slight fall in prescribing of the main antidepressants prescribed, which given prevailing circumstances at the time, suggests that access to services may have restricted access to timely assessment. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - December 21, 2023 Category: Pharmaceuticals Source Type: research
Efficacy of pharmacotherapies for bulimia nervosa: a systematic review and meta-analysis
CONCLUSIONS: This meta-analysis indicates that most pharmacotherapies decreased the frequency of binge-eating and vomiting episodes, body weight, and depressive symptoms in BN patients, but the efficacy was not significant. In each drug the efficacy is different, treating different aspects, different symptoms to improve the clinical performance of bulimia nervosa.PMID:38042827 | DOI:10.1186/s40360-023-00713-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - December 2, 2023 Category: Drugs & Pharmacology Authors: Sijie Yu Yuhan Zhang Chongkai Shen Fei Shao Source Type: research
Efficacy of pharmacotherapies for bulimia nervosa: a systematic review and meta-analysis
CONCLUSIONS: This meta-analysis indicates that most pharmacotherapies decreased the frequency of binge-eating and vomiting episodes, body weight, and depressive symptoms in BN patients, but the efficacy was not significant. In each drug the efficacy is different, treating different aspects, different symptoms to improve the clinical performance of bulimia nervosa.PMID:38042827 | PMC:PMC10693702 | DOI:10.1186/s40360-023-00713-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - December 2, 2023 Category: Drugs & Pharmacology Authors: Sijie Yu Yuhan Zhang Chongkai Shen Fei Shao Source Type: research
