Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells

In conclusion, hypericin, but not hyperforin or citalopram, is a mitochondrial toxicant at low micromolar concentrations. This mechanism may contribute to the hepatotoxicity occasionally observed in susceptible patients treated with St. John's Wort preparations.PMID:38219807 | DOI:10.1016/j.toxlet.2024.01.008

Source: Toxicology Letters - January 14, 2024 Category: Toxicology Authors: Vanessa Fabienne Abegg Miljenko Valentin Panajatovic Riccardo Vincenzo Mancuso Julien Arthur Allard Urs Duthaler Alex Odermatt Stephan Kr ähenbühl Jamal Bouitbir Source Type: research