Molecules, Vol. 29, Pages 767: Establishment and Validation of a Transdermal Drug Delivery System for the Anti-Depressant Drug Citalopram Hydrobromide
Molecules, Vol. 29, Pages 767: Establishment and Validation of a Transdermal Drug Delivery System for the Anti-Depressant Drug Citalopram Hydrobromide
Molecules doi: 10.3390/molecules29040767
Authors:
Yi-yang Sun
Ya-jing Ni
Run-jia Wang
Zi-cheng Qin
Zhao Liu
Li-hui Xiao
Yan-qiang Liu
To enhance the bioavailability and antihypertensive effect of the anti-depressant drug citalopram hydrobromide (CTH) we developed a sustained-release transdermal delivery system containing CTH. A transdermal diffusion meter was first used to determine the optimal formulation of the CTH transdermal drug delivery system (TDDS). Then, based on the determined formulation, a sustained-release patch was prepared; its physical characteristics, including quality, stickiness, and appearance, were evaluated, and its pharmacokinetics and irritation to the skin were evaluated by applying it to rabbits and rats. The optimal formulation of the CTH TDDS was 49.2% hydroxypropyl methyl cellulose K100M, 32.8% polyvinylpyrrolidone K30, 16% oleic acid-azone, and 2% polyacrylic acid resin II. The system continuously released an effective dose of CTH for 24 h and significantly enhanced its bioavailability, with a higher area under the curve, good stability, and no skin irritation. The developed CTH TDDS possessed a sustained-release effect and good characteristics and pharmacokinetics; therefore, it has the potential for clinical application as an antidepressant.
Source: Molecules - Category: Chemistry Authors: Yi-yang Sun Ya-jing Ni Run-jia Wang Zi-cheng Qin Zhao Liu Li-hui Xiao Yan-qiang Liu Tags: Article Source Type: research