Pharmacotherapy for generalized anxiety disorder in adult and pediatric patients: an evidence-based treatment review.
Authors: Strawn JR, Geracioti L, Rajdev N, Clemenza K, Levine A
Abstract
INTRODUCTION: Generalized anxiety disorder (GAD) often begins during adolescence or early adulthood and persists throughout the lifespan. Randomized controlled trials support the efficacy of selective serotonin and selective serotonin norepinephrine reuptake inhibitors (SSRIs and SNRIs, respectively), as well as benzodiazepines, azapirones, anti-adrenergic medications, melatonin analogs, second-generation antipsychotics, kava, and lavender oil in GAD. However, psychopharmacologic treatment selection requires clinicians to consider mul...
Source: Expert Opinion on Pharmacotherapy - August 1, 2018 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Dopamine and serotonin metabolism associated with morphine reward and its inhibition with buspirone: A study in the rat striatum
Publication date: July 2018Source: Pharmacology Biochemistry and Behavior, Volume 170Author(s): Darakhshan Jabeen Haleem, Shazia Nawaz, Tabinda SalmanAbstractAdaptations within the nucleus accumbens (NAc) and caudate nucleus (CN) dopamine neurotransmission are involved in behavioral sensitization and enhanced incentive motivation towards drug paired stimuli which lead to drug addiction. Serotonin (5-hydroxytryptamine; 5-HT) can modulate dopamine neurotransmission to reduce rewarding effects of drugs of abuse. A recent study from our laboratory shows that rewarding effects of morphine are inhibited in rats co-treated with b...
Source: Pharmacology Biochemistry and Behavior - July 11, 2018 Category: Biochemistry Source Type: research
Leaves of Spondias mombin L. a traditional anxiolytic and antidepressant: Pharmacological evaluation on zebrafish (Danio rerio)
ConclusionsOur results suggest that the acute administration of the HELSm in the scototaxis and NTDT tests in a zebrafish model (Danio rerio) produced an anxiolytic and antidepressant effects, devoid of hypnotic and sedative actions by immersion, and this action was improved when administered by oral via. Possibly, the presence of isoquercitrin in the leaves of Spondias mombin participates in the anxiolytic and antidepressant effects.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Dopamine and serotonin metabolism associated with morphine reward and its inhibition with buspirone: A study in the rat striatum
Publication date: July 2018Source: Pharmacology Biochemistry and Behavior, Volume 170Author(s): Darakhshan Jabeen Haleem, Shazia Nawaz, Tabinda SalmanAbstractAdaptations within the nucleus accumbens (NAc) and caudate nucleus (CN) dopamine neurotransmission are involved in behavioral sensitization and enhanced incentive motivation towards drug paired stimuli which lead to drug addiction. Serotonin (5-hydroxytryptamine; 5-HT) can modulate dopamine neurotransmission to reduce rewarding effects of drugs of abuse. A recent study from our laboratory shows that rewarding effects of morphine are inhibited in rats co-treated with b...
Source: Pharmacology Biochemistry and Behavior - July 5, 2018 Category: Biochemistry Source Type: research
Effects of lorcaserin and buspirone, administered alone and as a mixture, on cocaine self-administration in male and female rhesus monkeys.
Cocaine use disorder is a serious public health issue for which there is no effective pharmacotherapy. One strategy to speed development of medications for cocaine use disorder is to repurpose drugs already approved for use in humans based on their ability to interact with targets known to be important for addiction. Two such drugs, lorcaserin (Belviq; a drug with serotonin [5-HT]2C receptor agonist properties) and buspirone (Buspar; a drug with 5-HT1A receptor partial agonist and dopamine D3/D4 receptor antagonist properties) can produce modest decreases in cocaine self-administration in rhesus monkeys. The current study ...
Source: Experimental and Clinical Psychopharmacology - June 28, 2018 Category: Psychiatry & Psychology Source Type: research
Evaluation of the Impact of a Multimodel Intervention on Prescribing Patterns of Sedative-Hypnotics in a Behavioral Health System.
Conclusions: Implementation of a multimodal intervention led to a significant decrease in rates of chronic sedative-hypnotic prescriptions in a large behavioral health system.
PMID: 29873949 [PubMed - in process] (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - June 7, 2018 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Buspirone Treatment of Anxiety in an Adolescent Female with Avoidant/Restrictive Food Intake Disorder
Journal of Child and Adolescent Psychopharmacology, Ahead of Print. (Source: Journal of Child and Adolescent Psychopharmacology)
Source: Journal of Child and Adolescent Psychopharmacology - May 29, 2018 Category: Pediatrics Authors: Nnenna Kalaya Okereke Source Type: research
Dopamine and serotonin metabolism associated with morphine reward and its inhibition with buspirone: A study in the rat striatum
Publication date: July 2018 Source:Pharmacology Biochemistry and Behavior, Volume 170 Author(s): Darakhshan Jabeen Haleem, Shazia Nawaz, Tabinda Salman Adaptations within the nucleus accumbens (NAc) and caudate nucleus (CN) dopamine neurotransmission are involved in behavioral sensitization and enhanced incentive motivation towards drug paired stimuli which lead to drug addiction. Serotonin (5-hydroxytryptamine; 5-HT) can modulate dopamine neurotransmission to reduce rewarding effects of drugs of abuse. A recent study from our laboratory shows that rewarding effects of morphine are inhibited in rats co-treated with bu...
Source: Pharmacology Biochemistry and Behavior - May 29, 2018 Category: Biochemistry Source Type: research
Substance-induced anxiety disorder after one dose of 3,4-methylenedioxymethamphetamine: a case report
ConclusionsOur patient ’s case not only demonstrates a rare presentation of 3,4-methylenedioxymethamphetamine-induced anxiety disorder but also provides support for the use of the Primary Care Behavioral Health model to deliver individualized, timely mental health care in a primary care setting. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 25, 2018 Category: General Medicine Source Type: research
Convergence on reduced stress behavior in the Mexican Blind Cavefish.
Abstract
Responding appropriately to stress is essential for survival, yet in pathological states, these responses can develop into debilitating conditions such as post-traumatic stress disorder and generalized anxiety. While genetic models have provided insight into the neurochemical and neuroanatomical pathways that underlie stress, little is known about how evolutionary processes and naturally occurring variation contribute to the diverse responses to stressful stimuli observed in the animal kingdom. The Mexican cavefish is a powerful system to address how altered genetic and neuronal systems can give r...
Source: Developmental Biology - May 24, 2018 Category: Biology Authors: Chin JSR, Gassant CE, Amaral PM, Lloyd E, Stahl BA, Jaggard JB, Keene AC, Duboue ER Tags: Dev Biol Source Type: research
Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model.
Abstract
The current study investigates the cytotoxicity mechanism of common drugs with piperazine ring such as cetirizine, olanzapine and buspirone on human lymphocytes. The viability of lymphocytes, reactive oxygen species (ROS) formation, mitochondrial membrane potential (MMP) collapse, lysosomal integrity, content of glutathione and lipid peroxidation were determined. Buspirone and cetirizine showed more toxicity than olanzapine on human lymphocytes with an IC50 value of 200 μg/ml, after 6 h of incubation. Significant ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of g...
Source: Current Clinical Pharmacology - May 15, 2018 Category: Drugs & Pharmacology Authors: Pourahmad J, Salimi A, Razian M Tags: Curr Clin Pharmacol Source Type: research
Facilitation of Locomotor Spinal Networks Activity by Buspirone after a Complete Spinal Cord Lesion in Mice
Journal of Neurotrauma, Ahead of Print. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - May 7, 2018 Category: Neurology Authors: Renaud Jeffrey-Gauthier Nicolas Josset Fr édéric Bretzner Hugues Leblond Source Type: research
SSRI-associated bruxism: A systematic review of published case reports
Purpose of review
Antidepressant-associated movement disorders are a well-described phenomenon. However, antidepressant-associated bruxism, jaw pain, or jaw spasm, while reported in dental literature, is less commonly recognized among neurologists. We summarize the clinical features and treatment of antidepressant-associated bruxism and associated jaw pain through a systematic review of case reports.
Recent findings
Antidepressant-associated bruxism may occur in pediatric and adult patients, most commonly among female patients. Patients may develop symptoms with short-term and long-term antidepressant use. Fluoxetine, ser...
Source: Neurology Clinical Practice - April 9, 2018 Category: Neurology Authors: Garrett, A. R., Hawley, J. S. Tags: Review Source Type: research
Audio Recording for Independent Confirmation of Clinical Assessments in Generalized Anxiety Disorder
Conclusion. The audio-digital recording method provides a useful second opinion that can affirm the need for a different treatment intervention in these anxious patients. A second live assessment would have required additional clinic time and added patient burden. The audio-digital recording method is less burdensome than live second opinion assessments and might have utility in both research and clinical practice settings.
Keywords: Generalized anxiety disorder (GAD), anxiolytic medications, anxious symptoms, audio-digital recording, dual review, second opinions
Anxiety symptoms are prevalent in most populations where pe...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Original Research anxiolytic medications anxious symptoms audio-digital recording dual review Generalized anxiety disorder (GAD) second opinions Source Type: research
