The Serotonin 1A (5-HT1A) Receptor as a Pharmacological Target in Depression
We describe how experimental medicine approaches can be helpful in profiling the effects of 5-HT1A receptor modulation on the different clinical domains of depression, and outline some potential neurocognitive models that could be used to test the effects of 5-HT1A biased agonists. (Source: CNS Drugs)
Source: CNS Drugs - June 29, 2023 Category: Neurology Source Type: research
Serotonergic circuit dysregulation underlying autism-related phenotypes in BTBR mouse model of autism
In this study, we assessed 5-HT signals and the functional responsiveness in BTBR mice compared to standard C57BL/6J (B6) control mice to elucidate how 5-HT alterations contribute to behavioral abnormalities in BTBR mice. A lower number of 5-HT neurons in the median raphe, but not in the dorsal raphe, was observed in male and female BTBR mice. Acute systemic injection of buspirone, a 5-HT1A receptor agonist, induced c-Fos in several brain regions in both B6 and BTBR mice; however, blunted c-Fos induction in BTBR mice was documented in the cingulate cortex, basolateral amygdala (BLA), and ventral hippocampus (Hipp). Decreas...
Source: Neuropharmacology - June 10, 2023 Category: Drugs & Pharmacology Authors: Yuki Higuchi Tomoaki Tada Taiga Nakachi Hiroyuki Arakawa Source Type: research
Serotonergic circuit dysregulation underlying autism-related phenotypes in BTBR mouse model of autism
In this study, we assessed 5-HT signals and the functional responsiveness in BTBR mice compared to standard C57BL/6J (B6) control mice to elucidate how 5-HT alterations contribute to behavioral abnormalities in BTBR mice. A lower number of 5-HT neurons in the median raphe, but not in the dorsal raphe, was observed in male and female BTBR mice. Acute systemic injection of buspirone, a 5-HT1A receptor agonist, induced c-Fos in several brain regions in both B6 and BTBR mice; however, blunted c-Fos induction in BTBR mice was documented in the cingulate cortex, basolateral amygdala (BLA), and ventral hippocampus (Hipp). Decreas...
Source: Neuropharmacology - June 10, 2023 Category: Drugs & Pharmacology Authors: Yuki Higuchi Tomoaki Tada Taiga Nakachi Hiroyuki Arakawa Source Type: research
Serotonergic circuit dysregulation underlying autism-related phenotypes in BTBR mouse model of autism
In this study, we assessed 5-HT signals and the functional responsiveness in BTBR mice compared to standard C57BL/6J (B6) control mice to elucidate how 5-HT alterations contribute to behavioral abnormalities in BTBR mice. A lower number of 5-HT neurons in the median raphe, but not in the dorsal raphe, was observed in male and female BTBR mice. Acute systemic injection of buspirone, a 5-HT1A receptor agonist, induced c-Fos in several brain regions in both B6 and BTBR mice; however, blunted c-Fos induction in BTBR mice was documented in the cingulate cortex, basolateral amygdala (BLA), and ventral hippocampus (Hipp). Decreas...
Source: Neuropharmacology - June 10, 2023 Category: Drugs & Pharmacology Authors: Yuki Higuchi Tomoaki Tada Taiga Nakachi Hiroyuki Arakawa Source Type: research
Buspirone Induces Weight Loss and Normalization of Blood Pressure via the Stimulation of PPAR < em > δ < /em > Dependent Energy Producing Pathway in Spontaneously Hypertensive Rats
CONCLUSION: Buspirone may induce the losses of body weight and abdominal fat weight through the activation of PPARδ dependent catabolic metabolism producing energy, and eventually, the ameliorated lipid metabolism could normalize high blood pressure.PMID:37168052 | PMC:PMC10164918 | DOI:10.1155/2023/7550164 (Source: PPAR Research)
Source: PPAR Research - May 11, 2023 Category: Genetics & Stem Cells Authors: Yong-Jik Lee Hyun-Min Kim Yoo-Na Jang Yoon-Mi Han Hong Seog Seo Tae Woo Jung Ji Hoon Jeong Hyun Jung Lee Kyung Oh Jung Source Type: research
Molecules, Vol. 28, Pages 3680: Anxiolytic-like Effects and Quantitative EEG Profile of Palmitone Induces Responses like Buspirone Rather Than Diazepam as Clinical Drugs
In conclusion, brain electrical activity was associated with the anxiolytic-like effects of palmitone implying a serotoninergic rather than a GABAergic mechanism of action. (Source: Molecules)
Source: Molecules - April 24, 2023 Category: Chemistry Authors: Daniela Onofre-Campos Mar ía Eva González-Trujano Gabriel Fernando Moreno-P érez Fernando Narv áez-González Jos é David González-Gómez Benjam ín Villasana-Salazar David Mart ínez-Vargas Tags: Article Source Type: research
Pharmacological evaluation of the anxiolytic-like effects of an aqueous extract of the Raphanus sativus L. sprouts in mice
Biomed Pharmacother. 2023 Mar 27;162:114579. doi: 10.1016/j.biopha.2023.114579. Online ahead of print.ABSTRACTRaphanus sativus L. (Brassicaceae), commonly known as radish, is consumed worldwide as a vegetable. However, its benefits on mental health are unknown. The aim of this study was to evaluate its anxiolytic-like effects and safety using different experimental models. An aqueous extract of R. sativus sprouts (AERSS) was pharmacologically evaluated by intraperitoneal route (i.p.) at 10, 30, and 100 mg/kg and orally (p.o.) at 500 mg/kg on behavior by using open-field and plus-maze tests. In addition, its acute toxicity ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2023 Category: Drugs & Pharmacology Authors: Laura Yunuen Hern ández-Sánchez Mar ía Eva González-Trujano Diego A Moreno Heike Vibrans Israel Castillo-Ju árez Alejandro Dorazco-Gonz ález Marcos Soto-Hern ández Source Type: research
Pharmacological evaluation of the anxiolytic-like effects of an aqueous extract of the Raphanus sativus L. sprouts in mice
Biomed Pharmacother. 2023 Mar 27;162:114579. doi: 10.1016/j.biopha.2023.114579. Online ahead of print.ABSTRACTRaphanus sativus L. (Brassicaceae), commonly known as radish, is consumed worldwide as a vegetable. However, its benefits on mental health are unknown. The aim of this study was to evaluate its anxiolytic-like effects and safety using different experimental models. An aqueous extract of R. sativus sprouts (AERSS) was pharmacologically evaluated by intraperitoneal route (i.p.) at 10, 30, and 100 mg/kg and orally (p.o.) at 500 mg/kg on behavior by using open-field and plus-maze tests. In addition, its acute toxicity ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2023 Category: Drugs & Pharmacology Authors: Laura Yunuen Hern ández-Sánchez Mar ía Eva González-Trujano Diego A Moreno Heike Vibrans Israel Castillo-Ju árez Alejandro Dorazco-Gonz ález Marcos Soto-Hern ández Source Type: research
Advances in Pharmacotherapy for Pediatric Anxiety Disorders
The evidence base for psychopharmacologic interventions in children and adolescents with anxiety disorders has significantly increased, and our understanding of the relative efficacy and tolerability of interventions has expanded contemporaneously. Selective serotonin reuptake inhibitors (SSRIs) are the first-line pharmacologic treatment for pediatric anxiety due to their robust efficacy although other agents may have efficacy. This review summarizes the data concerning the use of SSRIs, serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, atypical anxiolytics (eg, 5HT1A agonists, alpha agon...
Source: Child and Adolescent Psychiatric Clinics of North America - March 28, 2023 Category: Psychiatry Authors: Cassandra M. Nicotra, Jeffrey R. Strawn Source Type: research
Buspirone for Comorbid Anxiety in Autism
Prim Care Companion CNS Disord. 2023 Mar 16;25(2):22cr03286. doi: 10.4088/PCC.22cr03286.NO ABSTRACTPMID:36946573 | DOI:10.4088/PCC.22cr03286 (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - March 22, 2023 Category: Primary Care Authors: Mayank Gupta Nihit Gupta Jeffrey Moll Dhanvendran Ramar Source Type: research
Buspirone for Comorbid Anxiety in Autism
Prim Care Companion CNS Disord. 2023 Mar 16;25(2):22cr03286. doi: 10.4088/PCC.22cr03286.NO ABSTRACTPMID:36946573 | DOI:10.4088/PCC.22cr03286 (Source: Primary Care)
Source: Primary Care - March 22, 2023 Category: Primary Care Authors: Mayank Gupta Nihit Gupta Jeffrey Moll Dhanvendran Ramar Source Type: research
