Buspirone for Comorbid Anxiety in Autism
Prim Care Companion CNS Disord. 2023 Mar 16;25(2):22cr03286. doi: 10.4088/PCC.22cr03286.NO ABSTRACTPMID:36946573 | DOI:10.4088/PCC.22cr03286 (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - March 22, 2023 Category: Primary Care Authors: Mayank Gupta Nihit Gupta Jeffrey Moll Dhanvendran Ramar Source Type: research
Buspirone for Comorbid Anxiety in Autism
Prim Care Companion CNS Disord. 2023 Mar 16;25(2):22cr03286. doi: 10.4088/PCC.22cr03286.NO ABSTRACTPMID:36946573 | DOI:10.4088/PCC.22cr03286 (Source: Primary Care)
Source: Primary Care - March 22, 2023 Category: Primary Care Authors: Mayank Gupta Nihit Gupta Jeffrey Moll Dhanvendran Ramar Source Type: research
Buspirone for Comorbid Anxiety in Autism
Prim Care Companion CNS Disord. 2023 Mar 16;25(2):22cr03286. doi: 10.4088/PCC.22cr03286.NO ABSTRACTPMID:36946573 | DOI:10.4088/PCC.22cr03286 (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - March 22, 2023 Category: Primary Care Authors: Mayank Gupta Nihit Gupta Jeffrey Moll Dhanvendran Ramar Source Type: research
Pharmacological treatment for central sleep apnoea in adults
CONCLUSIONS: There is insufficient evidence to support the use of pharmacological therapy in the treatment of CSA. Although small studies have reported positive effects of certain agents for CSA associated with heart failure in reducing the number of respiratory events during sleep, we were unable to assess whether this reduction may impact the quality of life of people with CSA, owing to scarce reporting of important clinical outcomes such as sleep quality or subjective impression of daytime sleepiness. Furthermore, the trials mostly had short-term follow-up. There is a need for high-quality trials that evaluate longer-te...
Source: Cochrane Database of Systematic Reviews - March 2, 2023 Category: General Medicine Authors: Aline Rocha Ana Carolina Pereira Nunes Pinto Daniela V Pachito Luciano F Drager Geraldo Lorenzi-Filho Álvaro N Atallah Source Type: research
Pharmacological treatment for central sleep apnoea in adults
CONCLUSIONS: There is insufficient evidence to support the use of pharmacological therapy in the treatment of CSA. Although small studies have reported positive effects of certain agents for CSA associated with heart failure in reducing the number of respiratory events during sleep, we were unable to assess whether this reduction may impact the quality of life of people with CSA, owing to scarce reporting of important clinical outcomes such as sleep quality or subjective impression of daytime sleepiness. Furthermore, the trials mostly had short-term follow-up. There is a need for high-quality trials that evaluate longer-te...
Source: Cochrane Database of Systematic Reviews - March 2, 2023 Category: General Medicine Authors: Aline Rocha Ana Carolina Pereira Nunes Pinto Daniela V Pachito Luciano F Drager Geraldo Lorenzi-Filho Álvaro N Atallah Source Type: research
Molecules, Vol. 28, Pages 2117: Impact of Pomegranate Juice on the Pharmacokinetics of CYP3A4- and CYP2C9-Mediated Drugs Metabolism: A Preclinical and Clinical Review
halid Matalka
The Punica granatum L. (pomegranate) fruit juice contains large amounts of polyphenols, mainly tannins such as ellagitannin, punicalagin, and punicalin, and flavonoids such as anthocyanins, flavan-3-ols, and flavonols. These constituents have high antioxidant, anti-inflammatory, anti-diabetic, anti-obesity, and anticancer activities. Because of these activities, many patients may consume pomegranate juice (PJ) with or without their doctor’s knowledge. This may raise any significant medication errors or benefits because of food-drug interactions that modulate the drug’s pharmaco...
Source: Molecules - February 24, 2023 Category: Chemistry Authors: Kenza Mansoor Razan Bardees Bayan Alkhawaja Eyad Mallah Luay AbuQatouseh Mathias Schmidt Khalid Matalka Tags: Review Source Type: research
Worsening psychosis associated with administrations of buspirone and concerns for intranasal administration: A case report
We present a case of buspirone worsening psychosis for a patient psychiatrically hospitalized for an episode of decompensated schizoaffective disorder. The patient had a primary diagnosis of schizoaffective disorder and was treated with antipsychotics during this hospitalization, but his symptoms worsened when buspirone was administered on two separate occasions. During the first trial of buspirone, the patient exhibited traits of increased aggression, odd behaviors, and paranoia. The buspirone was discontinued after the patient admitted to hiding his pills to later consume through nasal ingestion. The second trial resulte...
Source: Frontiers in Psychiatry - February 17, 2023 Category: Psychiatry Source Type: research
Pharmacological modulation of conditioned fear in the fear-potentiated startle test: a systematic review and meta-analysis of animal studies
ConclusionsThe fear-potentiated startle test appears to have moderate to high predictive validity and may serve as a valuable tool for the development of novel anxiolytics. Given the limited available data, the generally low study quality and high heterogeneity additional studies are warranted to corroborate the findings of this review. (Source: Psychopharmacology)
Source: Psychopharmacology - January 18, 2023 Category: Psychiatry Source Type: research
Beneficial effects of buspirone in endothelin-1 induced stroke cachexia in rats
Mol Cell Biochem. 2023 Jan 7. doi: 10.1007/s11010-022-04653-4. Online ahead of print.ABSTRACTStroke cachexia is associated with prolonged inflammation, muscle loss, poor prognosis, and early death of stroke patients. No particular treatment is available to cure the symptoms or disease. The present study aimed to evaluate the effect of a 5-HT1a agonist, buspirone on stroke cachexia. Wistar rats were injected with endothelin-1 to the bregma region of the brain to induce ischemic stroke followed by induction of cachexia after 4 days. Treatment with buspirone (3 mg/kg p.o) was given for 4 weeks after confirmation of cachexia i...
Source: Molecular and Cellular Biochemistry - January 7, 2023 Category: Biochemistry Authors: Darshak Shah Mit Joshi Jigna Shah Bhoomika M Patel Source Type: research
Molecules, Vol. 27, Pages 8058: High-Throughput Metabolic Soft-Spot Identification in Liver Microsomes by LC/UV/MS: Application of a Single Variable Incubation Time Approach
ngliang Jiang
CYP-mediated fast metabolism may lead to poor bioavailability, fast drug clearance and significant drug interaction. Thus, metabolic stability screening in human liver microsomes (HLM) followed by metabolic soft-spot identification (MSSID) is routinely conducted in drug discovery. Liver microsomal incubations of testing compounds with fixed single or multiple incubation time(s) and quantitative and qualitative analysis of metabolites using high-resolution mass spectrometry are routinely employed in MSSID assays. The major objective of this study was to develop and validate a simple, effective, and high-th...
Source: Molecules - November 20, 2022 Category: Chemistry Authors: Yanlin Zhu Guiying Chen Kerong Zhang Chang Chen Weiqing Chen Chen Mingshe Zhu Hongliang Jiang Tags: Article Source Type: research
Gastric Glitch: A New Functional Disease Treated with Buspirone and Prucalopride in an N-of-1 Double-Blind Clinical Trial
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 12, 2022 Category: Drugs & Pharmacology Source Type: research
Use of central nervous system drugs in combination with selective serotonin reuptake inhibitor treatment: A Bayesian screening study for risk of suicidal behavior
ConclusionSeveral of the detected signals for reduced risk correspond to drugs where there is previous evidence of benefit for antidepressant augmentation (e.g., olanzapine, quetiapine, lithium, buspirone, and mirtazapine). Novel signals of reduced suicidal behavior risk, including for lamotrigine, valproic acid, risperidone, and melatonin, warrant further investigation. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - November 9, 2022 Category: Psychiatry Source Type: research
Effects of Age, Sex, and Comedication on the Plasma Concentrations of Olanzapine in Chinese Patients With Schizophrenia Based on Therapeutic Drug Monitoring Data
Conclusions
The administered drug's dose was identified as an important determinant of the achieved OLA plasma concentration, with a positive correlation. The patients' sex and valproate (or lithium) comedication can significantly affect the C/D of OLA. Therapeutic drug monitoring should be routinely applied in cases of OLA-receiving patients with schizophrenia. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - November 1, 2022 Category: Psychiatry Tags: Original Contributions Source Type: research
Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals
Dose Response. 2022 Sep 21;20(3):15593258221120485. doi: 10.1177/15593258221120485. eCollection 2022 Jul-Sep.ABSTRACTPhytochemicals (Pch) present in fruits, vegetables and other foods, are known to inhibit or induce drug metabolism and transport. An exhaustive search was performed in five databases covering from 2000 to 2021. Twenty-one compounds from plants were found to modulate CYP3A and/or P-gp activities and modified the pharmacokinetics and the therapeutic effect of 27 different drugs. Flavonols, flavanones, flavones, stilbenes, diferuloylmethanes, tannins, protoalkaloids, flavans, hyperforin and terpenes, reduce pla...
Source: Dose Response - September 26, 2022 Category: Drugs & Pharmacology Authors: Josefina G ómez-Garduño Renato Le ón-Rodríguez Radam és Alemón-Medina Beatriz E P érez-Guillé Rosa E Soriano-Rosales Ailema Gonz ález-Ortiz Juan L Ch ávez-Pacheco Edelmira Solorio-L ópez Paola Fernandez-P érez Liliana Rivera-Espinosa Source Type: research
