Ferric iron loaded porphyrinic zirconium MOFs on corncob for the enhancement of diuretics extraction
Chemosphere. 2022 Apr 23:134694. doi: 10.1016/j.chemosphere.2022.134694. Online ahead of print.ABSTRACTHerein, corncob waste was used as a scaffold for the fabrication of effective adsorbents. Porphyrinic zirconium metal-organic frameworks (MOFs) PCN-223 and PCN-224 constructed by different numbers of Zr6 cluster nodes were grown on the surface of the corncob. Fe (Ш) ions were implanted in the porphyrin ring by post-synthesis modification. The results showed that the extraction capacity of diuretics on PCN-224@corncob containing suitable pore size was larger than that of PCN-223@corncob. The adsorption of diuretics was fu...
Source: Chemosphere - April 26, 2022 Category: Chemistry Authors: Nan Zhang Yan Gao Kangjia Sheng Xianliang Xu Wanghui Jing Tao Bao Sicen Wang Source Type: research
Ferric iron loaded porphyrinic zirconium MOFs on corncob for the enhancement of diuretics extraction
Chemosphere. 2022 Apr 23:134694. doi: 10.1016/j.chemosphere.2022.134694. Online ahead of print.ABSTRACTHerein, corncob waste was used as a scaffold for the fabrication of effective adsorbents. Porphyrinic zirconium metal-organic frameworks (MOFs) PCN-223 and PCN-224 constructed by different numbers of Zr6 cluster nodes were grown on the surface of the corncob. Fe (Ш) ions were implanted in the porphyrin ring by post-synthesis modification. The results showed that the extraction capacity of diuretics on PCN-224@corncob containing suitable pore size was larger than that of PCN-223@corncob. The adsorption of diuretics was fu...
Source: Chemosphere - April 26, 2022 Category: Chemistry Authors: Nan Zhang Yan Gao Kangjia Sheng Xianliang Xu Wanghui Jing Tao Bao Sicen Wang Source Type: research
Ferric iron loaded porphyrinic zirconium MOFs on corncob for the enhancement of diuretics extraction
Chemosphere. 2022 Apr 23:134694. doi: 10.1016/j.chemosphere.2022.134694. Online ahead of print.ABSTRACTHerein, corncob waste was used as a scaffold for the fabrication of effective adsorbents. Porphyrinic zirconium metal-organic frameworks (MOFs) PCN-223 and PCN-224 constructed by different numbers of Zr6 cluster nodes were grown on the surface of the corncob. Fe (Ш) ions were implanted in the porphyrin ring by post-synthesis modification. The results showed that the extraction capacity of diuretics on PCN-224@corncob containing suitable pore size was larger than that of PCN-223@corncob. The adsorption of diuretics was fu...
Source: Chemosphere - April 26, 2022 Category: Chemistry Authors: Nan Zhang Yan Gao Kangjia Sheng Xianliang Xu Wanghui Jing Tao Bao Sicen Wang Source Type: research
Ferric iron loaded porphyrinic zirconium MOFs on corncob for the enhancement of diuretics extraction
Chemosphere. 2022 Apr 23:134694. doi: 10.1016/j.chemosphere.2022.134694. Online ahead of print.ABSTRACTHerein, corncob waste was used as a scaffold for the fabrication of effective adsorbents. Porphyrinic zirconium metal-organic frameworks (MOFs) PCN-223 and PCN-224 constructed by different numbers of Zr6 cluster nodes were grown on the surface of the corncob. Fe (Ш) ions were implanted in the porphyrin ring by post-synthesis modification. The results showed that the extraction capacity of diuretics on PCN-224@corncob containing suitable pore size was larger than that of PCN-223@corncob. The adsorption of diuretics was fu...
Source: Chemosphere - April 26, 2022 Category: Chemistry Authors: Nan Zhang Yan Gao Kangjia Sheng Xianliang Xu Wanghui Jing Tao Bao Sicen Wang Source Type: research
The impact of Morus alba L. leaf extract on intestinal ion transport. An in vitro study
Biomed Pharmacother. 2022 Apr 20;150:112939. doi: 10.1016/j.biopha.2022.112939. Online ahead of print.ABSTRACTMorus alba L. (White mulberry), is an important and popular herbal plant of the Moraceae family. It has been widely used due to its therapeutic properties, which include antidiabetic, antibacterial, anti-inflammatory, cardiovascular, and hypolpidemic activity. The present study evaluates the effects of aqueous white mulberry leaf extract on the transepithelial ion pathway in the rabbit colon epithelium (n = 48), using electrophysiological methods. In addition, the antioxidant potential and the chemical composition ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 23, 2022 Category: Drugs & Pharmacology Authors: Anna Gryn-Rynko Iga Ho łyńska-Iwan Micha ł Adam Janiak Dorota Olszewska-S łonina Ryszard Amarowicz Radomir Graczyk Source Type: research
The impact of Morus alba L. leaf extract on intestinal ion transport. An in vitro study
Biomed Pharmacother. 2022 Apr 20;150:112939. doi: 10.1016/j.biopha.2022.112939. Online ahead of print.ABSTRACTMorus alba L. (White mulberry), is an important and popular herbal plant of the Moraceae family. It has been widely used due to its therapeutic properties, which include antidiabetic, antibacterial, anti-inflammatory, cardiovascular, and hypolpidemic activity. The present study evaluates the effects of aqueous white mulberry leaf extract on the transepithelial ion pathway in the rabbit colon epithelium (n = 48), using electrophysiological methods. In addition, the antioxidant potential and the chemical composition ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 23, 2022 Category: Drugs & Pharmacology Authors: Anna Gryn-Rynko Iga Ho łyńska-Iwan Micha ł Adam Janiak Dorota Olszewska-S łonina Ryszard Amarowicz Radomir Graczyk Source Type: research
Molecules, Vol. 27, Pages 2440: Beta-Amyloid (A & beta;1-42) Increases the Expression of NKCC1 in the Mouse Hippocampus
This study used primary mouse hippocampal neurons to explore if KCC2 and NKCC1 expression levels are altered following beta-amyloid (Aβ1-42) treatment and the potential neuroprotective effects of bumetanide. KCC2 and NKCC1 expression levels were also examined in 18-months-old male C57BL/6 mice following bilateral hippocampal Aβ1-42 stereotaxic injection. No change in KCC2 and NKCC1 expression levels were observed in mouse hippocampal neurons treated with 1 nM Aβ1-42, but NKCC1 expression increased 30-days post-Aβ1-42-injection in the CA1 region of the mouse hippocampus. P...
Source: Molecules - April 10, 2022 Category: Chemistry Authors: Patricia Lam Chitra Vinnakota Beatriz Calvo-Flores Guzma ́n Julia Newland Katie Peppercorn Warren P. Tate Henry J. Waldvogel Richard L. M. Faull Andrea Kwakowsky Tags: Article Source Type: research
A Comprehensive Review of the Pharmacologic Perspective on Loop Diuretic Drug Interactions with Therapeutically Used Drugs
CONCLUSION: Clinicians, pharmacists and other health care providers should take responsibility for the safe use of medications. In addition, they are required to be aware of the drugs interacting with loop diuretics, to prevent adverse drug interactions.PMID:35366769 | DOI:10.2174/1389200223666220401092112 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 3, 2022 Category: Drugs & Pharmacology Authors: Naina Mohamed Pakkir Maideen Rajkapoor Balasubramanian Sudha Muthusamy Source Type: research
A Comprehensive Review of the Pharmacologic Perspective on Loop Diuretic Drug Interactions with Therapeutically Used Drugs
CONCLUSION: Clinicians, pharmacists and other health care providers should take responsibility for the safe use of medications. In addition, they are required to be aware of the drugs interacting with loop diuretics, to prevent adverse drug interactions.PMID:35366769 | DOI:10.2174/1389200223666220401092112 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 3, 2022 Category: Drugs & Pharmacology Authors: Naina Mohamed Pakkir Maideen Rajkapoor Balasubramanian Sudha Muthusamy Source Type: research
A Phase III Study of Bumetanide Oral Liquid Formulation for the Treatment of Children and Adolescents Aged Between 7 and 17 Years with Autism Spectrum Disorder (SIGN 1 Trial): Participant Baseline Characteristics
Child Psychiatry Hum Dev. 2022 Mar 16. doi: 10.1007/s10578-022-01328-5. Online ahead of print.ABSTRACTThe efficacy of bumetanide (oral liquid formulation 0.5 mg bid) as a treatment for the core symptoms of autism spectrum disorders in children and adolescents aged 7-17 years is being investigated in an international, randomised, double-blind, placebo-controlled phase III study. The primary endpoint is the change in Childhood Autism Rating Scale 2 (CARS2) total raw score after 6 months of treatment. At baseline, the 211 participants analysed are broadly representative of autistic subjects in this age range: mean (SD) age, 1...
Source: Child Psychiatry and Human Development - March 16, 2022 Category: Child Development Authors: Christina Georgoula Maite Ferrin Bozena Pietraszczyk-Kedziora Amaia Hervas St éphane Marret Guiomar Oliveira Antoine Rosier V éronique Crutel Emmanuelle Besse Cristina Albarr án Severo Denis Ravel Joaquin Fuentes Source Type: research
Pharmacological and dietary-supplement treatments for autism spectrum disorder: a systematic review and network meta-analysis
ConclusionsSome medications could improve core symptoms, although this could be likely secondary to the improvement of associated symptoms. Evidence on their efficacy and safety is preliminary; therefore, routine prescription of medications for the core symptoms cannot be recommended.Trial registration PROSPERO-ID CRD42019125317. (Source: Molecular Autism)
Source: Molecular Autism - March 4, 2022 Category: Molecular Biology Source Type: research
Sequence analysis and function of mosquito aeCCC2 and Drosophila Ncc83 orthologs
Insect Biochem Mol Biol. 2022 Feb 9:103729. doi: 10.1016/j.ibmb.2022.103729. Online ahead of print.ABSTRACTDipteran insects have genes that code for two different Na+-dependent cation-chloride cotransporter (CCC) paralogs. Aedes aegypti aeNKCC1 is an ortholog of Drosophila melanogaster Ncc69, a bumetanide-sensitive Na+-K+-2Cl- cotransporter (NKCC). Aedes aegypti aeCCC2 and aeCCC3 are orthologs of Drosophila Ncc83. Prior work suggests that the transport properties of aeCCC2 differ from canonical NKCCs. In particular, Xenopus oocytes expressing aeCCC2 have increased Na + -dependent membrane currents compared to controls, whe...
Source: Insect Biochemistry and Molecular Biology - February 12, 2022 Category: Biochemistry Authors: Phu C Duong Tobias C McCabe Grace F Riley Heather L Holmes Peter M Piermarini Michael F Romero Christopher M Gillen Source Type: research
Sequence analysis and function of mosquito aeCCC2 and Drosophila Ncc83 orthologs
Insect Biochem Mol Biol. 2022 Feb 9:103729. doi: 10.1016/j.ibmb.2022.103729. Online ahead of print.ABSTRACTDipteran insects have genes that code for two different Na+-dependent cation-chloride cotransporter (CCC) paralogs. Aedes aegypti aeNKCC1 is an ortholog of Drosophila melanogaster Ncc69, a bumetanide-sensitive Na+-K+-2Cl- cotransporter (NKCC). Aedes aegypti aeCCC2 and aeCCC3 are orthologs of Drosophila Ncc83. Prior work suggests that the transport properties of aeCCC2 differ from canonical NKCCs. In particular, Xenopus oocytes expressing aeCCC2 have increased Na + -dependent membrane currents compared to controls, whe...
Source: Insect Biochemistry and Molecular Biology - February 12, 2022 Category: Biochemistry Authors: Phu C Duong Tobias C McCabe Grace F Riley Heather L Holmes Peter M Piermarini Michael F Romero Christopher M Gillen Source Type: research
Sequence analysis and function of mosquito aeCCC2 and Drosophila Ncc83 orthologs
Insect Biochem Mol Biol. 2022 Feb 9:103729. doi: 10.1016/j.ibmb.2022.103729. Online ahead of print.ABSTRACTDipteran insects have genes that code for two different Na+-dependent cation-chloride cotransporter (CCC) paralogs. Aedes aegypti aeNKCC1 is an ortholog of Drosophila melanogaster Ncc69, a bumetanide-sensitive Na+-K+-2Cl- cotransporter (NKCC). Aedes aegypti aeCCC2 and aeCCC3 are orthologs of Drosophila Ncc83. Prior work suggests that the transport properties of aeCCC2 differ from canonical NKCCs. In particular, Xenopus oocytes expressing aeCCC2 have increased Na + -dependent membrane currents compared to controls, whe...
Source: Insect Biochemistry and Molecular Biology - February 12, 2022 Category: Biochemistry Authors: Phu C Duong Tobias C McCabe Grace F Riley Heather L Holmes Peter M Piermarini Michael F Romero Christopher M Gillen Source Type: research
Sequence analysis and function of mosquito aeCCC2 and Drosophila Ncc83 orthologs
Insect Biochem Mol Biol. 2022 Feb 9:103729. doi: 10.1016/j.ibmb.2022.103729. Online ahead of print.ABSTRACTDipteran insects have genes that code for two different Na+-dependent cation-chloride cotransporter (CCC) paralogs. Aedes aegypti aeNKCC1 is an ortholog of Drosophila melanogaster Ncc69, a bumetanide-sensitive Na+-K+-2Cl- cotransporter (NKCC). Aedes aegypti aeCCC2 and aeCCC3 are orthologs of Drosophila Ncc83. Prior work suggests that the transport properties of aeCCC2 differ from canonical NKCCs. In particular, Xenopus oocytes expressing aeCCC2 have increased Na + -dependent membrane currents compared to controls, whe...
Source: Insect Biochemistry and Molecular Biology - February 12, 2022 Category: Biochemistry Authors: Phu C Duong Tobias C McCabe Grace F Riley Heather L Holmes Peter M Piermarini Michael F Romero Christopher M Gillen Source Type: research
