Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios
Translational Psychiatry, Published online: 27 January 2020; doi:10.1038/s41398-020-0692-2Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios (Source: Translational Psychiatry)
Source: Translational Psychiatry - January 26, 2020 Category: Psychiatry Authors: Lingli Zhang Chu-Chung Huang Yuan Dai Qiang Luo Yiting Ji Kai Wang Shining Deng Juehua Yu Mingyu Xu Xiujuan Du Yun Tang Chun Shen Jianfeng Feng Barbara J Sahakian Ching-Po Lin Fei Li Source Type: research
Successive clinical application of vitamin D and bumetanide in children with autism spectrum disorder: A case report
Rationale:
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder caused by complex interactions between genetic and environmental factors. Recent studies suggest that Vitamin D3 or bumetanide therapy may improve the core symptoms of ASD in some individuals. However, there are no guidelines that provide clinicians with evidence-based treatment regimens for the use of these therapies in ASD.
Patient concerns:
A 30-month-old female was referred to our department because she did not respond when her name was called.
Diagnosis:
The patient was diagnosed with ASD by a team of autism experts according to ...
Source: Medicine - January 1, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
[ASAP] Novel Pharmaceutical Cocrystals and Salts of Bumetanide
Crystal Growth& DesignDOI: 10.1021/acs.cgd.9b01195 (Source: Crystal Growth and Design)
Source: Crystal Growth and Design - December 30, 2019 Category: Chemistry Authors: Suryanarayana Allu †, Geetha Bolla†, Srinu Tothadi‡, and Ashwini K. Nangia*†‡ Source Type: research
Screening for efficacious anticonvulsants and neuroprotectants in delayed treatment models of organophosphate-induced status epilepticus
Publication date: Available online 26 November 2019Source: NeuroscienceAuthor(s): Bryan S. Barker, Jay Spampanato, Hilary S. McCarren, Melissa Smolik, Cecelia E. Jackson, Eden N. Hornung, David T. Yeung, F. Edward Dudek, John H. McDonoughAbstractOrganophosphorus (OP) compounds are deadly chemicals that exert their intoxicating effects through the irreversible inhibition of acetylcholinesterase (AChE). In addition to an excess of peripheral ailments, OP intoxication induces status epilepticus (SE) which if left untreated may lead to permanent brain damage or death. Benzodiazepines are typically the primary therapies for OP-...
Source: Neuroscience - November 28, 2019 Category: Neuroscience Source Type: research
Impaired chloride homeostasis in epilepsy: Molecular basis, impact on treatment, and current treatment approaches
Publication date: Available online 15 October 2019Source: Pharmacology & TherapeuticsAuthor(s): Theresa Auer, Philipp Schreppel, Thomas Erker, Christoph SchwarzerAbstractEpilepsies represent one of the most common neurological diseases worldwide. They are characterized by recurrent spontaneous seizures with severe impact on a patient’s life. An imbalance in excitatory and inhibitory signalling is considered the main underlying pathophysiological mechanism. Therefore, GABA-mimetic drugs, strengthening the main inhibitory signalling system in the CNS, are frequently used as antiepileptic or anticonvulsant drugs. However, t...
Source: Pharmacology and Therapeutics - October 16, 2019 Category: Drugs & Pharmacology Source Type: research
