Diuretic a Promising Treatment for Autism Diuretic a Promising Treatment for Autism
The diuretic bumetanide improves some of the core symptoms of autism by decreasing levels of the neurotransmitters gamma-aminobutyric acid, new research shows.Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - January 30, 2020 Category: Psychiatry Tags: Psychiatry News Source Type: news

Study Shows ‘ Water Pill ’ May Help Reduce Some Autism Symptoms In Young Kids
BOSTON (CBS) — A drug that has been used to treat heart failure for decades may improve behavioral symptoms in some young children with autism. Bumetanide is a diuretic, which is used to treat the buildup of fluid in the body. Researchers in China and at the University of Cambridge looked at 83 kids between three and six years old and found that, three months later, the children treated with the diuretic scored better on a behavior scale which measures emotional response as well as verbal and non-verbal communication. They believe the drug helps nerve cells communicate more effectively by reducing the level of a...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 27, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated CBSN Boston Syndicated Local Autism Dr. Mallika Marshall Source Type: news

Could Common Diuretic Medicidne Bumetanide Help Ease Autism Symptoms?
MONDAY, Jan. 27, 2020 -- A prescription drug that's long been used to treat the buildup of fluid in the body might do double duty as a means of easing autism symptoms in young children, new research shows. If replicated in future trials, the drug... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 27, 2020 Category: General Medicine Source Type: news

Prescription drug improves symptoms of autism by targeting brain's chemical messengers
(University of Cambridge) Bumetanide -- a prescription drug for oedema (the build-up of fluid in the body) -- improves some of the symptoms in young children with autism spectrum disorders and has no significant side effects, according to a new study from researchers in China and the UK. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 26, 2020 Category: International Medicine & Public Health Source Type: news

Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology
KCC2 is a vital neuronal K+/Cl– cotransporter that is implicated in the etiology of numerous neurological diseases. In normal cells, KCC2 undergoes developmental dephosphorylation at Thr906 and Thr1007. We engineered mice with heterozygous phosphomimetic mutations T906E and T1007E (KCC2E/+) to prevent the normal developmental dephosphorylation of these sites. Immature (postnatal day 15) but not juvenile (postnatal day 30) KCC2E/+ mice exhibited altered GABAergic inhibition, an increased glutamate/GABA synaptic ratio, and greater susceptibility to seizure. KCC2E/+ mice also had abnormal ultrasonic vocalizations at pos...
Source: Signal Transduction Knowledge Environment - October 15, 2019 Category: Science Authors: Pisella, L. I., Gaiarsa, J.-L., Diabira, D., Zhang, J., Khalilov, I., Duan, J., Kahle, K. T., Medina, I. Tags: STKE Research Articles Source Type: news

Lasix (furosemide) vs. bumetanide
Title: Lasix (furosemide) vs. bumetanideCategory: MedicationsCreated: 6/6/2019 12:00:00 AMLast Editorial Review: 6/6/2019 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - June 6, 2019 Category: Cardiology Source Type: news

bumetanide, Bumex (discontinued brand)
Title: bumetanide, Bumex (discontinued brand)Category: MedicationsCreated: 6/6/1999 12:00:00 AMLast Editorial Review: 3/15/2019 12:00:00 AM (Source: MedicineNet High Blood Pressure General)
Source: MedicineNet High Blood Pressure General - March 15, 2019 Category: Cardiology Source Type: news

Bumetanide Injection, USP (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - January 25, 2018 Category: Drugs & Pharmacology Source Type: news

Bumetanide Injection, USP (New - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - December 13, 2017 Category: Drugs & Pharmacology Source Type: news

Bumex (Bumetanide) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 22, 2017 Category: Drugs & Pharmacology Source Type: news

Diuretic Continues to Show Promise in Autism Diuretic Continues to Show Promise in Autism
The diuretic bumetanide improved the core symptoms of autism spectrum disorder in a phase 2b study and will be tested in an upcoming phase 3 study in Europe.Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - March 22, 2017 Category: Psychiatry Tags: Psychiatry News Source Type: news

Bumetanide Promising for Reducing Autism Symptoms
Decrease in GABA/glutamate ratio in insular cortex tied to symptom improvement in bumetanide group (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - November 11, 2014 Category: Psychiatry Tags: Family Medicine, Neurology, Pediatrics, Pharmacy, Psychiatry, Radiology, Journal, Source Type: news

Intrathecal bumetanide has analgesic effects through inhibition of NKCC1
(Neural Regeneration Research) Accumulating evidence has demonstrated that the sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 have a role in the modulation of pain transmission at the spinal level through chloride regulation in the pain pathway and by effecting neuronal excitability and pain sensitization. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 16, 2014 Category: Global & Universal Source Type: news

Comparison Of 3 Water Pills For Heart Failure Finds The Most Effective May Be The Least Prescribed
Loop diuretics, more commonly known as water pills, are the most widely prescribed heart failure medications, but few studies had extensively compared their effectiveness until Yale School of Medicine researchers examined three approved loop diuretics and found that even though one of them might offer more benefit, it is rarely prescribed. Published in the early edition of the Journal of the American College of Cardiology, the research compared the potential benefits of using one of three loop diuretics: toresemide, furosemide, and bumetanide... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 3, 2013 Category: Consumer Health News Tags: Heart Disease Source Type: news

Updated national IV monograph on Bumetanide
Source: Medusa Area: News An updated IV monograph on Bumetanide is now available from the NHS injectable medicines guide website (Medusa). Please see the link below for access (registration required). (Source: NeLM - News)
Source: NeLM - News - February 21, 2013 Category: Drugs & Pharmacology Source Type: news