Evaluation of bumetanide as a potential therapeutic agent for Alzheimer ’s disease
Therapeutics discovery and development for Alzheimer’s disease (AD) has been an area of intense research to alleviate memory loss and the underlying pathogenic processes. Recent drug discovery approaches have utilized in silico computational strategies for drug candidate selection which has opened the door to repurposing drugs for AD. Computational analysis of gene expression signatures of patients stratified by the APOE4 risk allele of AD led to the discovery of the FDA-approved drug bumetanide as a top candidate agent that reverses APOE4 transcriptomic brain signatures and improves memory deficits in APOE4 animal model...
Source: Frontiers in Pharmacology - August 4, 2023 Category: Drugs & Pharmacology Source Type: research
Dietary Na < sup > + < /sup > depletion up-regulates NKCC1 expression and enhances electrogenic Cl < sup > - < /sup > secretion in rat proximal colon
Cell Mol Life Sci. 2023 Jul 17;80(8):209. doi: 10.1007/s00018-023-04857-x.ABSTRACTThe corticosteroid hormone, aldosterone, markedly enhances K+ secretion throughout the colon, a mechanism critical to its role in maintaining overall K+ balance. Previous studies demonstrated that basolateral NKCC1 was up-regulated by aldosterone in the distal colon specifically to support K+ secretion-which is distinct from the more well-established role of NKCC1 in supporting luminal Cl- secretion. However, considerable segmental variability exists between proximal and distal colonic ion transport processes, especially concerning their regu...
Source: Cellular and Molecular Life Sciences : CMLS - July 17, 2023 Category: Cytology Authors: Andrew J Nickerson Vazhaikkurichi M Rajendran Source Type: research
Dietary Na < sup > + < /sup > depletion up-regulates NKCC1 expression and enhances electrogenic Cl < sup > - < /sup > secretion in rat proximal colon
Cell Mol Life Sci. 2023 Jul 17;80(8):209. doi: 10.1007/s00018-023-04857-x.ABSTRACTThe corticosteroid hormone, aldosterone, markedly enhances K+ secretion throughout the colon, a mechanism critical to its role in maintaining overall K+ balance. Previous studies demonstrated that basolateral NKCC1 was up-regulated by aldosterone in the distal colon specifically to support K+ secretion-which is distinct from the more well-established role of NKCC1 in supporting luminal Cl- secretion. However, considerable segmental variability exists between proximal and distal colonic ion transport processes, especially concerning their regu...
Source: Cellular and Molecular Life Sciences : CMLS - July 17, 2023 Category: Cytology Authors: Andrew J Nickerson Vazhaikkurichi M Rajendran Source Type: research
Bumetanide Attenuates Cognitive Deficits and Brain Damage in Rats Subjected to Hypoxia-Ischemia at Two Time Points of the Early Postnatal Period
Neurotox Res. 2023 Jun 28. doi: 10.1007/s12640-023-00654-3. Online ahead of print.ABSTRACTNeonatal hypoxia-ischemia (HI) is one of the main causes of tissue damage, cell death, and imbalance between neuronal excitation and inhibition and synaptic loss in newborns. GABA, the major inhibitory neurotransmitter of the central nervous system (CNS) in adults, is excitatory at the onset of neurodevelopment and its action depends on the chloride (Cl-) cotransporters NKCC1 (imports Cl-) and KCC2 (exports Cl-) expression. Under basal conditions, the NKCC1/KCC2 ratio decreases over neurodevelopment. Thus, changes in this ratio caused...
Source: Cell Research - June 28, 2023 Category: Cytology Authors: Diorlon Nunes Machado Luz Elena Dur án-Carabali Felipe Kawa Odorcyk Andrey Vinicios Soares Carvalho Ana Paula Rodrigues Martini Livia Machado Schlemmer Marcel de Medeiros de Mattos Gabriel Pereira Bernd Carla Dalmaz Carlos Alexandre Netto Source Type: research
Efficacy of bumetanide tablets combined with valsartan in the treatment of elderly patients with chronic glomerulonephritis and its effects on renal function and hemodynamics
CONCLUSION: Bumetanide tablets combined with valsartan are remarkably effective for elderly patients with CGN. This combined method can substantially improve the renal function and hemodynamics of the patients, so it has a high clinical application value in the future.PMID:37303676 | PMC:PMC10250995 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 12, 2023 Category: Research Authors: Shanshan Zhang Jihong Wang Yali Liu Xi Yu Chen Chen Source Type: research
