Bumetanide potentiates the anti-seizure and disease-modifying effects of midazolam in a noninvasive rat model of term birth asphyxia
Epilepsy Behav. 2023 Apr 8;142:109189. doi: 10.1016/j.yebeh.2023.109189. Online ahead of print.ABSTRACTBirth asphyxia and the resulting hypoxic-ischemic encephalopathy (HIE) are highly associated with perinatal and neonatal death, neonatal seizures, and an adverse later-life outcome. Currently used drugs, including phenobarbital and midazolam, have limited efficacy to suppress neonatal seizures. There is a medical need to develop new therapies that not only suppress neonatal seizures but also prevent later-life consequences. We have previously shown that the loop diuretic bumetanide does not potentiate the effects of pheno...
Source: Epilepsy and Behaviour - April 10, 2023 Category: Neurology Authors: Bj örn Welzel Marie Johne Wolfgang L öscher Source Type: research
Bumetanide potentiates the anti-seizure and disease-modifying effects of midazolam in a noninvasive rat model of term birth asphyxia
Epilepsy Behav. 2023 Apr 8;142:109189. doi: 10.1016/j.yebeh.2023.109189. Online ahead of print.ABSTRACTBirth asphyxia and the resulting hypoxic-ischemic encephalopathy (HIE) are highly associated with perinatal and neonatal death, neonatal seizures, and an adverse later-life outcome. Currently used drugs, including phenobarbital and midazolam, have limited efficacy to suppress neonatal seizures. There is a medical need to develop new therapies that not only suppress neonatal seizures but also prevent later-life consequences. We have previously shown that the loop diuretic bumetanide does not potentiate the effects of pheno...
Source: Epilepsy and Behaviour - April 10, 2023 Category: Neurology Authors: Bj örn Welzel Marie Johne Wolfgang L öscher Source Type: research
Bumetanide, a Diuretic That Can Help Children with Autism Spectrum Disorder
CONCLUSION: Bumetanide has an important role in the treatment of core symptoms of ASD.PMID:37021422 | DOI:10.2174/1871527322666230404114911 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - April 6, 2023 Category: Drugs & Pharmacology Authors: Esraa Shaker Osama El Agami Abeer Salamah Source Type: research
Bumetanide, a Diuretic That Can Help Children with Autism Spectrum Disorder
CONCLUSION: Bumetanide has an important role in the treatment of core symptoms of ASD.PMID:37021422 | DOI:10.2174/1871527322666230404114911 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - April 6, 2023 Category: Drugs & Pharmacology Authors: Esraa Shaker Osama El Agami Abeer Salamah Source Type: research
Developmental changes in brain activity of heterozygous Scn1a knockout rats
ConclusionsIn Scn1a+/− rats, neural activity in widespread brain regions increased during the third postnatal week, corresponding to approximately 6 months of age in humans, when seizures most commonly develop in DS. In addition to impairment of GABAergic interneurons, the effects of bumetanide suggest a possible contribution of immature type A gamma-aminobutyric acid receptor signaling to transient hyperactivity and seizure susceptibility during the early stage of DS. This hypothesis should be addressed in the future. MEMRI is a potential technique for visualizing changes in basal brain activity in developmental and epi...
Source: Frontiers in Neurology - March 14, 2023 Category: Neurology Source Type: research
A novel mouse model for an inducible gene-modification in the renal thick ascending limb
Am J Physiol Renal Physiol. 2023 Mar 9. doi: 10.1152/ajprenal.00250.2022. Online ahead of print.ABSTRACTThe thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant in the luminal membrane of TAL cells. TAL function is regulated by various hormonal and non-hormonal factors. However, many of the underlying signal transduction pathways remain elusive. Here, we describe and characterize a novel gene-modified mouse model for an inducible and specific Cre/Lox-media...
Source: American Journal of Physiology. Renal Physiology - March 9, 2023 Category: Physiology Authors: Laurent Bourqui Denise V Winter Alex Odermatt Dominique Loffing-Cueni Johannes Loffing Source Type: research
A novel mouse model for an inducible gene-modification in the renal thick ascending limb
Am J Physiol Renal Physiol. 2023 Mar 9. doi: 10.1152/ajprenal.00250.2022. Online ahead of print.ABSTRACTThe thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant in the luminal membrane of TAL cells. TAL function is regulated by various hormonal and non-hormonal factors. However, many of the underlying signal transduction pathways remain elusive. Here, we describe and characterize a novel gene-modified mouse model for an inducible and specific Cre/Lox-media...
Source: Am J Physiol Renal P... - March 9, 2023 Category: Urology & Nephrology Authors: Laurent Bourqui Denise V Winter Alex Odermatt Dominique Loffing-Cueni Johannes Loffing Source Type: research
A novel mouse model for an inducible gene-modification in the renal thick ascending limb
Am J Physiol Renal Physiol. 2023 Mar 9. doi: 10.1152/ajprenal.00250.2022. Online ahead of print.ABSTRACTThe thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant in the luminal membrane of TAL cells. TAL function is regulated by various hormonal and non-hormonal factors. However, many of the underlying signal transduction pathways remain elusive. Here, we describe and characterize a novel gene-modified mouse model for an inducible and specific Cre/Lox-media...
Source: American Journal of Physiology. Renal Physiology - March 9, 2023 Category: Physiology Authors: Laurent Bourqui Denise V Winter Alex Odermatt Dominique Loffing-Cueni Johannes Loffing Source Type: research
A novel mouse model for an inducible gene-modification in the renal thick ascending limb
Am J Physiol Renal Physiol. 2023 Mar 9. doi: 10.1152/ajprenal.00250.2022. Online ahead of print.ABSTRACTThe thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant in the luminal membrane of TAL cells. TAL function is regulated by various hormonal and non-hormonal factors. However, many of the underlying signal transduction pathways remain elusive. Here, we describe and characterize a novel gene-modified mouse model for an inducible and specific Cre/Lox-media...
Source: Am J Physiol Renal P... - March 9, 2023 Category: Urology & Nephrology Authors: Laurent Bourqui Denise V Winter Alex Odermatt Dominique Loffing-Cueni Johannes Loffing Source Type: research
A novel mouse model for an inducible gene-modification in the renal thick ascending limb
Am J Physiol Renal Physiol. 2023 Mar 9. doi: 10.1152/ajprenal.00250.2022. Online ahead of print.ABSTRACTThe thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant in the luminal membrane of TAL cells. TAL function is regulated by various hormonal and non-hormonal factors. However, many of the underlying signal transduction pathways remain elusive. Here, we describe and characterize a novel gene-modified mouse model for an inducible and specific Cre/Lox-media...
Source: American Journal of Physiology. Renal Physiology - March 9, 2023 Category: Physiology Authors: Laurent Bourqui Denise V Winter Alex Odermatt Dominique Loffing-Cueni Johannes Loffing Source Type: research
A novel mouse model for an inducible gene-modification in the renal thick ascending limb
Am J Physiol Renal Physiol. 2023 Mar 9. doi: 10.1152/ajprenal.00250.2022. Online ahead of print.ABSTRACTThe thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant in the luminal membrane of TAL cells. TAL function is regulated by various hormonal and non-hormonal factors. However, many of the underlying signal transduction pathways remain elusive. Here, we describe and characterize a novel gene-modified mouse model for an inducible and specific Cre/Lox-media...
Source: Am J Physiol Renal P... - March 9, 2023 Category: Urology & Nephrology Authors: Laurent Bourqui Denise V Winter Alex Odermatt Dominique Loffing-Cueni Johannes Loffing Source Type: research
A novel mouse model for an inducible gene-modification in the renal thick ascending limb
Am J Physiol Renal Physiol. 2023 Mar 9. doi: 10.1152/ajprenal.00250.2022. Online ahead of print.ABSTRACTThe thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant in the luminal membrane of TAL cells. TAL function is regulated by various hormonal and non-hormonal factors. However, many of the underlying signal transduction pathways remain elusive. Here, we describe and characterize a novel gene-modified mouse model for an inducible and specific Cre/Lox-media...
Source: American Journal of Physiology. Renal Physiology - March 9, 2023 Category: Physiology Authors: Laurent Bourqui Denise V Winter Alex Odermatt Dominique Loffing-Cueni Johannes Loffing Source Type: research
A novel mouse model for an inducible gene-modification in the renal thick ascending limb
Am J Physiol Renal Physiol. 2023 Mar 9. doi: 10.1152/ajprenal.00250.2022. Online ahead of print.ABSTRACTThe thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant in the luminal membrane of TAL cells. TAL function is regulated by various hormonal and non-hormonal factors. However, many of the underlying signal transduction pathways remain elusive. Here, we describe and characterize a novel gene-modified mouse model for an inducible and specific Cre/Lox-media...
Source: Am J Physiol Renal P... - March 9, 2023 Category: Urology & Nephrology Authors: Laurent Bourqui Denise V Winter Alex Odermatt Dominique Loffing-Cueni Johannes Loffing Source Type: research
A novel mouse model for an inducible gene-modification in the renal thick ascending limb
Am J Physiol Renal Physiol. 2023 Mar 9. doi: 10.1152/ajprenal.00250.2022. Online ahead of print.ABSTRACTThe thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant in the luminal membrane of TAL cells. TAL function is regulated by various hormonal and non-hormonal factors. However, many of the underlying signal transduction pathways remain elusive. Here, we describe and characterize a novel gene-modified mouse model for an inducible and specific Cre/Lox-media...
Source: American Journal of Physiology. Renal Physiology - March 9, 2023 Category: Physiology Authors: Laurent Bourqui Denise V Winter Alex Odermatt Dominique Loffing-Cueni Johannes Loffing Source Type: research
A novel mouse model for an inducible gene-modification in the renal thick ascending limb
Am J Physiol Renal Physiol. 2023 Mar 9. doi: 10.1152/ajprenal.00250.2022. Online ahead of print.ABSTRACTThe thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant in the luminal membrane of TAL cells. TAL function is regulated by various hormonal and non-hormonal factors. However, many of the underlying signal transduction pathways remain elusive. Here, we describe and characterize a novel gene-modified mouse model for an inducible and specific Cre/Lox-media...
Source: Am J Physiol Renal P... - March 9, 2023 Category: Urology & Nephrology Authors: Laurent Bourqui Denise V Winter Alex Odermatt Dominique Loffing-Cueni Johannes Loffing Source Type: research
