Preclinical investigations on broccoli-derived sulforaphane for the treatment of ophthalmic disease
Drug Discov Today. 2023 Jul 17:103718. doi: 10.1016/j.drudis.2023.103718. Online ahead of print.ABSTRACTVision loss causes a significant burden on individuals and communities on a financial, emotional and social level. Common causes include age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma and retinitis pigmentosa (RP; also known as 'rod-cone dystrophy'). As the population continues to grow and age globally, an increasing number of people will experience vision loss. Hence, there is an urgent need to develop therapies that can curb early pathological events. The broccoli-derived compound, sulforap...
Source: Drug Discovery Today - July 19, 2023 Category: Drugs & Pharmacology Authors: Faith A A Kwa Bang V Bui Bruce R Thompson Lauren N Ayton Source Type: research
Preclinical investigations on broccoli-derived sulforaphane for the treatment of ophthalmic disease
Drug Discov Today. 2023 Jul 17;28(9):103718. doi: 10.1016/j.drudis.2023.103718. Online ahead of print.ABSTRACTVision loss causes a significant burden on individuals and communities on a financial, emotional and social level. Common causes include age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma and retinitis pigmentosa (RP; also known as 'rod-cone dystrophy'). As the population continues to grow and age globally, an increasing number of people will experience vision loss. Hence, there is an urgent need to develop therapies that can curb early pathological events. The broccoli-derived compound, su...
Source: Drug Discovery Today - July 19, 2023 Category: Drugs & Pharmacology Authors: Faith A A Kwa Bang V Bui Bruce R Thompson Lauren N Ayton Source Type: research
The current status, challenges, and future perspectives for managing diseases of brassicas
The Brassica genus comprises the greatest diversity of agriculturally important crops. Several species from this genus are grown as vegetable and oil crops for food, animal feed and industrial purposes. In particular, B. oleracea has been extensively bred to give rise to several familiar vegetables (cabbage, broccoli, cauliflower, kale and Brussels Sprouts, etc.) that are grouped under seven major cultivars. In 2020, 96.4 million tonnes of vegetable brassicas were produced globally with a 10.6% increase over the past decade. Yet, like other crops, the production of brassicas is challenged by diseases among which, black rot...
Source: Frontiers in Microbiology - July 18, 2023 Category: Microbiology Source Type: research
Fruit and vegetable consumption and the risk of hypertension: a systematic review and meta-analysis of prospective studies
ConclusionA high intake of fruit and vegetables combined, and total fruit was associated with reduced risk of hypertension, while results for fruit and vegetable subtypes were mixed and need further study. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - July 15, 2023 Category: Nutrition Source Type: research
Multi-omic analysis of the extension of broccoli quality during storage by folic acid
CONCLUSIONS: FA treatment inhibited the loss of nutrients during the storage of broccoli, delayed its yellowing, and inhibited the generation of off-odors. Our study provides deeper insight into the mechanism by which the postharvest application of FA delays postharvest senescence in broccoli and provides the foundation for further studies of postharvest metabolism in broccoli.PMID:37406731 | DOI:10.1016/j.jare.2023.07.001 (Source: Adv Data)
Source: Adv Data - July 5, 2023 Category: Epidemiology Authors: Yaqi Zhao Junyan Shi Bihong Feng Shuzhi Yuan Xiaozhen Yue Wenlin Shi Zhicheng Yan Dongying Xu Jinhua Zuo Qing Wang Source Type: research
Molecules, Vol. 28, Pages 5080: Exploring the Potential of Broadband Complementary Metal Oxide Semiconductor Micro-Coil Nuclear Magnetic Resonance for Environmental Research
A. Colnago
Andre J. Simpson
With sensitivity being the Achilles’ heel of nuclear magnetic resonance (NMR), the superior mass sensitivity offered by micro-coils can be an excellent choice for tiny, mass limited samples such as eggs and small organisms. Recently, complementary metal oxide semiconductor (CMOS)-based micro-coil transceivers have been reported and demonstrate excellent mass sensitivity. However, the ability of broadband CMOS micro-coils to study heteronuclei has yet to be investigated, and here their potential is explored within the lens of environmental research. Eleven nuclei including 7Li...
Source: Molecules - June 29, 2023 Category: Chemistry Authors: Daniel H. Lysak Marco Grisi Kathryn Marable Gaurasundar M. Conley Carl A. Michal Vincent Moxley-Paquette William W. Wolff Katelyn Downey Flavio V. C. Kock Peter M. Costa Kiera Ronda Tiago B. Moraes Katrina Steiner Luiz A. Colnago Andre J. Simpson Tags: Article Source Type: research
Sensors, Vol. 23, Pages 5937: Determining the Nutrient Content of Hydroponically-Cultivated Microgreens with Immersible Silicon Photonic Sensors: A Preliminary Feasibility Study
akos
Eleni Makarona
Microgreens have gained attention for their exceptional culinary characteristics and high nutritional value. The present study focused on a novel approach for investigating the easy extraction of plant samples and the utilization of immersible silicon photonic sensors to determine, on the spot, the nutrient content of microgreens and their optimum time of harvest. For the first time, it was examined how these novel sensors can capture time-shifting spectra caused by the molecules’ dynamic adhesion onto the sensor surface. The experiment involved four types of microgreens (three types...
Source: Sensors - June 26, 2023 Category: Biotechnology Authors: Aristi Christofi Georgia Margariti Alexandros Salapatas George Papageorgiou Panagiotis Zervas Pythagoras Karampiperis Antonis Koukourikos Petros A. Tarantilis Eleftheria H. Kaparakou Konstantinos Misiakos Eleni Makarona Tags: Article Source Type: research
Genes, Vol. 14, Pages 1307: Identification and Characterization of Novel SPHINX/BMMF-like DNA Sequences Isolated from Non-Bovine Foods
Franz
Sixteen novel circular rep-encoding DNA sequences with high sequence homologies to previously described SPHINX and BMMF sequences were isolated for the first time from non-bovine foods (pork, wild boar, chicken meat, Alaska pollock, pangasius, black tiger shrimp, apple, carrot, and sprouts from alfalfa, radish, and broccoli). The phylogenetic analysis of the full-length circular genomes grouped these together with previously described representatives of SPHINX/BMMF group 1 and 2 sequences (eight in each group). The characterization of genome lengths, genes present, and conserved structures confirmed their relatio...
Source: Genes - June 21, 2023 Category: Genetics & Stem Cells Authors: Diana Habermann Martin Klempt Charles M. A. P. Franz Tags: Article Source Type: research
Urinary 2- to 16 α-hydroxyestrone ratio did not change with cruciferous vegetable intake in premenopausal women
In conclusion, neither cruciferous supplements nor an added vegetable serving altered urinary 2:16 in premenopausal women with eight weeks treatment. This ratio did vary with time, which is important for designing future trials.PMID:37335576 | DOI:10.1024/0300-9831/a000785 (Source: International Journal for Vitamin and Nutrition Research)
Source: International Journal for Vitamin and Nutrition Research - June 19, 2023 Category: Nutrition Authors: Stephanie J Davis Sara A Arscott Shellen Goltz Cassidy Muir Neil Binkley Sherry A Tanumihardjo Source Type: research
