Molecules, Vol. 28, Pages 5080: Exploring the Potential of Broadband Complementary Metal Oxide Semiconductor Micro-Coil Nuclear Magnetic Resonance for Environmental Research

Molecules, Vol. 28, Pages 5080: Exploring the Potential of Broadband Complementary Metal Oxide Semiconductor Micro-Coil Nuclear Magnetic Resonance for Environmental Research Molecules doi: 10.3390/molecules28135080 Authors: Daniel H. Lysak Marco Grisi Kathryn Marable Gaurasundar M. Conley Carl A. Michal Vincent Moxley-Paquette William W. Wolff Katelyn Downey Flavio V. C. Kock Peter M. Costa Kiera Ronda Tiago B. Moraes Katrina Steiner Luiz A. Colnago Andre J. Simpson With sensitivity being the Achilles’ heel of nuclear magnetic resonance (NMR), the superior mass sensitivity offered by micro-coils can be an excellent choice for tiny, mass limited samples such as eggs and small organisms. Recently, complementary metal oxide semiconductor (CMOS)-based micro-coil transceivers have been reported and demonstrate excellent mass sensitivity. However, the ability of broadband CMOS micro-coils to study heteronuclei has yet to be investigated, and here their potential is explored within the lens of environmental research. Eleven nuclei including 7Li, 19F, 31P and, 205Tl were studied and detection limits in the low to mid picomole range were found for an extended experiment. Further, two environmentally relevant samples (a sprouting broccoli seed and a D. magna egg) were successfully studied using the CMOS micro-coil system. 13C NMR was used to help resolve broad signals in the 1H spectrum of the 13C enriched broccoli seed, and steady stat...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research