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Comparison of clinical characteristics between ACOSOG Z0011-eligible cohort and sentinel lymph node-positive breast cancer patients in Hong Kong
CONCLUSION: This study demonstrated that clinicopathological features were comparable between SLN-positive breast cancer patients undergoing mastectomy and those undergoing breast-conserving treatment. Low-risk SLN-positive mastectomy patients may safely avoid completion axillary lymph node dissection.PMID:38523397 | DOI:10.12809/hkmj2210286 (Source: Hong Kong Med J)
Source: Hong Kong Med J - March 25, 2024 Category: General Medicine Authors: V Man A Kwong Source Type: research

Correction: Contemporary Analysis of Reexcision and Conversion to Mastectomy Rates and Associated Healthcare Costs for Women Undergoing Breast-Conserving Surgery
Ann Surg Oncol. 2024 Mar 23. doi: 10.1245/s10434-024-15212-0. Online ahead of print.NO ABSTRACTPMID:38520584 | DOI:10.1245/s10434-024-15212-0 (Source: Ann Oncol)
Source: Ann Oncol - March 23, 2024 Category: Cancer & Oncology Authors: Youngran Kim Cecilia Ganduglia-Cazaban Nina Tamirisa Anthony Lucci Trudy Millard Krause Source Type: research

Clinicopathological Predictors of Positive Resection Margins in Breast-Conserving Surgery
CONCLUSIONS: Compared with pure IBC, the relative risk of a positive margin with IBC + DCIS is approximately ninefold, significantly higher than prior estimates. This margin-level methodology is believed to represent the impact of DCIS more accurately on margin positivity in IBC.PMID:38520579 | DOI:10.1245/s10434-024-15153-8 (Source: Ann Oncol)
Source: Ann Oncol - March 23, 2024 Category: Cancer & Oncology Authors: Hemali Chauhan Natasha Jiwa Vikneswaran Raj Nagarajan Paul Thiruchelvam Katy Hogben Ragheed Al-Mufti Dimitri Hadjiminas Sami Shousha Ramsey Cutress Hutan Ashrafian Zoltan Takats Daniel Richard Leff Source Type: research

A Systematic Review and Meta-analysis of the Role of Preoperative MRI in In-breast Tumor Recurrence After Breast-Conserving Surgery
CONCLUSIONS: Although some evidence supports the hypothesis that identification of additional tumors in the breast using pMRI results in lower rates of IBTR after BCS, the main meta-analysis in this study did not confirm this hypothesis.PMID:38520578 | DOI:10.1245/s10434-023-14746-z (Source: Ann Oncol)
Source: Ann Oncol - March 23, 2024 Category: Cancer & Oncology Authors: Matthew C Carroll Renata W Yen Mary Leech Richard J Barth Source Type: research

Outcomes of reconstructive techniques in breast cancer using BCCT. core software
This study aimed to compare the cosmetic outcomes of oncoplastic patients who had undergone breast-conserving surgery, mini-LDF (latissimus dorsi flap), ... (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - March 23, 2024 Category: Cancer & Oncology Authors: Sevgi Kurt, Ahmet Serkan İlgün, Enver Özkurt, Gürsel Soybir, Gül Alço, Çağlar Ünal, Filiz Elbüken Çelebi, Tomris Duymaz, Tuğba Kayan Tapan, Naziye Ak, Çetin Ordu and Vahit Özmen Tags: Methodology Source Type: research

Inhibition of breast cancer cell growth and migration through siRNA-mediated modulation of circ_0009910/miR-145-5p/MUC1 axis
Noncoding RNA Res. 2024 Jan 26;9(2):367-375. doi: 10.1016/j.ncrna.2024.01.016. eCollection 2024 Jun.ABSTRACTCircular RNAs (circRNAs) characterize a novel kind of regulatory RNAs distinguished by great evolutionary conservation and constancy. Although their exact role in malignancies is not fully understood, they mainly work through specific axes. Circular RNA/miRNA/mRNA axes affect the pathogenesis of human cancers including breast cancer. We assessed the expression and function of circ_0009910/miR-145-5p/MUC1 axis in Breast Cancer tissues and MCF-7 cells. Expression levels of circ_0009910 and MUC1 were notably increased i...
Source: Cell Research - March 21, 2024 Category: Cytology Authors: Maryam Abtin Nahid Nafisi Asghar Hosseinzadeh Sepideh Kadkhoda Ramesh Omranipour Leyla Sahebi Masoumeh Razipour Soudeh Ghafouri-Fard Abbas Shakoori Source Type: research

Comparative study of weekly and three-weekly neoadjuvant carboplatin in triple-negative breast cancer: retrospective analysis in real-world settings
CONCLUSIONS: Weekly carboplatin exhibited comparable toxicity, a trend toward fewer interruptions, and similar pCR rates. Prospective studies are essential for validating these findings.PMID:38509430 | DOI:10.1007/s12094-024-03430-7 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Ana Isabel Martin-Quesada Elisenda Llabres-Valent í Cristina Mar ía Montesdeoca-Godoy Carla Mart ín-Abreu Cristina Alem án-Sánchez Natalia Rodr íguez-Pérez Alicia Herrero-M árquez Josefina Cruz-Jurado Mar ía Hernández-Sosa Melody Marrero-Garc í Source Type: research

Comparative study of weekly and three-weekly neoadjuvant carboplatin in triple-negative breast cancer: retrospective analysis in real-world settings
CONCLUSIONS: Weekly carboplatin exhibited comparable toxicity, a trend toward fewer interruptions, and similar pCR rates. Prospective studies are essential for validating these findings.PMID:38509430 | DOI:10.1007/s12094-024-03430-7 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Ana Isabel Martin-Quesada Elisenda Llabres-Valent í Cristina Mar ía Montesdeoca-Godoy Carla Mart ín-Abreu Cristina Alem án-Sánchez Natalia Rodr íguez-Pérez Alicia Herrero-M árquez Josefina Cruz-Jurado Mar ía Hernández-Sosa Melody Marrero-Garc í Source Type: research

Inhibition of breast cancer cell growth and migration through siRNA-mediated modulation of circ_0009910/miR-145-5p/MUC1 axis
Noncoding RNA Res. 2024 Jan 26;9(2):367-375. doi: 10.1016/j.ncrna.2024.01.016. eCollection 2024 Jun.ABSTRACTCircular RNAs (circRNAs) characterize a novel kind of regulatory RNAs distinguished by great evolutionary conservation and constancy. Although their exact role in malignancies is not fully understood, they mainly work through specific axes. Circular RNA/miRNA/mRNA axes affect the pathogenesis of human cancers including breast cancer. We assessed the expression and function of circ_0009910/miR-145-5p/MUC1 axis in Breast Cancer tissues and MCF-7 cells. Expression levels of circ_0009910 and MUC1 were notably increased i...
Source: Cancer Control - March 21, 2024 Category: Cancer & Oncology Authors: Maryam Abtin Nahid Nafisi Asghar Hosseinzadeh Sepideh Kadkhoda Ramesh Omranipour Leyla Sahebi Masoumeh Razipour Soudeh Ghafouri-Fard Abbas Shakoori Source Type: research

Comparative study of weekly and three-weekly neoadjuvant carboplatin in triple-negative breast cancer: retrospective analysis in real-world settings
CONCLUSIONS: Weekly carboplatin exhibited comparable toxicity, a trend toward fewer interruptions, and similar pCR rates. Prospective studies are essential for validating these findings.PMID:38509430 | DOI:10.1007/s12094-024-03430-7 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Ana Isabel Martin-Quesada Elisenda Llabres-Valent í Cristina Mar ía Montesdeoca-Godoy Carla Mart ín-Abreu Cristina Alem án-Sánchez Natalia Rodr íguez-Pérez Alicia Herrero-M árquez Josefina Cruz-Jurado Mar ía Hernández-Sosa Melody Marrero-Garc í Source Type: research

Changes in Radiation Therapy: New Ultrahypofractionated Radiation, Repeat Breast Conservation Therapy in the Management of Breast Recurrence with Re-irradiation, Proton Therapy
AbstractPurpose of ReviewManagement of breast cancer is multidisciplinary, balancing local and systemic control between treatment modalities. Surgical, radiation, and medical therapies are combined to give the best prognosis. The goal of this review is to examine the advancements in radiotherapy in the treatment of breast cancer.Recent FindingsPublished data supports the shortening of radiation schedules through ultrahypofractionation and utilizing new energy sources through proton beam radiation. Emerging techniques have minimized radiation dosage to organs at risk and skin when compared to traditional radiation sources a...
Source: Current Breast Cancer Reports - March 21, 2024 Category: Cancer & Oncology Source Type: research