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Personalized Radiation Therapy for Breast Cancer
Curr Oncol. 2024 Mar 20;31(3):1588-1599. doi: 10.3390/curroncol31030121.ABSTRACTBreast cancer is diagnosed in nearly 3 million people worldwide. Radiation therapy is an integral component of disease management for patients with breast cancer, and is used after breast-conserving surgery or a mastectomy to reduce the risk of a local recurrence. The following review describes the methods used to personalize radiation therapy by optimizing patient selection, using advanced treatment techniques to lessen the radiation dose to normal organs, and using hypofractionation in order to shorten the duration of radiation treatment.PMID...
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Waqar Haque Edward Brian Butler Bin S Teh Source Type: research

The Role of Adjuvant Radiotherapy in the Treatment of Breast Cancer
Curr Oncol. 2024 Feb 24;31(3):1207-1220. doi: 10.3390/curroncol31030090.ABSTRACTThe role of postmastectomy radiotherapy and regional nodal irradiation after radical mastectomy is defined in high-risk patients with locally advanced tumors, positive margins, and unfavorable biology. The benefit of postmastectomy radiotherapy in intermediate-risk patients (T3N0 tumors) remains a matter of controversy. It has been demonstrated that radiotherapy after breast-conserving surgery lowers the locoregional recurrence rate compared with surgery alone and improves the overall survival rate. In patients with four or more positive lymph ...
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Iveta Kol ářová Bohuslav Melichar Igor Sir ák Jaroslav Va ňásek Ji ří Petera Kate řina Horáčková Denisa Pohankov á Filip Ďatelinka Zuzana Šinkorová Milan Vo šmik Source Type: research

Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Neoplasia. 2024 Mar 26;51:100989. doi: 10.1016/j.neo.2024.100989. Online ahead of print.ABSTRACTGene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber Pakhtunkhwa. To determine the BRCA1 and BRCA2 pathogenic mutation prevalence in Pakhtun population from KP, whole exome sequenci...
Source: Neoplasia - March 27, 2024 Category: Cancer & Oncology Authors: Hilal Ahmad Asif Ali Roshan Ali Ali Talha Khalil Ishaq Khan Mah Muneer Khan Mohammed Alorini Source Type: research