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Systemic Therapy Advances for HER2-Positive and Triple Negative Breast Cancer: What the Surgeon Needs to Know
Clin Breast Cancer. 2024 Mar 13:S1526-8209(24)00077-6. doi: 10.1016/j.clbc.2024.03.004. Online ahead of print.ABSTRACTNeoadjuvant systemic therapy (NST) was initially reserved for unresectable patients however it has been increasingly used to facilitate breast conservation, downstage the axilla, and inform adjuvant therapy decisions based on response. For patients with HER2+ and triple-negative breast cancer (TNBC), clinical trials have resulted in the ability to individualize treatment regimens. For HER2+ breast cancer, de-escalation of neoadjuvant regimens to minimize cytotoxic chemotherapy and de-escalation or escalatio...
Source: Clinical Breast Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Stephanie Downs-Canner Anna Weiss Source Type: research

Systemic Therapy Advances for HER2-Positive and Triple Negative Breast Cancer: What the Surgeon Needs to Know
Clin Breast Cancer. 2024 Mar 13:S1526-8209(24)00077-6. doi: 10.1016/j.clbc.2024.03.004. Online ahead of print.ABSTRACTNeoadjuvant systemic therapy (NST) was initially reserved for unresectable patients however it has been increasingly used to facilitate breast conservation, downstage the axilla, and inform adjuvant therapy decisions based on response. For patients with HER2+ and triple-negative breast cancer (TNBC), clinical trials have resulted in the ability to individualize treatment regimens. For HER2+ breast cancer, de-escalation of neoadjuvant regimens to minimize cytotoxic chemotherapy and de-escalation or escalatio...
Source: Clinical Genitourinary Cancer - April 15, 2024 Category: Cancer & Oncology Authors: Stephanie Downs-Canner Anna Weiss Source Type: research

Nipple-Sparing Mastectomy and Adequate Margins for Patients With Ductal Carcinoma In Situ
DISCUSSION: No specific margin status was found to correlate with recurrence for patients with DCIS or DCIS + MI undergoing NSM, with an altogether low recurrence risk. Overall, this suggests that recommended DCIS margins in BCS doesn't necessarily apply in NSM, where margins of <2 mm may be acceptable.PMID:38605446 | DOI:10.1177/00031348241246179 (Source: The American Surgeon)
Source: The American Surgeon - April 12, 2024 Category: Surgery Authors: Kristina Shaffer Lilian Harris Stephanie Ng Judy A Tjoe Source Type: research

The value of oestrogen receptor, progesterone receptor and keratins 5 and 14 immunohistochemistry in the evaluation of epithelial proliferations at cauterised margins in breast-conserving surgery specimens
Pathol Res Pract. 2024 Apr 1;257:155280. doi: 10.1016/j.prp.2024.155280. Online ahead of print.ABSTRACTIn breast conservative surgery, it is sometimes difficult to decide whether the cauterised tissue at the inked margin represents normal / hyperplastic or neoplastic tissue. We retrospectively assessed the value of ER, PR, CK5 and CK14 IHC in clarifying the nature of cauterised tissues at the margins concerning 34 lesions of 23 patients. 27 cases belonged to lesions that could not be adequately classified on the basis of the HE stains. Two thirds of them could be classified as non-neoplastic or neoplastic and two thirds of...
Source: Cell Research - April 12, 2024 Category: Cytology Authors: Szintia Alm ási G ábor Cserni Source Type: research

Acute adverse events of ultra-hypofractionated whole-breast irradiation after breast-conserving surgery for early breast cancer in Japan: an interim analysis of the multi-institutional phase II UPBEAT study
CONCLUSIONS: Acute AEs following ultra-HF-WBI were within acceptable limits among Japanese women, indicating that the continuation of the study was appropriate.PMID:38607499 | DOI:10.1007/s12282-024-01577-3 (Source: Breast Cancer)
Source: Breast Cancer - April 12, 2024 Category: Cancer & Oncology Authors: Peter J K Tokuda Takamasa Mitsuyoshi Yuka Ono Takahiro Kishi Yoshiharu Negoro Setsuko Okumura Itaru Ikeda Takashi Sakamoto Yumi Kokubo Ryo Ashida Toshiyuki Imagumbai Mikiko Yamashita Hiroaki Tanabe Sayaka Takebe Mariko Tokiwa Eiji Suzuki Chikako Yamauchi Source Type: research

The value of oestrogen receptor, progesterone receptor and keratins 5 and 14 immunohistochemistry in the evaluation of epithelial proliferations at cauterised margins in breast-conserving surgery specimens
Pathol Res Pract. 2024 Apr 1;257:155280. doi: 10.1016/j.prp.2024.155280. Online ahead of print.ABSTRACTIn breast conservative surgery, it is sometimes difficult to decide whether the cauterised tissue at the inked margin represents normal / hyperplastic or neoplastic tissue. We retrospectively assessed the value of ER, PR, CK5 and CK14 IHC in clarifying the nature of cauterised tissues at the margins concerning 34 lesions of 23 patients. 27 cases belonged to lesions that could not be adequately classified on the basis of the HE stains. Two thirds of them could be classified as non-neoplastic or neoplastic and two thirds of...
Source: Pathology, Research and Practice - April 12, 2024 Category: Pathology Authors: Szintia Alm ási G ábor Cserni Source Type: research

Radiological, pathological and surgical outcomes after neoadjuvant endocrine treatment in patients with ER-positive/HER2-negative breast cancer with a clinical high risk and a low-risk 70-gene signature
CONCLUSION: The study showed that a subgroup of patients with a clinical high risk and a genomic low risk ER+/HER2-breast cancer benefits from NET resulting in BCS instead of a mastectomy. Additionally, NET may enable de-escalation in axillary treatment.PMID:38599047 | DOI:10.1016/j.breast.2024.103726 (Source: Breast)
Source: Breast - April 10, 2024 Category: Cancer & Oncology Authors: Josefien P van Olmen Chaja F Jacobs Sanne A L Bartels Claudette E Loo Joyce Sanders Marie-Jeanne T F D Vrancken Peeters Caroline A Drukker Frederieke H van Duijnhoven Marleen Kok Source Type: research

De-escalation of axillary treatment in the event of a positive sentinel lymph node biopsy in cT1-2 N0 breast cancer treated with mastectomy: nationwide registry study (BOOG 2013-07)
CONCLUSION: In this registry study of patients with cT1-2 N0 breast cancer treated with mastectomy, with low-volume sentinel lymph node metastasis, the 5-year regional recurrence rate was low and comparable between patients with and without completion axillary treatment.PMID:38597154 | PMC:PMC11004788 | DOI:10.1093/bjs/znae077 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - April 10, 2024 Category: Surgery Authors: Sabine R de Wild Lori M van Roozendaal Johannes H W de Wilt Thijs van Dalen Jos A van der Hage Frederieke H van Duijnhoven Janine M Simons Robert-Jan Schipper Linda de Munck Sander M J van Kuijk Liesbeth J Boersma Sabine C Linn Marc B I Lobbes Philip M P Source Type: research

Quantifying radiation-induced breast fibrosis by shear-wave elastography in patients with breast cancer: A 12-months-follow-up data of a prospective study
CONCLUSION: We demonstrated that SWE enables the evaluation of tissue stiffness to provide quantified information for the RIF of breast cancer. Further studies with long-term follow-up should provide more quantitative data.PMID:38590328 | PMC:PMC10999491 | DOI:10.1016/j.ctro.2024.100773 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Wonguen Jung Jin Chung Jihae Lee Kyubo Kim Source Type: research