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Seromucinous Tumors of the Ovary. What’s in a Name?
The recent 2014 World Health Organization (WHO) Classification of Tumours of the Female Reproductive Organs introduced a new category of ovarian neoplasm designated “seromucinous tumours”. The recognition of this distinctive group of tumors is an important addition to the classification but the term “seromucinous” has serious flaws that obscures the nature of these neoplasms. Morphologically, seromucinous tumors in addition to serous and endocervical-type mucinous epithelium, contain endometrioid, indifferent and squamous type epithelium. Their immunoprofile is characterized by frequent expression of ER, PR, infreq...
Source: International Journal of Gynecological Pathology - December 8, 2015 Category: Pathology Tags: Pathology of the Upper Genital Tract: Review Source Type: research

Molecular Alterations of TP53 are a Defining Feature of Ovarian High-Grade Serous Carcinoma: A Rereview of Cases Lacking TP53 Mutations in The Cancer Genome Atlas Ovarian Study
The Cancer Genome Atlas has reported that 96% of ovarian high-grade serous carcinomas (HGSCs) have TP53 somatic mutations suggesting that mutation of this gene is a defining feature of this neoplasm. In the current study, 5 gynecologic pathologists independently evaluated hematoxylin and eosin slides of 14 available cases from The Cancer Genome Atlas classified as HGSC that lacked a TP53 mutation. The histologic diagnoses rendered by these pathologists and the accompanying molecular genetic data are the subject of this report. Only 1 case (Case 5), which contained a homozygous deletion of TP53, had unanimous interobserver ...
Source: International Journal of Gynecological Pathology - December 8, 2015 Category: Pathology Tags: Pathology of the Upper Genital Tract: Original Articles Source Type: research

Prevalence of Endometriosis in Malignant Epithelial Ovarian Tumor.
CONCLUSION: Clear cell and endometrioid carcinoma are the most common types of EACO. Atypical endometriosis was more commonly seen in endometrioid and clear cell carcinomas which are included in type I ovarian cancer. Thus, it can be concluded that atypical endometriosis is a precursor for type I ovarian cancer. PMID: 26621017 [PubMed - in process] (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - December 1, 2015 Category: Middle East Health Authors: Akbarzadeh-Jahromi M, Shekarkhar G, Sari Aslani F, Azarpira N, Heidari Esfahani M, Momtahan M Tags: Arch Iran Med Source Type: research

[Metastatic tumors of the ovary].
We examined 152 cases of secondary ovarian neoplasm diagnosed at the National Institute of Oncology, Hungary from 2000 to 2014. Colorectal cancer was the most common primary tumor (58 cases), followed by breast (33 cases), endometrium (30 cases) and stomach cancer (13 cases). The differential diagnosis proved the most difficult in cases when endometrioid and mucinous tumors were presented in the ovaries. Metastases of colorectal and gastric adenocarcinomas may simulate benign or borderline cystadenomas too. In these cases the knowledge of the patient's history and immunohistochemical stains were helpful. In our study we di...
Source: Magyar Onkologia - September 4, 2015 Category: Cancer & Oncology Authors: Tamás J, Vereczkey I, Tóth E Tags: Magy Onkol Source Type: research

Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in patients with ovarian tumors.
CONCLUSIONS: LAT1 is highly expressed in various ovarian tumors and a positive LAT1 expression can serve as a significant independent factor for predicting a poor OS in patients with epidermal ovarian cancer. PMID: 26279759 [PubMed] (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - August 22, 2015 Category: Research Tags: Am J Transl Res Source Type: research

Reactivity of CA19-9 and CA125 in Histological Subtypes of Epithelial Ovarian Tumors and Ovarian Endometriosis.
We examined the relationship between the staging and histological subtypes of OE or epithelial ovarian tumors (EOT) and the serum levels of carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 125 (CA125) to evaluate the potential of these markers for preoperative diagnosis. First, we analyzed the preoperative serum levels of CA19-9 and CA125 in 195 patients who were histopathologically diagnosed with OE or EOT. We then performed a case-control study in which 308 women were enrolled, the 195 women described above and 113 healthy women as control subjects. Serum CA19-9 and CA125 levels were found to be useful in diff...
Source: Acta Med Okayama - August 1, 2015 Category: Universities & Medical Training Authors: Nakagawa N, Koda H, Nitta N, Nakahara Y, Uno J, Hashimoto T, Nakahori T, Hasegawa M, Kataoka M Tags: Acta Med Okayama Source Type: research

Ovarian Seromucinous Carcinoma: Report of a Series of a Newly Categorized and Uncommon Neoplasm
We report the clinicopathologic features in 19 cases of ovarian seromucinous carcinoma in patients aged 16 to 79 years (mean 47). In 16 cases, the neoplasm was unilateral and in 3 cases bilateral. The tumors ranged in size from 1.8 to 18 cm (mean 10.5 cm). The tumors were stage I (n=15), stage II (n=1), and stage III (n=3). The histologic features were highly variable both within and between individual tumors. The majority of neoplasms (12 cases) exhibited a predominant papillary architecture with lesser components of glandular, microglandular, and solid growth. A predominant glandular architecture was present in 6 cases, ...
Source: The American Journal of Surgical Pathology - June 16, 2015 Category: Pathology Tags: Original Articles Source Type: research

New insights in the pathophysiology of ovarian cancer and implications for screening and prevention
Despite advances in medicine, ovarian cancer remains the deadliest of the gynecologic malignancies. Herein, we present the latest information on the pathophysiology of ovarian cancer and its significance for ovarian cancer screening and prevention. A new paradigm for ovarian cancer pathogenesis presupposes two distinct types of ovarian epithelial carcinoma with distinct molecular profiles: Type I and Type II carcinomas. Type I tumors include endometrioid, clear cell carcinoma, and low grade serous carcinoma and mostly arise via defined sequence either from endometriosis or from borderline serous tumors, mostly presenting i...
Source: American Journal of Obstetrics and Gynecology - March 26, 2015 Category: OBGYN Authors: Farr R. Nezhat, Radu Apostol, Camran Nezhat, Tanja Pejovic Source Type: research

Incidental Nonuterine High-grade Serous Carcinomas Arise in the Fallopian Tube in Most Cases: Further Evidence for the Tubal Origin of High-grade Serous Carcinomas
Most nonuterine high-grade serous carcinomas (HGSCs) in women with hereditary breast and ovarian cancer syndrome, due to germline BRCA1/2 mutation, arise in the fimbria of the fallopian tube. However, the site of origin of sporadic HGSC, which is usually widely disseminated at presentation, is not well established. We sought to characterize cases of HGSC discovered incidentally in patients not known to be at high risk, in order to determine the site distribution and possible origin of sporadic HGSC. Incidental microscopic, non–mass-forming cases of serous tubal intraepithelial carcinoma or HGSC in salpingo-oophorectomy s...
Source: The American Journal of Surgical Pathology - February 14, 2015 Category: Pathology Tags: Original Articles Source Type: research

Reproductive and hormone‐related risk factors for epithelial ovarian cancer by histologic pathways, invasiveness, and histologic subtypes: Results from the EPIC cohort
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - February 5, 2015 Category: Cancer & Oncology Authors: Renée T. Fortner, Jennifer Ose, Melissa A. Merritt, Helena Schock, Anne Tj⊘nneland, Louise Hansen, Kim Overvad, Laure Dossus, Françoise Clavel‐Chapelon, Laura Baglietto, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Pagona Lagiou,, Claudia Tags: Research Article Source Type: research

Tubal Ligation and Salpingectomy and the Risk of Epithelial Ovarian Cancer and Borderline Ovarian Tumors: A Nationwide Case-Control Study
ABSTRACT: It was long believed that epithelial cancer originated in the ovarian surface epithelium. Recent studies, however, have shown that its origin is extraovarian, with tumor cells subsequently migrating to the ovary. Current theories on origin of ovarian cancer histologic subtypes suggest that serous tumors develop from the fallopian tube, whereas endometrioid and clear cell tumors originate from the endometrium. If tubal ligation prevents the migration of endometrial tissue through the fallopian tube, the largest risk reduction could be expected for endometrioid and clear cell ovarian cancers. Two meta-analyses and ...
Source: Obstetrical and Gynecological Survey - February 1, 2015 Category: OBGYN Tags: Gynecology: Operative Gynecology Source Type: research

Epithelial Ovarian Cancers and Endometriosis
Conclusions: There is a significant association between endometriosis, including atypical forms, and endometrioid and clear cell carcinomas, but not with other EOC histotypes. The presence of endometriosis in EOC suggests a better prognosis and an intermediate stage within the progression endometriosis-carcinoma.Gynecol Obstet Invest (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - January 26, 2015 Category: OBGYN Source Type: research

Incidence of Serous Tubal Intraepithelial Carcinoma (STIC) by Algorithm Classification in Serous Ovarian Tumor Associated with PAX8 Expression in Tubal Epithelia: A Study of Single Institution in Japan
Serous ovarian carcinoma is now hypothesized to originate from fallopian tube epithelium (FTE). We investigated the FTE abnormalities in the patients with epithelial ovarian tumors. Our study included 55 cases of serous tumors (24 carcinomas, 8 borderline tumors, and 23 adenomas), 14 mucinous carcinomas, 22 endometrioid carcinomas, 5 clear cell carcinomas, and 2 malignant Brenner tumors. FTE was diagnosed by the diagnostic algorithm, which combines the data of morphology, and p53, Ki-67 immunostaining, as serous tubal intraepithelial carcinoma, serous tubal intraepithelial lesion, p53 signature, and normal/reactive. Serous...
Source: International Journal of Gynecological Pathology - December 8, 2014 Category: Pathology Tags: Pathology of the Upper Genital Tract: Original Articles Source Type: research

Survival of women with ovarian carcinomas and borderline tumors is not affected by estrogen and progesterone receptor status.
CONCLUSION: Overall, serous and endometrioid tumors were predominantly ER/PR positive, whereas mucinous and clear-cell tumors were preponderantly ER/PR negative. DFS and OS were not affected by ER/PR expression. PMID: 23653835 [PubMed] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - December 2, 2014 Category: OBGYN Tags: J Gynecol Oncol Source Type: research

The lung-restricted marker napsin a is highly expressed in clear cell carcinomas of the ovary.
CONCLUSIONS: Our study showed that napsin A is an extremely sensitive (100%) marker of ovarian clear cell carcinomas and exhibits very high specificity (100%) in distinguishing clear cell carcinomas from high-grade serous carcinomas and serous borderline tumors and 90% specificity in discriminating clear cell carcinomas from endometrioid carcinomas. PMID: 25389337 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 16, 2014 Category: Pathology Authors: Kandalaft PL, Gown AM, Isacson C Tags: Am J Clin Pathol Source Type: research