Bacterial and mammalian F < sub > 1 < /sub > F < sub > O < /sub > -ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Int Rev Cell Mol Biol. 2023;377:45-63. doi: 10.1016/bs.ircmb.2023.01.006. Epub 2023 Feb 1.ABSTRACTThe inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However, small structural divergences distinguish prokaryotic ATP synthases, embedded in cell membranes, from eukaryotic ones localized in ...
Source: International Review of Cell and Molecular Biology - June 2, 2023 Category: Cytology Authors: Salvatore Nesci Source Type: research
Bacterial and mammalian F < sub > 1 < /sub > F < sub > O < /sub > -ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Int Rev Cell Mol Biol. 2023;377:45-63. doi: 10.1016/bs.ircmb.2023.01.006. Epub 2023 Feb 1.ABSTRACTThe inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However, small structural divergences distinguish prokaryotic ATP synthases, embedded in cell membranes, from eukaryotic ones localized in ...
Source: International Review of Cell and Molecular Biology - June 2, 2023 Category: Cytology Authors: Salvatore Nesci Source Type: research
Bacterial and mammalian F < sub > 1 < /sub > F < sub > O < /sub > -ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Int Rev Cell Mol Biol. 2023;377:45-63. doi: 10.1016/bs.ircmb.2023.01.006. Epub 2023 Feb 1.ABSTRACTThe inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However, small structural divergences distinguish prokaryotic ATP synthases, embedded in cell membranes, from eukaryotic ones localized in ...
Source: International Review of Cell and Molecular Biology - June 2, 2023 Category: Cytology Authors: Salvatore Nesci Source Type: research
EE316 Cost-Effectiveness of Pretomanid-Based Regimen for Treatment of Highly Drug-Resistant Tuberculosis in a High-Income Country
This study aimed to evaluate the cost-effectiveness of the pretomanid-based regimen for HDR-TB treatment from the perspective of healthcare provider in the US. (Source: Value in Health)
Source: Value in Health - June 1, 2023 Category: International Medicine & Public Health Authors: G. Fekadu, Y. Wang, J.H.S. You Source Type: research
Impact of anti-tuberculosis drug use on treatment outcomes in patients with pulmonary fluoroquinolone-resistant multidrug-resistant tuberculosis: A nationwide retrospective cohort study with propensity score matching
CONCLUSION: A therapeutic regimen guided by drug-susceptibility testing can improve the treatment of patients with pulmonary FQr-MDR-TB. In addition to core anti-TB drugs such as BDQ and LZD, treatment of susceptible strains with later-generation FQs and KM may be beneficial in FQr-MDR-TB patients with limited treatment options.PMID:37254489 | DOI:10.4046/trd.2023.0040 (Source: Respiratory Care)
Source: Respiratory Care - May 31, 2023 Category: Respiratory Medicine Authors: Hongjo Choi Dawoon Jeong Young Ae Kang Doosoo Jeon Hee-Yeon Kang Hee Jin Kim Hee-Sun Kim Jeongha Mok Source Type: research
Bedquiline Resistance Mutations: Correlations with Drug Exposures and Impact on the Proteome in M. tuberculosis
In conclusion, exposure to different bedaquiline concentrations resulted in the selection of different mutations. The coexpression of MmpL5 and MmpS5 contributed to drug resistance and upregulated pathogenic proteins in M. tuberculosis, suggesting MmpL5-MmpS5 as a new potential target for antituberculosis drug development. These results warrant further surveillance for the evolution of BDQ resistance during clinical usage.PMID:37255473 | DOI:10.1128/aac.01532-22 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - May 31, 2023 Category: Microbiology Authors: Jian Xu Dongshuo Li Jinghua Shi Bin Wang Fei Ge Zhenyong Guo Xiaopan Mu Eric Nuermberger Yu Lu Source Type: research
Impact of anti-tuberculosis drug use on treatment outcomes in patients with pulmonary fluoroquinolone-resistant multidrug-resistant tuberculosis: A nationwide retrospective cohort study with propensity score matching
CONCLUSION: A therapeutic regimen guided by drug-susceptibility testing can improve the treatment of patients with pulmonary FQr-MDR-TB. In addition to core anti-TB drugs such as BDQ and LZD, treatment of susceptible strains with later-generation FQs and KM may be beneficial in FQr-MDR-TB patients with limited treatment options.PMID:37254489 | DOI:10.4046/trd.2023.0040 (Source: Respiratory Care)
Source: Respiratory Care - May 31, 2023 Category: Respiratory Medicine Authors: Hongjo Choi Dawoon Jeong Young Ae Kang Doosoo Jeon Hee-Yeon Kang Hee Jin Kim Hee-Sun Kim Jeongha Mok Source Type: research
Inhibiting respiration as a novel antibiotic strategy
Curr Opin Microbiol. 2023 May 24;74:102327. doi: 10.1016/j.mib.2023.102327. Online ahead of print.ABSTRACTThe approval of the first-in-class antibacterial bedaquiline for tuberculosis marks a breakthrough in antituberculosis drug development. The drug inhibits mycobacterial respiration and represents the validation of a wholly different metabolic process as a druggable target space. In this review, we discuss the advances in the development of mycobacterial respiratory inhibitors, as well as the potential of applying this strategy to other pathogens. The non-fermentative nature of mycobacteria explains their vulnerability ...
Source: Current Opinion in Microbiology - May 26, 2023 Category: Microbiology Authors: Bei Shi Lee Samsher Singh Kevin Pethe Source Type: research
Inhibiting respiration as a novel antibiotic strategy
Curr Opin Microbiol. 2023 May 24;74:102327. doi: 10.1016/j.mib.2023.102327. Online ahead of print.ABSTRACTThe approval of the first-in-class antibacterial bedaquiline for tuberculosis marks a breakthrough in antituberculosis drug development. The drug inhibits mycobacterial respiration and represents the validation of a wholly different metabolic process as a druggable target space. In this review, we discuss the advances in the development of mycobacterial respiratory inhibitors, as well as the potential of applying this strategy to other pathogens. The non-fermentative nature of mycobacteria explains their vulnerability ...
Source: Current Opinion in Microbiology - May 26, 2023 Category: Microbiology Authors: Bei Shi Lee Samsher Singh Kevin Pethe Source Type: research
Comparative safety of bedaquiline and delamanid in patients with multidrug resistant tuberculosis: A nationwide retrospective cohort study
CONCLUSION: This study adds to the emerging evidence refuting the higher mortality rate observed in the bedaquiline trial population. Association between bedaquiline and acute liver injury needs careful interpretation considering for other background hepatotoxic anti-TB drugs. Our finding on delamanid and long QT-related cardiac events suggest careful risk-benefit assessment in patients with pre-existing cardiovascular disease.PMID:37202241 | DOI:10.1016/j.jmii.2023.04.009 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 18, 2023 Category: Microbiology Authors: Ju Hwan Kim Hyesung Lee In-Sun Oh Han Eol Jeong Sungho Bea Seung Hun Jang Hyunjin Son Ju-Young Shin Source Type: research
Comparative safety of bedaquiline and delamanid in patients with multidrug resistant tuberculosis: A nationwide retrospective cohort study
CONCLUSION: This study adds to the emerging evidence refuting the higher mortality rate observed in the bedaquiline trial population. Association between bedaquiline and acute liver injury needs careful interpretation considering for other background hepatotoxic anti-TB drugs. Our finding on delamanid and long QT-related cardiac events suggest careful risk-benefit assessment in patients with pre-existing cardiovascular disease.PMID:37202241 | DOI:10.1016/j.jmii.2023.04.009 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 18, 2023 Category: Microbiology Authors: Ju Hwan Kim Hyesung Lee In-Sun Oh Han Eol Jeong Sungho Bea Seung Hun Jang Hyunjin Son Ju-Young Shin Source Type: research
World Health Organization Guideline on the Management of Tuberculosis in Children: Critical Appraisal, Concerns, and Caution
AbstractIn September 2022, the World Health Organization (WHO) published a new guideline for the management of tuberculosis (TB) in children and adolescents. It included eight new recommendations. Xpert MTB/RIF Ultra (Xpert Ultra) has been designated as the preferred initial diagnostic test for pulmonary TB and detection of rifampicin resistance. But its place vis- à-vis the previously recommended GeneXpert has not been clarified. Further, the limited diagnostic accuracy of Xpert Ultra in some biological specimens like nasopharyngeal aspirates, and the inability to report the presence or absence of rifampicin resistance i...
Source: Indian Journal of Pediatrics - May 17, 2023 Category: Pediatrics Source Type: research
Molecular Epidemiology of Rifampicin-Resistant Mycobacterium tuberculosis by GeneXpert MTB/RIF Assay in Renal Transplant Recipients: A Single-Center Experience
CONCLUSIONS: We report for the first time the incidence and pattern of rifampicin resistance among kidney transplant recipients with tuberculosis infection. Further investigations are required for exploring the molecular and clinical phenotypes.PMID:37154592 | DOI:10.6002/ect.2022.0408 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 8, 2023 Category: Transplant Surgery Authors: Minaxi H Patel Kamla Kanodia Lovelesh Nigam Rashmi Patel Kamlesh Suthar Himanshu Patel Vivek Kute Divyesh Engineer Sanshriti Chauhan Hari Shankar Meshram Source Type: research
Molecular Epidemiology of Rifampicin-Resistant Mycobacterium tuberculosis by GeneXpert MTB/RIF Assay in Renal Transplant Recipients: A Single-Center Experience
CONCLUSIONS: We report for the first time the incidence and pattern of rifampicin resistance among kidney transplant recipients with tuberculosis infection. Further investigations are required for exploring the molecular and clinical phenotypes.PMID:37154592 | DOI:10.6002/ect.2022.0408 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 8, 2023 Category: Transplant Surgery Authors: Minaxi H Patel Kamla Kanodia Lovelesh Nigam Rashmi Patel Kamlesh Suthar Himanshu Patel Vivek Kute Divyesh Engineer Sanshriti Chauhan Hari Shankar Meshram Source Type: research
Molecular Epidemiology of Rifampicin-Resistant Mycobacterium tuberculosis by GeneXpert MTB/RIF Assay in Renal Transplant Recipients: A Single-Center Experience
CONCLUSIONS: We report for the first time the incidence and pattern of rifampicin resistance among kidney transplant recipients with tuberculosis infection. Further investigations are required for exploring the molecular and clinical phenotypes.PMID:37154592 | DOI:10.6002/ect.2022.0408 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 8, 2023 Category: Transplant Surgery Authors: Minaxi H Patel Kamla Kanodia Lovelesh Nigam Rashmi Patel Kamlesh Suthar Himanshu Patel Vivek Kute Divyesh Engineer Sanshriti Chauhan Hari Shankar Meshram Source Type: research
