QT Interval Prolongation with One or More QT-Prolonging Agents Used as Part of a Multidrug Regimen for Rifampicin-Resistant Tuberculosis Treatment: Findings from Two Pediatric Studies
In conclusion, we found a low risk of QTcF interval prolongation in children with RR-TB who received at least one QT-prolonging drug. Greater increases in maximum QTcF and ΔQTcF were observed when MFX and CFZ were used together. Future studies characterizing exposure-QTcF responses in children will be helpful to ensure safety with higher doses if required for effective treatment of RR-TB.PMID:37358463 | DOI:10.1128/aac.01448-22 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - June 26, 2023 Category: Microbiology Authors: Ali Mohamed Ali Kendra K Radtke Anneke C Hesseling Jana Winckler H Simon Schaaf Heather R Draper Bel én P Solans Louvina van der Laan Jennifer Hughes Barend Fourie James Nielsen Anthony J Garcia-Prats Rada M Savic Source Type: research
QT Interval Prolongation with One or More QT-Prolonging Agents Used as Part of a Multidrug Regimen for Rifampicin-Resistant Tuberculosis Treatment: Findings from Two Pediatric Studies
In conclusion, we found a low risk of QTcF interval prolongation in children with RR-TB who received at least one QT-prolonging drug. Greater increases in maximum QTcF and ΔQTcF were observed when MFX and CFZ were used together. Future studies characterizing exposure-QTcF responses in children will be helpful to ensure safety with higher doses if required for effective treatment of RR-TB.PMID:37358463 | DOI:10.1128/aac.01448-22 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - June 26, 2023 Category: Microbiology Authors: Ali Mohamed Ali Kendra K Radtke Anneke C Hesseling Jana Winckler H Simon Schaaf Heather R Draper Bel én P Solans Louvina van der Laan Jennifer Hughes Barend Fourie James Nielsen Anthony J Garcia-Prats Rada M Savic Source Type: research
Corrigendum to: Exposure ‐safety analysis of QTc interval and transaminase levels following bedaquiline administration in patients with drug‐resistant tuberculosis
(Source: CPT: Pharmacometrics and Systems Pharmacology)
Source: CPT: Pharmacometrics and Systems Pharmacology - June 26, 2023 Category: Drugs & Pharmacology Tags: CORRIGENDUM Source Type: research
Advances of new drugs bedaquiline and delamanid in the treatment of multi-drug resistant tuberculosis in children
Tuberculosis (TB) is a major public health problem, with nearly 10 million new cases and millions of deaths each year. Around 10% of these cases are in children, but only a fraction receive proper diagnosis and treatment. The spread of drug-resistant (DR) strain of TB has made it difficult to control, with only 60% of patients responding to treatment. Multi-drug resistant TB (MDR-TB) is often undiagnosed in children due to lack of awareness or under-diagnosis, and the target for children’s DR-TB treatment has only been met in 15% of goals. New medications such as bedaquiline and delamanid have been approved for treating ...
Source: Frontiers in cellular and infection microbiology - June 13, 2023 Category: Microbiology Source Type: research
[ASAP] Application of Enantioselective Sulfur Ylide Epoxidation to a Short Asymmetric Synthesis of Bedaquiline, a Potent Anti-Tuberculosis Drug
Organic LettersDOI: 10.1021/acs.orglett.3c01286 (Source: Organic Letters)
Source: Organic Letters - June 7, 2023 Category: Chemistry Authors: Maryam Bashir, Muhammad Arshad, Robina Begum, and Varinder K. Aggarwal Source Type: research
Bacterial and mammalian F < sub > 1 < /sub > F < sub > O < /sub > -ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Int Rev Cell Mol Biol. 2023;377:45-63. doi: 10.1016/bs.ircmb.2023.01.006. Epub 2023 Feb 1.ABSTRACTThe inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However, small structural divergences distinguish prokaryotic ATP synthases, embedded in cell membranes, from eukaryotic ones localized in ...
Source: International Review of Cell and Molecular Biology - June 2, 2023 Category: Cytology Authors: Salvatore Nesci Source Type: research
Bacterial and mammalian F < sub > 1 < /sub > F < sub > O < /sub > -ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Int Rev Cell Mol Biol. 2023;377:45-63. doi: 10.1016/bs.ircmb.2023.01.006. Epub 2023 Feb 1.ABSTRACTThe inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However, small structural divergences distinguish prokaryotic ATP synthases, embedded in cell membranes, from eukaryotic ones localized in ...
Source: Mol Biol Cell - June 2, 2023 Category: Molecular Biology Authors: Salvatore Nesci Source Type: research
Bacterial and mammalian F < sub > 1 < /sub > F < sub > O < /sub > -ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Int Rev Cell Mol Biol. 2023;377:45-63. doi: 10.1016/bs.ircmb.2023.01.006. Epub 2023 Feb 1.ABSTRACTThe inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However, small structural divergences distinguish prokaryotic ATP synthases, embedded in cell membranes, from eukaryotic ones localized in ...
Source: International Review of Cell and Molecular Biology - June 2, 2023 Category: Cytology Authors: Salvatore Nesci Source Type: research
Bacterial and mammalian F < sub > 1 < /sub > F < sub > O < /sub > -ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Int Rev Cell Mol Biol. 2023;377:45-63. doi: 10.1016/bs.ircmb.2023.01.006. Epub 2023 Feb 1.ABSTRACTThe inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However, small structural divergences distinguish prokaryotic ATP synthases, embedded in cell membranes, from eukaryotic ones localized in ...
Source: International Review of Cell and Molecular Biology - June 2, 2023 Category: Cytology Authors: Salvatore Nesci Source Type: research
Bacterial and mammalian F < sub > 1 < /sub > F < sub > O < /sub > -ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Int Rev Cell Mol Biol. 2023;377:45-63. doi: 10.1016/bs.ircmb.2023.01.006. Epub 2023 Feb 1.ABSTRACTThe inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However, small structural divergences distinguish prokaryotic ATP synthases, embedded in cell membranes, from eukaryotic ones localized in ...
Source: International Review of Cell and Molecular Biology - June 2, 2023 Category: Cytology Authors: Salvatore Nesci Source Type: research
Bacterial and mammalian F < sub > 1 < /sub > F < sub > O < /sub > -ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Int Rev Cell Mol Biol. 2023;377:45-63. doi: 10.1016/bs.ircmb.2023.01.006. Epub 2023 Feb 1.ABSTRACTThe inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However, small structural divergences distinguish prokaryotic ATP synthases, embedded in cell membranes, from eukaryotic ones localized in ...
Source: International Review of Cell and Molecular Biology - June 2, 2023 Category: Cytology Authors: Salvatore Nesci Source Type: research
Bacterial and mammalian F < sub > 1 < /sub > F < sub > O < /sub > -ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Int Rev Cell Mol Biol. 2023;377:45-63. doi: 10.1016/bs.ircmb.2023.01.006. Epub 2023 Feb 1.ABSTRACTThe inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However, small structural divergences distinguish prokaryotic ATP synthases, embedded in cell membranes, from eukaryotic ones localized in ...
Source: International Review of Cell and Molecular Biology - June 2, 2023 Category: Cytology Authors: Salvatore Nesci Source Type: research
Bacterial and mammalian F < sub > 1 < /sub > F < sub > O < /sub > -ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Int Rev Cell Mol Biol. 2023;377:45-63. doi: 10.1016/bs.ircmb.2023.01.006. Epub 2023 Feb 1.ABSTRACTThe inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However, small structural divergences distinguish prokaryotic ATP synthases, embedded in cell membranes, from eukaryotic ones localized in ...
Source: International Review of Cell and Molecular Biology - June 2, 2023 Category: Cytology Authors: Salvatore Nesci Source Type: research
Bacterial and mammalian F < sub > 1 < /sub > F < sub > O < /sub > -ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis
Int Rev Cell Mol Biol. 2023;377:45-63. doi: 10.1016/bs.ircmb.2023.01.006. Epub 2023 Feb 1.ABSTRACTThe inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme maintains the same function of ATP production between the species and a basic molecular mechanism of enzymatic catalysis during ATP synthesis/hydrolysis. However, small structural divergences distinguish prokaryotic ATP synthases, embedded in cell membranes, from eukaryotic ones localized in ...
Source: International Review of Cell and Molecular Biology - June 2, 2023 Category: Cytology Authors: Salvatore Nesci Source Type: research
