Targeting ATP Synthase by Bedaquiline as a Therapeutic Strategy to Sensitize Ovarian Cancer to Cisplatin
This study systematically assessed the efficacy of bedaquiline in ovarian cancer and its underlying mechanism. Using a panel of ovarian cancer cell lines and normal ovary cells, we demonstrated bedaquiline is selective for anti-ovarian cancer activities. Furthermore, the sensitivity varied among different ovarian cancer cell lines regardless of their sensitivity to cisplatin. Bedaquiline inhibited growth, survival and migration, through decreasing levels of ATP synthase subunit, complex V activity, mitochondrial respiration and ATP. We further found that ovarian cancer displayed increased levels of ATP, oxygen consumption ...
Source: Nutrition and Cancer - March 7, 2023 Category: Cancer & Oncology Authors: Hongyan Zhu Qitian Chen Lingling Zhao Pengchao Hu Source Type: research
Targeting ATP Synthase by Bedaquiline as a Therapeutic Strategy to Sensitize Ovarian Cancer to Cisplatin
This study systematically assessed the efficacy of bedaquiline in ovarian cancer and its underlying mechanism. Using a panel of ovarian cancer cell lines and normal ovary cells, we demonstrated bedaquiline is selective for anti-ovarian cancer activities. Furthermore, the sensitivity varied among different ovarian cancer cell lines regardless of their sensitivity to cisplatin. Bedaquiline inhibited growth, survival and migration, through decreasing levels of ATP synthase subunit, complex V activity, mitochondrial respiration and ATP. We further found that ovarian cancer displayed increased levels of ATP, oxygen consumption ...
Source: Nutrition and Cancer - March 7, 2023 Category: Cancer & Oncology Authors: Hongyan Zhu Qitian Chen Lingling Zhao Pengchao Hu Source Type: research
Targeting ATP Synthase by Bedaquiline as a Therapeutic Strategy to Sensitize Ovarian Cancer to Cisplatin
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - March 7, 2023 Category: Cancer & Oncology Authors: Hongyan Zhu Qitian Chen Lingling Zhao Pengchao Hu Source Type: research
Stable, compounded bedaquiline suspensions to support practical implementation of pediatric dosing in the field
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - March 2, 2023 Category: Respiratory Medicine Authors: Taneja, R. Nahata, M. C. Scarim, J. Pande, P. G. Scarim, A. Hoddinott, G. Fourie, C. L. Jew, R. K. Schaaf, H. S. Garcia-Prats, A. J. Hesseling, A. C. Tags: ORIGINAL ARTICLES Source Type: research
Investigation of bedaquiline resistance and genetic mutations in multi-drug resistant Mycobacterium tuberculosis clinical isolates in Chongqing, China
To investigate the prevalence and molecular characterization of bedaquiline resistance among MDR-TB isolates collected from Chongqing, China. (Source: Annals of Clinical Microbiology and Antimicrobials)
Source: Annals of Clinical Microbiology and Antimicrobials - February 28, 2023 Category: Microbiology Authors: Yan Hu, Jun Fan, Damin Zhu, Wenguo Liu, Feina Li, Tongxin Li and Huiwen Zheng Tags: Research Source Type: research
