Role of Nutraceuticals in Treating Erectile Dysfunction via Inhibition of Phosphodiesterase-5 Enzyme: A Mini Review
Curr Pharm Biotechnol. 2024 Jan 16. doi: 10.2174/0113892010256035231119071714. Online ahead of print.ABSTRACTDrug repurposing is an ongoing and clever strategy that is being developed to eradicate tuberculosis amid challenges, of which one of the major challenges is the resistance developed towards antibiotics used in standard directly observed treatment, short-course regimen. Surpassing the challenges in developing anti-tuberculous drugs, some novel host-directed therapies, repurposed drugs, and drugs with novel targets are being studied, and few are being approved too. After almost 4 decades since the approval of rifampi...
Source: Current Pharmaceutical Biotechnology - February 4, 2024 Category: Biotechnology Authors: Rashi Kulshrestha Neelam Singla Obaid Afzal Ahsas Goyal Mahendra Saini Abdulmalik Saleh Alfawaz Altamimi Waleed Hassan Almalki Imran Kazmi Fahad Al-Abbasi Sami I Alzarea Gaurav Gupta Source Type: research
Low body mass index as a predictor of sputum culture conversion and treatment outcomes among patients receiving treatment for multidrug-resistant tuberculosis in Lesotho
CONCLUSIONS: Low BMI was common and associated with the frequency of six-month culture conversion and end-of-treatment outcomes. The association with culture conversion was more pronounced among those not living with HIV. Addressing the myriad factors that drive low BMI in this setting could hasten culture conversion and improve end-of-treatment outcomes. This will require a multipronged approach focused on alleviating food insecurity and enabling prompt diagnosis and treatment of HIV and TB.PMID:38305025 | PMC:PMC10840591 | DOI:10.1080/16549716.2024.2305930 (Source: Global Health Action)
Source: Global Health Action - February 2, 2024 Category: International Medicine & Public Health Authors: Lawrence Oyewusi Chengbo Zeng K J Seung Stephanie Mpinda Mikanda Kunda Carole D Mitnick Makelele Kanu Meseret Tamirat Joalane Makaka Mabatloung Mofolo Refiloe Maime Llang Maama Ninza Senyo Bamidele Oguntoyinbo Lwayi Mayombo Molly F Franke Source Type: research
Drug recommendation for optimization on treatment outcome for MDR/RR-TB based on a multi-center, large scale, retrospective cohort study in China
CONCLUSIONS: The recommendation order for the treatment of MDR/RR-TB is Bdq, Lzd, and Cs. FQs were decreased in use intensity. Injection drugs, whether Amk or Cm, are not recommended.PMID:38251634 | DOI:10.1080/14787210.2024.2303032 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - January 22, 2024 Category: Infectious Diseases Authors: Lin Fan Ming Yang Yu-Tong Han Fei Ren Hua Wang Jin-Bao Ma Guo-Hui Zhu Yan-Jun Xiong Xin-Xin Fan Su-Xia Chen Hao-Yu Wu Wen-Wen Sun Shao-Jun Zhang Hui Ke Xiao-Hong Cheng Biao Xu Yu Chen Chang Chen Source Type: research
Quabodepistat in combination with delamanid and bedaquiline in participants with drug-susceptible pulmonary tuberculosis: protocol for a multicenter, phase 2b/c, open-label, randomized, dose-finding trial to evaluate safety and efficacy
Delamanid and bedaquiline are two of the most recently developed antituberculosis (TB) drugs that have been extensively studied in patients with multidrug-resistant TB. There is currently a need for more poten... (Source: Trials)
Source: Trials - January 19, 2024 Category: General Medicine Authors: Rodney Dawson, Andreas H. Diacon, Simbarashe Takuva, Yongge Liu, Bo Zheng, Vatsala Karwe and Jeffrey Hafkin Tags: Study protocol Source Type: research
Chiral Lithium Amide Improves Stereoselectivity and Yield of Tuberculosis Drug Bedaquiline
Synfacts 2024; 20: 0195- DOI: 10.1055/s-0043-1772954 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Synfacts)
Source: Synfacts - January 16, 2024 Category: Chemistry Tags: Innovative Drug Discovery and Development Source Type: research
The Profile of Multidrug Tuberculosis Regimen and Treatment Outcomes in Pulmonary MDR-TB Patients at the Tertiary Referral Hospital Dr. Soetomo, East Java, Indonesia: A Seven-Year Retrospective Study on Bedaquiline
CONCLUSION: After seven years of study, we revealed an association between adding bedaquiline to the regimen and the treatment success and decreasing lost-to-follow-up cases.PMID:38213049 (Source: Acta medica Indonesiana)
Source: Acta medica Indonesiana - January 12, 2024 Category: Internal Medicine Authors: Muhamad Frendy Setyawan Ni Made Mertaniasih Soedarsono Soedarsono Source Type: research
