Bedquiline Resistance Mutations: Correlations with Drug Exposures and Impact on the Proteome in M. tuberculosis

In conclusion, exposure to different bedaquiline concentrations resulted in the selection of different mutations. The coexpression of MmpL5 and MmpS5 contributed to drug resistance and upregulated pathogenic proteins in M. tuberculosis, suggesting MmpL5-MmpS5 as a new potential target for antituberculosis drug development. These results warrant further surveillance for the evolution of BDQ resistance during clinical usage.PMID:37255473 | DOI:10.1128/aac.01532-22

Source: Antimicrobial Agents and Chemotherapy - May 31, 2023 Category: Microbiology Authors: Jian Xu Dongshuo Li Jinghua Shi Bin Wang Fei Ge Zhenyong Guo Xiaopan Mu Eric Nuermberger Yu Lu Source Type: research