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People with complicated pregnancies may suffer health problems, die early
Preterm births are a well-known hazard for babies—who can require months and sometimes years of extra care—but far less attention is paid to the people who deliver them. Now, a new analysis of more than 2 million pregnancies over 4 decades finds those parents need consideration, too: Even years later, people who experienced some common pregnancy complications had a higher risk of death. “We are starting to understand that pregnancy complications … are windows into longer term complications,” says Cynthia Gyamfi-Bannerman, a maternal fetal medicine specialist at the University of California San Diego who was...
Source: Science of Aging Knowledge Environment - April 15, 2024 Category: Geriatrics Source Type: research

Carnitine palmitoyltransferase II (CPT II) deficiency responsible for refractory cardiac arrhythmias, acute multiorgan failure and early fatal outcome
ConclusionsCPTII deficiency may be suspected in newborns showing cardiac arrhythmias, associated or not with hypertrophic cardiomyopathy, polycystic kidneys, brain malformations, hepatomegaly. Its diagnosis should be even more suspected and investigated in cases of increased plasmatic levels of creatine phosphokinase and acylcarnitines in addition to kidney, heart and liver dysfunctions, as occurred in the present patient. Accurate family history, extended metabolic screening, and multidisciplinary approach are necessary for diagnosis and adequate management of affected subjects. Next generation sequencing (NGS) techniques...
Source: Italian Journal of Pediatrics - April 14, 2024 Category: Pediatrics Source Type: research

Emergency Cardiac Transplant for Refractory Cardiac Arrest Resuscitated with Extracorporeal CardioPulmonary Resuscitation (ECPR) in an 18-Month-Old Baby
Introduction: ABO incompatible (ABOi) heart transplant is currently used routinely for pediatric patients with recipient age (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Vilvanathan, R. Ratnagiri, S. Rao, K. Balakrishnan Source Type: research

RNA binding proteins in cardiovascular development and disease
Curr Top Dev Biol. 2024;156:51-119. doi: 10.1016/bs.ctdb.2024.01.007. Epub 2024 Mar 15.ABSTRACTCongenital heart disease (CHD) is the most common birth defect affecting>1.35 million newborn babies worldwide. CHD can lead to prenatal, neonatal, postnatal lethality or life-long cardiac complications. RNA binding protein (RBP) mutations or variants are emerging as contributors to CHDs. RBPs are wizards of gene regulation and are major contributors to mRNA and protein landscape. However, not much is known about RBPs in the developing heart and their contributions to CHD. In this chapter, we will discuss our current knowledge...
Source: Current Topics in Developmental Biology - March 31, 2024 Category: Biology Authors: Sunil K Verma Muge N Kuyumcu-Martinez Source Type: research