Babesiosis Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Anti-babesial activity of a series of 6,7-dimethoxyquinazoline-2,4-diamines (DMQDAs)
Acta Trop. 2023 Nov 10:107069. doi: 10.1016/j.actatropica.2023.107069. Online ahead of print.ABSTRACTDiminazene aceturate (DA), imidocarb dipropionate (ID), atovaquone (ATO), azithromycin (AZI), clindamycin, and quinine have been used to treat animal and human babesiosis for many years, despite their negative effects and rising indications of resistance. Thus, finding anti-babesial compounds that can either treat the infection or lower the dose of drugs given has been a primary objective. Quinazolines are one of the most important nitrogen heterocycles, with a wide range of pharmacological activities including analgesic, a...
Source: Acta Tropica - November 12, 2023 Category: Infectious Diseases Authors: Shengwei Ji Mohamed Abdo Rizk Eloiza May Galon El-Sayed El-Alfy Yuki Mizukawa Masayoshi Kojima Mayumi Ikegami-Kawai Motohiro Kaya Mingming Liu Isamu Itoh Xuenan Xuan Source Type: research

Evaluation of synergism in essential oils against the cattle tick Rhipicephalus microplus in Burkina Faso
Exp Parasitol. 2023 Nov 8:108643. doi: 10.1016/j.exppara.2023.108643. Online ahead of print.ABSTRACTThe cattle tick Rhipicephalus microplus affects animal production economically by reducing weight gain and milk production and causing diseases, such as babesiosis and anaplasmosis. Using synthetic acaricides to reduce their incidence has caused the emergence of resistant tick populations. The present study aimed to assess the in vitro acaricidal activity of combinations of essential oils (EOs) from Ocimum americanum, Ocimum gratissimum, and Lippia multiflora against R. microplus larvae. In fact, numerous biological properti...
Source: Experimental Parasitology - November 10, 2023 Category: Parasitology Authors: Anass Coulibaly Abel S Biguezoton Delphine M Hema Firmin F Dah Ignace Sawadogo R émy K Bationo Moussa Compaore Martin Kiendrebeogo Roger C H Nebie Source Type: research

Evaluation of the Inhibitory Effect of Moringa oleifera Leaves Methanolic Extract against In Vitro Growth of Several Babesia Species and Theileria equi and the In Vivo Growth of Babesia microti 
J Trop Med. 2023 Oct 31;2023:4285042. doi: 10.1155/2023/4285042. eCollection 2023.ABSTRACTThe current study evaluated the inhibitory effect of Moringa oleifera leaves methanolic extract (MOL) against the in vitro growth of Babesia bovis (B. bovis), B. caballi, B. bigemina, and Theileria equi (T. equi), as well as in vivo growth of B. microti in mice. Active principles of MOL extract were determined using liquid chromatography mass spectrometry (LC-MS). MOL's anti-piroplasm efficacy was assessed both in vitro and in vivo using the SYBR Green I fluorescence assay. Every 96 hours, the hematological parameters, including red b...
Source: Molecular Medicine - November 9, 2023 Category: Molecular Biology Authors: Mohamed Abdo Rizk Shimaa Abd El-Salam El-Sayed Mohamed Z Sayed-Ahmed Yosif Almoshari Saad S Alqahtani Sarfaraz Ahmad Nawazish Alam Basma H Marghani Abdelbaset E Abdelbaset Ikuo Igarashi Source Type: research

Evaluation of the Inhibitory Effect of Moringa oleifera Leaves Methanolic Extract against In Vitro Growth of Several Babesia Species and Theileria equi and the In Vivo Growth of Babesia microti 
J Trop Med. 2023 Oct 31;2023:4285042. doi: 10.1155/2023/4285042. eCollection 2023.ABSTRACTThe current study evaluated the inhibitory effect of Moringa oleifera leaves methanolic extract (MOL) against the in vitro growth of Babesia bovis (B. bovis), B. caballi, B. bigemina, and Theileria equi (T. equi), as well as in vivo growth of B. microti in mice. Active principles of MOL extract were determined using liquid chromatography mass spectrometry (LC-MS). MOL's anti-piroplasm efficacy was assessed both in vitro and in vivo using the SYBR Green I fluorescence assay. Every 96 hours, the hematological parameters, including red b...
Source: Journal of Tropical Medicine - November 9, 2023 Category: Tropical Medicine Authors: Mohamed Abdo Rizk Shimaa Abd El-Salam El-Sayed Mohamed Z Sayed-Ahmed Yosif Almoshari Saad S Alqahtani Sarfaraz Ahmad Nawazish Alam Basma H Marghani Abdelbaset E Abdelbaset Ikuo Igarashi Source Type: research

Experimental infection of non-immunosuppressed and immunosuppressed goats reveals differential pathogenesis of Babesia aktasi n. sp.
In conclusion, this study provides valuable insights into the pathogenicity of the parasite and will serve as a foundation for future research aimed at developing effective prevention and control strategies against babesiosis in small ruminants. Further research is required to investigate the pathogenicity of B. aktasi in various goat breeds, other potential hosts, the vector ticks involved, and its presence in natural reservoirs. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - November 2, 2023 Category: Microbiology Source Type: research

Antiparasitic activity of FLLL-32 against four Babesia species, B. bovis, B. bigemina, B. divergens and B. caballi, and one Theileria species, Theileria equi in vitro, and Babesia microti in mice
Conclusion: The present study demonstrated the antibabesial properties of FLLL-32 and suggested it’s usage in the treatment of babesiosis especially when utilized in combination therapy with other antibabesial drugs. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 2, 2023 Category: Drugs & Pharmacology Source Type: research

Molecular detection of Babesia spp. in dogs in Germany (2007 –2020) and identification of potential risk factors for infection
In Europe, canine babesiosis is most frequently caused by Babesia canis and Babesia vogeli, and occasionally by Babesia gibsoni.. In Germany, B. canis is recognized as endemic. The aims of this study were to asse... (Source: Parasites and Vectors)
Source: Parasites and Vectors - November 2, 2023 Category: Microbiology Authors: Ingo Sch äfer, Christina Sabine Helm, Georg von Samson-Himmelstjerna, Jürgen Krücken, Tanja Kottmann, Annette Holtdirk, Barbara Kohn, Guy Hendrickx, Cedric Marsboom and Elisabeth Müller Tags: Research Source Type: research

Insight into Hyalomma anatolicum biology by comparative genomics analysis
Int J Parasitol. 2023 Oct 17:S0020-7519(23)00192-3. doi: 10.1016/j.ijpara.2023.09.003. Online ahead of print.ABSTRACTHyalomma anatolicum is an obligatory blood-sucking ectoparasite and contributes to the transmission of Crimean-Congo haemorrhagic fever (CCHF) virus, Theileria spp. and Babesia spp. Progress in exploring the adaptive strategy of this ectoparasite and developing tools to fight it has been hindered by the lack of a complete genome. Herein, we assembled the genome using diverse sources of data from multiple sequencing platforms and annotated the 1.96 Gb genome of Hy. anatolicum. Comparative genome analyses and ...
Source: International Journal for Parasitology - October 20, 2023 Category: Parasitology Authors: Jinming Wang Yijun Chai Jifei Yang Kai Chen Guangyuan Liu Jianxun Luo Guiquan Guan Qiaoyun Ren Hong Yin Source Type: research