The role of heat shock protein 90 in the proliferation of Babesia gibsoni in vitro
Exp Parasitol. 2023 Jun 10:108567. doi: 10.1016/j.exppara.2023.108567. Online ahead of print.ABSTRACTThe present study investigated the role of heat shock protein 90 (HSP90) in the proliferation and survival of Babesia gibsoni in vitro. To detect the effect on the entry of B. gibsoni into host erythrocytes, the parasite was incubated with an antibody against B. gibsoni HSP90 (BgHSP90) for 24 hr. The results of this experiment demonstrated that both the incorporation of [3H]hypoxanthine into the nucleic acids of B. gibsoni and the number of parasites were not altered, indicating that an anti-BgHSP90 antibody did not directl...
Source: Experimental Parasitology - June 12, 2023 Category: Parasitology Authors: Hiroka Tsutsumi Moeko Abe Naohiro Uchida Mitsuyoshi Takiguchi Masahiro Yamasaki Source Type: research
The role of heat shock protein 90 in the proliferation of Babesia gibsoni in vitro
Exp Parasitol. 2023 Jun 10:108567. doi: 10.1016/j.exppara.2023.108567. Online ahead of print.ABSTRACTThe present study investigated the role of heat shock protein 90 (HSP90) in the proliferation and survival of Babesia gibsoni in vitro. To detect the effect on the entry of B. gibsoni into host erythrocytes, the parasite was incubated with an antibody against B. gibsoni HSP90 (BgHSP90) for 24 hr. The results of this experiment demonstrated that both the incorporation of [3H]hypoxanthine into the nucleic acids of B. gibsoni and the number of parasites were not altered, indicating that an anti-BgHSP90 antibody did not directl...
Source: Experimental Parasitology - June 12, 2023 Category: Parasitology Authors: Hiroka Tsutsumi Moeko Abe Naohiro Uchida Mitsuyoshi Takiguchi Masahiro Yamasaki Source Type: research
The role of heat shock protein 90 in the proliferation of Babesia gibsoni in vitro
Exp Parasitol. 2023 Jun 10:108567. doi: 10.1016/j.exppara.2023.108567. Online ahead of print.ABSTRACTThe present study investigated the role of heat shock protein 90 (HSP90) in the proliferation and survival of Babesia gibsoni in vitro. To detect the effect on the entry of B. gibsoni into host erythrocytes, the parasite was incubated with an antibody against B. gibsoni HSP90 (BgHSP90) for 24 hr. The results of this experiment demonstrated that both the incorporation of [3H]hypoxanthine into the nucleic acids of B. gibsoni and the number of parasites were not altered, indicating that an anti-BgHSP90 antibody did not directl...
Source: Experimental Parasitology - June 12, 2023 Category: Parasitology Authors: Hiroka Tsutsumi Moeko Abe Naohiro Uchida Mitsuyoshi Takiguchi Masahiro Yamasaki Source Type: research
The role of heat shock protein 90 in the proliferation of Babesia gibsoni in vitro
Exp Parasitol. 2023 Jun 10:108567. doi: 10.1016/j.exppara.2023.108567. Online ahead of print.ABSTRACTThe present study investigated the role of heat shock protein 90 (HSP90) in the proliferation and survival of Babesia gibsoni in vitro. To detect the effect on the entry of B. gibsoni into host erythrocytes, the parasite was incubated with an antibody against B. gibsoni HSP90 (BgHSP90) for 24 hr. The results of this experiment demonstrated that both the incorporation of [3H]hypoxanthine into the nucleic acids of B. gibsoni and the number of parasites were not altered, indicating that an anti-BgHSP90 antibody did not directl...
Source: Experimental Parasitology - June 12, 2023 Category: Parasitology Authors: Hiroka Tsutsumi Moeko Abe Naohiro Uchida Mitsuyoshi Takiguchi Masahiro Yamasaki Source Type: research
Retrospective study of the epidemiological risk and serological diagnosis of human babesiosis in Asturias, Northwestern Spain
Babesiosis is a globally growing tick-borne disease in humans. Severe babesiosis caused by Babesia divergens has been reported in two patients from Asturias (Northwestern Spain), suggesting an undetected risk for... (Source: Parasites and Vectors)
Source: Parasites and Vectors - June 9, 2023 Category: Microbiology Authors: Estrella Montero, Mar ía Folgueras, Mercedes Rodriguez-Pérez, Laura Pérez-ls, Javier Díaz-Arias, Maria Meana, Belén Revuelta, Karita Haapasalo, Julio Collazos, Víctor Asensi and Luis Miguel Gonzalez Tags: Research Source Type: research
Babesia bovis
Trends Parasitol. 2023 Jun 5:S1471-4922(23)00121-6. doi: 10.1016/j.pt.2023.05.003. Online ahead of print.NO ABSTRACTPMID:37280144 | DOI:10.1016/j.pt.2023.05.003 (Source: Trends in Parasitology)
Source: Trends in Parasitology - June 6, 2023 Category: Parasitology Authors: Hassan Hakimi Guilherme G Verocai Source Type: research
Babesia bovis
Trends Parasitol. 2023 Jun 5:S1471-4922(23)00121-6. doi: 10.1016/j.pt.2023.05.003. Online ahead of print.NO ABSTRACTPMID:37280144 | DOI:10.1016/j.pt.2023.05.003 (Source: Trends in Parasitology)
Source: Trends in Parasitology - June 6, 2023 Category: Parasitology Authors: Hassan Hakimi Guilherme G Verocai Source Type: research
Babesia bovis
Trends Parasitol. 2023 Jun 5:S1471-4922(23)00121-6. doi: 10.1016/j.pt.2023.05.003. Online ahead of print.NO ABSTRACTPMID:37280144 | DOI:10.1016/j.pt.2023.05.003 (Source: Trends in Parasitology)
Source: Trends in Parasitology - June 6, 2023 Category: Parasitology Authors: Hassan Hakimi Guilherme G Verocai Source Type: research
Babesia bovis
Trends Parasitol. 2023 Jun 5:S1471-4922(23)00121-6. doi: 10.1016/j.pt.2023.05.003. Online ahead of print.NO ABSTRACTPMID:37280144 | DOI:10.1016/j.pt.2023.05.003 (Source: Trends in Parasitology)
Source: Trends in Parasitology - June 6, 2023 Category: Parasitology Authors: Hassan Hakimi Guilherme G Verocai Source Type: research
Babesia bovis
Trends Parasitol. 2023 Jun 5:S1471-4922(23)00121-6. doi: 10.1016/j.pt.2023.05.003. Online ahead of print.NO ABSTRACTPMID:37280144 | DOI:10.1016/j.pt.2023.05.003 (Source: Trends in Parasitology)
Source: Trends in Parasitology - June 6, 2023 Category: Parasitology Authors: Hassan Hakimi Guilherme G Verocai Source Type: research
Degrade to survive: the intricate world of piroplasmid proteases
Trends Parasitol. 2023 Jun 2:S1471-4922(23)00118-6. doi: 10.1016/j.pt.2023.04.010. Online ahead of print.ABSTRACTPiroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key pr...
Source: Trends in Parasitology - June 4, 2023 Category: Parasitology Authors: Monica Florin-Christensen Daniel Sojka Sabrina Ganzinelli Pavla Šnebergerová Carlos E Suarez Leonhard Schnittger Source Type: research
Degrade to survive: the intricate world of piroplasmid proteases
Trends Parasitol. 2023 Jun 2:S1471-4922(23)00118-6. doi: 10.1016/j.pt.2023.04.010. Online ahead of print.ABSTRACTPiroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key pr...
Source: Trends in Parasitology - June 4, 2023 Category: Parasitology Authors: Monica Florin-Christensen Daniel Sojka Sabrina Ganzinelli Pavla Šnebergerová Carlos E Suarez Leonhard Schnittger Source Type: research
Evaluating the Inhibitory Effect of Resveratrol on the Multiplication of Several Babesia species and Theileria equi on In Vitro Cultures, and Babesia microti in Mice
Histone post-translational modification is one of the most studied factors influencing epigenetic regulation of protozoan parasite gene expression, which is mediated by histone deacetylases (KDACs) and acetyltransferases (KATs). The present study investigated the role of resveratrol (RVT) as an activator of histone deacetylases in the control of various pathogenic Babesia sp. and Theileria equi in vitro, as well as B. microti infected mice in vivo. Its role in mitigating the side effects associated with the widely used antibabesial drugs diminazene aceturate (DA) and azithromycin (AZM) has also been investigated. The in vi...
Source: Frontiers in Pharmacology - May 30, 2023 Category: Drugs & Pharmacology Source Type: research
Molecular detection and characterization of vector-borne agents in common opossums (Didelphis marsupialis) from northeastern Brazil
Acta Trop. 2023 May 24:106955. doi: 10.1016/j.actatropica.2023.106955. Online ahead of print.ABSTRACTOpossums are synanthropic marsupials able to interchange among wild, peri-urban and urban environments, playing an epidemiologically important role as hosts for emerging pathogens and ectoparasites of relevance in public health. The present study aimed to detect and molecularly characterize vector-borne agents in a population of common opossums (Didelphis marsupialis) from the Island of São Luís do Maranhão, northeastern Brazil. Of the 45 animals analyzed, one (2.22%) was positive in the nested PCR assay based on the 18S...
Source: Acta Tropica - May 26, 2023 Category: Infectious Diseases Authors: Maria do Socorro Costa Oliveira Braga Francisco Borges Costa Ana Cl áudia Calchi Vict ória Valente Califre de Mello Anna Claudia Baumel Mongruel Clara Morato Dias Ricardo Bassini-Silva Ellainy Maria Concei ção Silva Jos é Gomes Pereira Larissa Sarmen Source Type: research
Molecular detection and characterization of vector-borne agents in common opossums (Didelphis marsupialis) from northeastern Brazil
Acta Trop. 2023 May 24:106955. doi: 10.1016/j.actatropica.2023.106955. Online ahead of print.ABSTRACTOpossums are synanthropic marsupials able to interchange among wild, peri-urban and urban environments, playing an epidemiologically important role as hosts for emerging pathogens and ectoparasites of relevance in public health. The present study aimed to detect and molecularly characterize vector-borne agents in a population of common opossums (Didelphis marsupialis) from the Island of São Luís do Maranhão, northeastern Brazil. Of the 45 animals analyzed, one (2.22%) was positive in the nested PCR assay based on the 18S...
Source: Acta Tropica - May 26, 2023 Category: Infectious Diseases Authors: Maria do Socorro Costa Oliveira Braga Francisco Borges Costa Ana Cl áudia Calchi Vict ória Valente Califre de Mello Anna Claudia Baumel Mongruel Clara Morato Dias Ricardo Bassini-Silva Ellainy Maria Concei ção Silva Jos é Gomes Pereira Larissa Sarmen Source Type: research
