Valsartan, Losartan and Irbesartan use in the USA, UK, Canada and Denmark after the nitrosamine recalls: a descriptive cohort study
Conclusion
The first recall notice for valsartan resulted in substantial decline in usage due to increased switching to other ARBs. Subsequent notices for losartan and irbesartan were also associated with increased switching around the time of the recall, however, overall usage trends remained unchanged. (Source: BMJ Open)
Source: BMJ Open - April 17, 2023 Category: General Medicine Authors: Eworuke, E., Shinde, M., Hou, L., Paterson, M. J., Jensen, P. B., Maro, J. C., Rai, A., Scarnecchia, D., Pennap, D., Woronow, D., Ghosh, R. E., Welburn, S., Pottegard, A., Platt, R. W., Lee, H., Bradley, M. C. Tags: Open access, Epidemiology Source Type: research
Virtual Screening of Novel 24-Dehydroxysterol Reductase ( < em > DHCR24 < /em > ) Inhibitors and the Biological Evaluation of Irbesartan in Cholesterol-Lowering Effect
Molecules. 2023 Mar 14;28(6):2643. doi: 10.3390/molecules28062643.ABSTRACTHyperlipidemia is a risk factor for the development of fatty liver and cardiovascular diseases such as atherosclerosis and coronary heart disease, and hence, cholesterol-lowering drugs are considered important and effective in preventing cardiovascular diseases. Thus, researchers in the field of new drug development are endeavoring to identify new types of cholesterol-lowering drugs. 3β-hydroxysterol-Δ(24)-reductase (DHCR24) catalyzes the conversion of desmosterol to cholesterol, which is the last step in the cholesterol biosynthesis pathway. We sp...
Source: Atherosclerosis - March 29, 2023 Category: Cardiology Authors: Haozhen Wang Ziyin Lu Yang Li Ting Liu Linlin Zhao Tianqi Gao Xiuli Lu Bing Gao Source Type: research
Molecules, Vol. 28, Pages 2643: Virtual Screening of Novel 24-Dehydroxysterol Reductase (DHCR24) Inhibitors and the Biological Evaluation of Irbesartan in Cholesterol-Lowering Effect
i Lu
Bing Gao
Hyperlipidemia is a risk factor for the development of fatty liver and cardiovascular diseases such as atherosclerosis and coronary heart disease, and hence, cholesterol-lowering drugs are considered important and effective in preventing cardiovascular diseases. Thus, researchers in the field of new drug development are endeavoring to identify new types of cholesterol-lowering drugs. 3&beta;-hydroxysterol-&Delta;(24)-reductase (DHCR24) catalyzes the conversion of desmosterol to cholesterol, which is the last step in the cholesterol biosynthesis pathway. We speculated that blocking the ca...
Source: Molecules - March 14, 2023 Category: Chemistry Authors: Haozhen Wang Ziyin Lu Yang Li Ting Liu Linlin Zhao Tianqi Gao Xiuli Lu Bing Gao Tags: Article Source Type: research
IJERPH, Vol. 20, Pages 4878: Synthesis, Characterization and Application of a MIP-polyHIPE for Selective Extraction of Angiotensin II Receptor Antagonists Residues in Natural Waters
Enrica Calleri
Polymers via high internal phase emulsion (polyHIPEs) were molecularly imprinted with Irbesartan, an antihypertensive drug belonging to the class of angiotensin II receptor antagonists (sartan drugs), chosen for the proof-of-concept extraction of hazardous emerging contaminants from water. Different analyte-functional monomer molar ratios (1:100, 1:30 and 1:15) were investigated, and the MIP polyHIPEs have been characterized, parallel to the not imprinted polymer (NIP), by batch sorption experiments. The material with the highest template-functional monomer ratio was the best for Irbesartan removal, s...
Source: International Journal of Environmental Research and Public Health - March 10, 2023 Category: Environmental Health Authors: Andrea Speltini Giancarla Alberti Riccardo Rovida Chiara Milanese Giulia De Soricellis Francesca Rinaldi Gabriella Massolini Angelo Gallo Enrica Calleri Tags: Article Source Type: research
Selective accumulation of pharmaceutical residues from 6 different soils by plants: a comparative study on onion, radish, and spinach
Environ Sci Pollut Res Int. 2023 Mar 4. doi: 10.1007/s11356-023-26102-5. Online ahead of print.ABSTRACTThe accumulation of six pharmaceuticals of different therapeutic uses has been thoroughly investigated and compared between onion, spinach, and radish plants grown in six soil types. While neutral molecules (e.g., carbamazepine (CAR) and some of its metabolites) were efficiently accumulated and easily translocated to the plant leaves (onion > radish > spinach), the same for ionic (both anionic and cationic) molecules seems to be minor to moderate. The maximum accumulation of CAR crosses 38,000 (onion), 42,000 (radis...
Source: Environmental Science and Pollution Research International - March 4, 2023 Category: Environmental Health Authors: Sunil Paul M Menacherry Radka Kode šová Helena Švecová Ale š Klement Miroslav F ér Anton ín Nikodem Roman Grabic Source Type: research
Selective accumulation of pharmaceutical residues from 6 different soils by plants: a comparative study on onion, radish, and spinach
Environ Sci Pollut Res Int. 2023 Mar 4. doi: 10.1007/s11356-023-26102-5. Online ahead of print.ABSTRACTThe accumulation of six pharmaceuticals of different therapeutic uses has been thoroughly investigated and compared between onion, spinach, and radish plants grown in six soil types. While neutral molecules (e.g., carbamazepine (CAR) and some of its metabolites) were efficiently accumulated and easily translocated to the plant leaves (onion > radish > spinach), the same for ionic (both anionic and cationic) molecules seems to be minor to moderate. The maximum accumulation of CAR crosses 38,000 (onion), 42,000 (radis...
Source: Environmental Science and Pollution Research International - March 4, 2023 Category: Environmental Health Authors: Sunil Paul M Menacherry Radka Kode šová Helena Švecová Ale š Klement Miroslav F ér Anton ín Nikodem Roman Grabic Source Type: research
Canagliflozin ameliorates epithelial-mesenchymal transition in high-salt diet-induced hypertensive renal injury through restoration of sirtuin 3 expression and the reduction of oxidative stress
In this study, we investigated the potential roles of canagliflozin (Cana) on renal EMT and oxidative stress through its effects on sirtuin 3 (SIRT3) expression. High-salt diet (HSD)-induced Dahl salt-sensitive rats hypertensive renal injury led to decreased SIRT3 expression and an increase in EMT and oxidative stress. In contrast, Cana administration rescued SIRT3 expression, decreased both EMT and levels of oxidative stress, and ameliorated renal injury. Furthermore, we compared the antihypertensive and renoprotective properties of Cana when combined with irbesartan (Irb), a renin-angiotensin system (RAS) blocker. We con...
Source: Biochemical and Biophysical Research communications - March 1, 2023 Category: Biochemistry Authors: Zhongli Wang Jianlong Zhai Tingting Zhang Lili He Sai Ma Qingjuan Zuo Guorui Zhang Yan Wang Yifang Guo Source Type: research
Canagliflozin ameliorates epithelial-mesenchymal transition in high-salt diet-induced hypertensive renal injury through restoration of sirtuin 3 expression and the reduction of oxidative stress
In this study, we investigated the potential roles of canagliflozin (Cana) on renal EMT and oxidative stress through its effects on sirtuin 3 (SIRT3) expression. High-salt diet (HSD)-induced Dahl salt-sensitive rats hypertensive renal injury led to decreased SIRT3 expression and an increase in EMT and oxidative stress. In contrast, Cana administration rescued SIRT3 expression, decreased both EMT and levels of oxidative stress, and ameliorated renal injury. Furthermore, we compared the antihypertensive and renoprotective properties of Cana when combined with irbesartan (Irb), a renin-angiotensin system (RAS) blocker. We con...
Source: Biochemical and Biophysical Research communications - March 1, 2023 Category: Biochemistry Authors: Zhongli Wang Jianlong Zhai Tingting Zhang Lili He Sai Ma Qingjuan Zuo Guorui Zhang Yan Wang Yifang Guo Source Type: research
Influence of AGTR1 and ABCB1 Gene Polymorphism on the Curative Effect of Irbesartan
In this study, we investigated the new combinational influences of AGTR1 and ABCB1 gene polymorphism on the therapeutic effect of irbesartan among Chinese hypertensive patients. A total of 353 samples including 168 normal people and 185 hypertensive patients were adopted, and genotypes comprise ABCB1 (CC, CT, and TT) and AGTR1 (AA and AC) in this study. The results of multiple linear regression models showed that no statistically significant differences were observed in blood pressure change following irbesartan administration in each genotype from either ABCB1 (CC, CT, and TT) or AGTR1 (AA and AC). However, spline smoothi...
Source: International Journal of Hypertension - November 21, 2022 Category: Cardiology Authors: Qiao Wang Lingsen You Zeyu Li Leiyi Zhang Xueqi Li Xuesong Yang Source Type: research
Sustained AT < sub > 1 < /sub > R stimulation induces upregulation of growth factors in human cardiac fibroblasts via G < sub > αq < /sub > /TGF- β/ERK signaling that influences myocyte hypertrophy
Eur J Pharmacol. 2022 Nov 10:175384. doi: 10.1016/j.ejphar.2022.175384. Online ahead of print.ABSTRACTStimulation of angiotensin II receptor (ATR) with angiotensin II (Ang II) accelerates cardiac fibroblast activation, resulting in upregulation of cytokines and growth factors. Growth factors were strongly upregulated in animal models of myocardial fibrosis and hypertrophy as well as patients with heart failure. Nevertheless, the signal transduction of ATR for upregulation of growth factors in human cardiac fibroblasts contributing to myocyte hypertrophy have not fully understood. Long-term Ang II treatment of human cardiac...
Source: European Journal of Pharmacology - November 13, 2022 Category: Drugs & Pharmacology Authors: Ratchanee Duangrat Warisara Parichatikanond Noppawan Phumala Morales Darawan Pinthong Supachoke Mangmool Source Type: research
Sustained AT < sub > 1 < /sub > R stimulation induces upregulation of growth factors in human cardiac fibroblasts via G < sub > αq < /sub > /TGF- β/ERK signaling that influences myocyte hypertrophy
Eur J Pharmacol. 2022 Nov 10:175384. doi: 10.1016/j.ejphar.2022.175384. Online ahead of print.ABSTRACTStimulation of angiotensin II receptor (ATR) with angiotensin II (Ang II) accelerates cardiac fibroblast activation, resulting in upregulation of cytokines and growth factors. Growth factors were strongly upregulated in animal models of myocardial fibrosis and hypertrophy as well as patients with heart failure. Nevertheless, the signal transduction of ATR for upregulation of growth factors in human cardiac fibroblasts contributing to myocyte hypertrophy have not fully understood. Long-term Ang II treatment of human cardiac...
Source: European Journal of Pharmacology - November 13, 2022 Category: Drugs & Pharmacology Authors: Ratchanee Duangrat Warisara Parichatikanond Noppawan Phumala Morales Darawan Pinthong Supachoke Mangmool Source Type: research
Determination of antihypertensive drugs irbesartan and doxazosin mesylate in healthcare products and urine samples using surface-enhanced Raman scattering
Anal Bioanal Chem. 2022 Sep 14. doi: 10.1007/s00216-022-04315-w. Online ahead of print.ABSTRACTIn this paper, a surface-enhanced Raman scattering (SERS) strategy was constructed for the determination of antihypertensive drugs irbesartan (IRB) and doxazosin mesylate (DOX). β-Cyclodextrin-capped silver nanoparticles (CD-AgNPs) are employed as SERS-active substrate. The introduction of β-CD with hydrophobic cavity can capture drug molecules to form host-guest complex, making the drug molecules closer to the electromagnetic enhancement field of the AgNPs, thereby enhancing the SERS signal of drug molecules with low Raman cro...
Source: Analytical and Bioanalytical Chemistry - September 13, 2022 Category: Chemistry Authors: Yanru Ding Nan Zhang Junqi Zhao Haiyang Lv Xu Wang Bing Zhao Yuan Tian Source Type: research
Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile-Induced Thoracic Aortopathy in Mice
CONCLUSIONS: Inhibition of either angiotensin II action or production of the renin-angiotensin system does not attenuate β-aminopropionitrile-induced thoracic aortopathies in mice.PMID:36004642 | DOI:10.1161/ATVBAHA.122.317712 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 25, 2022 Category: Cardiology Authors: Hisashi Sawada Satoko Ohno-Urabe Dien Ye Michael K Franklin Jessica J Moorleghen Deborah A Howatt Adam E Mullick Alan Daugherty Hong S Lu Source Type: research
