Moringa isothiocyanate-1 mitigates the damage of oxidative stress and apoptosis in diabetic nephropathy mice
CONCLUSIONS: MIC-1 ameliorated the kidney injury in DN mice, and its mechanism may be associated with the suppression of renal cell apoptosis, oxidative stress, and inflammatory responses.PMID:38623789 | DOI:10.14670/HH-18-741 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 16, 2024 Category: Cytology Authors: Zhou Hua Jiuhong Deng Guiying Wang Source Type: research
Drug-drug interaction between danshensu and irbesartan and its potential mechanism
Xenobiotica. 2024 Apr 9:1-9. doi: 10.1080/00498254.2024.2338183. Online ahead of print.ABSTRACT1. To uncover the effect of danshensu on irbesartan pharmacokinetics and its underlying mechanisms.2. To investigate the effect of danshensu on the pharmacokinetics of irbesartan, Sprague-Dawley rats (n = 6) were orally administered 30 mg/kg irbesartan alone (control group) or pretreated with 160 mg/kg danshensu (experimental group). The effect of danshensu on the metabolic stability of irbesartan in RLMs was examined by LC-MS/MS method. The effect of danshensu on CYP2C9 activity was also determined.3. Danshensu markedly increase...
Source: Xenobiotica - April 9, 2024 Category: Research Authors: Yuexia Li Liheng Liu Source Type: research
Drug-drug interaction between danshensu and irbesartan and its potential mechanism
Xenobiotica. 2024 Apr 9:1-9. doi: 10.1080/00498254.2024.2338183. Online ahead of print.ABSTRACT1. To uncover the effect of danshensu on irbesartan pharmacokinetics and its underlying mechanisms.2. To investigate the effect of danshensu on the pharmacokinetics of irbesartan, Sprague-Dawley rats (n = 6) were orally administered 30 mg/kg irbesartan alone (control group) or pretreated with 160 mg/kg danshensu (experimental group). The effect of danshensu on the metabolic stability of irbesartan in RLMs was examined by LC-MS/MS method. The effect of danshensu on CYP2C9 activity was also determined.3. Danshensu markedly increase...
Source: Xenobiotica - April 9, 2024 Category: Research Authors: Yuexia Li Liheng Liu Source Type: research
Drug-drug interaction between danshensu and irbesartan and its potential mechanism
Xenobiotica. 2024 Apr 9:1-9. doi: 10.1080/00498254.2024.2338183. Online ahead of print.ABSTRACT1. To uncover the effect of danshensu on irbesartan pharmacokinetics and its underlying mechanisms.2. To investigate the effect of danshensu on the pharmacokinetics of irbesartan, Sprague-Dawley rats (n = 6) were orally administered 30 mg/kg irbesartan alone (control group) or pretreated with 160 mg/kg danshensu (experimental group). The effect of danshensu on the metabolic stability of irbesartan in RLMs was examined by LC-MS/MS method. The effect of danshensu on CYP2C9 activity was also determined.3. Danshensu markedly increase...
Source: Xenobiotica - April 9, 2024 Category: Research Authors: Yuexia Li Liheng Liu Source Type: research
Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other...
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: S üleyman Cihan Kara U ğur Canpolat Source Type: research
Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other...
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: S üleyman Cihan Kara U ğur Canpolat Source Type: research
Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other...
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: S üleyman Cihan Kara U ğur Canpolat Source Type: research
Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other...
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: S üleyman Cihan Kara U ğur Canpolat Source Type: research
Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other...
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: S üleyman Cihan Kara U ğur Canpolat Source Type: research
Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other...
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: S üleyman Cihan Kara U ğur Canpolat Source Type: research
Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other...
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: S üleyman Cihan Kara U ğur Canpolat Source Type: research
Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other...
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: S üleyman Cihan Kara U ğur Canpolat Source Type: research
Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other...
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: S üleyman Cihan Kara U ğur Canpolat Source Type: research
Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other...
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: S üleyman Cihan Kara U ğur Canpolat Source Type: research
