Prioritization based on risk assessment to study the bioconcentration and biotransformation of pharmaceuticals in glass eels (Anguilla anguilla) from the Adour estuary (Basque Country, France)
Environ Pollut. 2022 Aug 22:120016. doi: 10.1016/j.envpol.2022.120016. Online ahead of print.ABSTRACTThe presence of contaminants of emerging concern in the aquatic environment directly impacts water-living organisms and can alter their living functions. These compounds are often metabolized and excreted, but they can also be accumulated and spread through the food chain. The metabolized contaminants can also lead to the formation of new compounds with unknown toxicity and bioaccumulation potential. In this work, we have studied the occurrence, bioconcentration, and biotransformation of CECs in glass eels (Anguilla anguill...
Source: Environmental Pollution - August 25, 2022 Category: Environmental Health Authors: Iker Alvarez-Mora Val érie Bolliet Naroa Lopez-Herguedas Lyen Castro Eneritz Anakabe Mathilde Monperrus Nestor Etxebarria Source Type: research
Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile-Induced Thoracic Aortopathy in Mice
CONCLUSIONS: Inhibition of either angiotensin II action or production of the renin-angiotensin system does not attenuate β-aminopropionitrile-induced thoracic aortopathies in mice.PMID:36004642 | DOI:10.1161/ATVBAHA.122.317712 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 25, 2022 Category: Cardiology Authors: Hisashi Sawada Satoko Ohno-Urabe Dien Ye Michael K Franklin Jessica J Moorleghen Deborah A Howatt Adam E Mullick Alan Daugherty Hong S Lu Source Type: research
Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile-Induced Thoracic Aortopathy in Mice
CONCLUSIONS: Inhibition of either angiotensin II action or production of the renin-angiotensin system does not attenuate β-aminopropionitrile-induced thoracic aortopathies in mice.PMID:36004642 | DOI:10.1161/ATVBAHA.122.317712 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 25, 2022 Category: Cardiology Authors: Hisashi Sawada Satoko Ohno-Urabe Dien Ye Michael K Franklin Jessica J Moorleghen Deborah A Howatt Adam E Mullick Alan Daugherty Hong S Lu Source Type: research
Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile-Induced Thoracic Aortopathy in Mice
CONCLUSIONS: Inhibition of either angiotensin II action or production of the renin-angiotensin system does not attenuate β-aminopropionitrile-induced thoracic aortopathies in mice.PMID:36004642 | DOI:10.1161/ATVBAHA.122.317712 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 25, 2022 Category: Cardiology Authors: Hisashi Sawada Satoko Ohno-Urabe Dien Ye Michael K Franklin Jessica J Moorleghen Deborah A Howatt Adam E Mullick Alan Daugherty Hong S Lu Source Type: research
Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile-Induced Thoracic Aortopathy in Mice
CONCLUSIONS: Inhibition of either angiotensin II action or production of the renin-angiotensin system does not attenuate β-aminopropionitrile-induced thoracic aortopathies in mice.PMID:36004642 | DOI:10.1161/ATVBAHA.122.317712 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 25, 2022 Category: Cardiology Authors: Hisashi Sawada Satoko Ohno-Urabe Dien Ye Michael K Franklin Jessica J Moorleghen Deborah A Howatt Adam E Mullick Alan Daugherty Hong S Lu Source Type: research
Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway
CONCLUSION: DN golden hamster kidney NLRP3-Caspase-1-GSDMD signalling was enhanced. BBR can reduce oxidative stress damage by regulating antioxidative Nrf2 and then regulating NLRP3-Caspase-1-GSDMD signalling to inhibit pyroptosis, antagonizing DN inflammation-induced damage.PMID:35971382 | PMC:PMC9375700 | DOI:10.1155/2021/5545193 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - August 16, 2022 Category: Complementary Medicine Authors: Baozhu Ding Songyan Geng Xiaojie Hou Xuelian Ma Huazhou Xu Fan Yang Kun Liu Wenjie Liang Guoping Ma Source Type: research
Molecules, Vol. 27, Pages 5134: Virtual Screening for FDA-Approved Drugs That Selectively Inhibit Arginase Type 1 and 2
In this study, a dataset containing 2115-FDA-approved drug molecules is virtually screened for potential arginase binding using molecular docking against several ARG1 and ARG2 structures. The potential arginase ligands are classified into three categories: (1) Non-selective, (2) ARG1 selective, and (3) ARG2 selective. The evaluated potential arginase ligands are then compared with their clinical use. Remarkably, half of the top 30 potential drugs are used clinically to lower blood pressure and treat cancer, infection, kidney disease, and Parkinson’s disease thus partially validating our virtual screen. Most n...
Source: Molecules - August 12, 2022 Category: Chemistry Authors: Trishna Saha Detroja Abraham O. Samson Tags: Article Source Type: research
[ASAP] Development of a New Synthetic Route of the Key Intermediate of Irbesartan
Organic Process Research& DevelopmentDOI: 10.1021/acs.oprd.2c00113 (Source: Organic Process Research and Development)
Source: Organic Process Research and Development - August 4, 2022 Category: Chemistry Authors: Zhaohang Chen, Yuanxia Guo, Huilong Niu, Jinxin Wang, Jianming Li, Chao Li, and Renzhong Qiao Source Type: research
Methylglyoxal enhances the proliferation of vascular smooth muscle cells via Akt phosphorylation
This study inspected the proliferative capacity of MGO in vascular smooth muscle cells (VSMCs), which have a crucial role in atherosclerosis and restenosis. The roles of ERK1/2 MAPK and Akt phosphorylations in proliferation were determined. Telmisartan, irbesartan, and NF-κB inhibitor JSH-23's roles in protecting the cells from MGO-induced proliferation were also investigated. Primary VSMCs were isolated from the rat aorta. The proliferation was spectrophotometrically measured by using a tetrazolium salt (Wst-1). The cells were cultured in standard media (SM, glucose conc. 5.5 mM) or high glucose media (HGM, glucose conc....
Source: Atherosclerosis - July 12, 2022 Category: Cardiology Authors: Mustafa K ırça Source Type: research
Methylglyoxal enhances the proliferation of vascular smooth muscle cells via Akt phosphorylation
This study inspected the proliferative capacity of MGO in vascular smooth muscle cells (VSMCs), which have a crucial role in atherosclerosis and restenosis. The roles of ERK1/2 MAPK and Akt phosphorylations in proliferation were determined. Telmisartan, irbesartan, and NF-κB inhibitor JSH-23's roles in protecting the cells from MGO-induced proliferation were also investigated. Primary VSMCs were isolated from the rat aorta. The proliferation was spectrophotometrically measured by using a tetrazolium salt (Wst-1). The cells were cultured in standard media (SM, glucose conc. 5.5 mM) or high glucose media (HGM, glucose conc....
Source: Atherosclerosis - July 12, 2022 Category: Cardiology Authors: Mustafa K ırça Source Type: research
Mesocosm constructed wetlands to remove micropollutants from wastewater treatment plant effluent: Effect of matrices and pre-treatments
In this study, the removal of MPs was evaluated in seven vertical flow mesocosm CWs with different configurations, including different support matrices (sand and a combination of bark-biochar), light pre-treatments (UVC and sunlight) or bioaugmentation in support matrices (activated sludge). The CWs with bark-biochar as support matrix significantly enhanced the removal of irbesartan and carbamazepine (>40%), compared to the CW filled with the conventional support matrix sand. UVC irradiation as pre-treatment was more efficient in removing MPs than sunlight irradiation. After UVC pre-treatment, less MPs accumulated in th...
Source: Chemosphere - June 17, 2022 Category: Chemistry Authors: Yu Lei Huub Rijnaarts Alette Langenhoff Source Type: research
Mesocosm constructed wetlands to remove micropollutants from wastewater treatment plant effluent: Effect of matrices and pre-treatments
In this study, the removal of MPs was evaluated in seven vertical flow mesocosm CWs with different configurations, including different support matrices (sand and a combination of bark-biochar), light pre-treatments (UVC and sunlight) or bioaugmentation in support matrices (activated sludge). The CWs with bark-biochar as support matrix significantly enhanced the removal of irbesartan and carbamazepine (>40%), compared to the CW filled with the conventional support matrix sand. UVC irradiation as pre-treatment was more efficient in removing MPs than sunlight irradiation. After UVC pre-treatment, less MPs accumulated in th...
Source: Chemosphere - June 17, 2022 Category: Chemistry Authors: Yu Lei Huub Rijnaarts Alette Langenhoff Source Type: research
Different Approaches in Manipulating Ratio Spectra for Analyzing Amlodipine besylate and Irbesartan Combination
CONCLUSION: Eventually, the introduced methods were successfully applied for the assay of the cited drugs in their marketed formulation. They could be efficiently used for routine analysis of the mentioned drugs in quality control laboratories.HIGHLIGHTS: The proposed approaches do not require expensive solvents or complex instruments. They could be used in routine laboratory tests where the time and cost are crucial.PMID:35689609 | DOI:10.1093/jaoacint/qsac073 (Source: Atherosclerosis)
Source: Atherosclerosis - June 11, 2022 Category: Cardiology Authors: Dina A El Mously Nadia M Mostafa Nagiba Y Hassan Ghada M El-Sayed Source Type: research
Different Approaches in Manipulating Ratio Spectra for Analyzing Amlodipine besylate and Irbesartan Combination
CONCLUSION: Eventually, the introduced methods were successfully applied for the assay of the cited drugs in their marketed formulation. They could be efficiently used for routine analysis of the mentioned drugs in quality control laboratories.HIGHLIGHTS: The proposed approaches do not require expensive solvents or complex instruments. They could be used in routine laboratory tests where the time and cost are crucial.PMID:35689609 | DOI:10.1093/jaoacint/qsac073 (Source: Atherosclerosis)
Source: Atherosclerosis - June 11, 2022 Category: Cardiology Authors: Dina A El Mously Nadia M Mostafa Nagiba Y Hassan Ghada M El-Sayed Source Type: research
