Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway

CONCLUSION: DN golden hamster kidney NLRP3-Caspase-1-GSDMD signalling was enhanced. BBR can reduce oxidative stress damage by regulating antioxidative Nrf2 and then regulating NLRP3-Caspase-1-GSDMD signalling to inhibit pyroptosis, antagonizing DN inflammation-induced damage.PMID:35971382 | PMC:PMC9375700 | DOI:10.1155/2021/5545193

Source: Evidence-based Complementary and Alternative Medicine - August 16, 2022 Category: Complementary Medicine Authors: Baozhu Ding Songyan Geng Xiaojie Hou Xuelian Ma Huazhou Xu Fan Yang Kun Liu Wenjie Liang Guoping Ma Source Type: research