Growth "self-inhibition" of irbesartan desmotrope: surface intra-annular tautomer inter-conversion is the culprit
Chem Commun (Camb). 2024 Feb 27. doi: 10.1039/d3cc06170a. Online ahead of print.ABSTRACTThe newly discovered growth self-inhibition phenomenon of tautomeric crystals is now generalized to the demostrope (form B) of irbesartan that displays intra-annular tautomerism in neutral aqueous solutions. The dynamic intra-annular tautomer inter-conversion on the surface is the key factor. Our findings provide implications for producing and engineering tautomeric materials.PMID:38410911 | DOI:10.1039/d3cc06170a (Source: Chemical Communications)
Source: Chemical Communications - February 27, 2024 Category: Chemistry Authors: Xiang Kang Mingtao Zhang Weiwei Tang Junbo Gong Source Type: research
Growth "self-inhibition" of irbesartan desmotrope: surface intra-annular tautomer inter-conversion is the culprit
Chem Commun (Camb). 2024 Feb 27. doi: 10.1039/d3cc06170a. Online ahead of print.ABSTRACTThe newly discovered growth self-inhibition phenomenon of tautomeric crystals is now generalized to the demostrope (form B) of irbesartan that displays intra-annular tautomerism in neutral aqueous solutions. The dynamic intra-annular tautomer inter-conversion on the surface is the key factor. Our findings provide implications for producing and engineering tautomeric materials.PMID:38410911 | DOI:10.1039/d3cc06170a (Source: Chemical Communications)
Source: Chemical Communications - February 27, 2024 Category: Chemistry Authors: Xiang Kang Mingtao Zhang Weiwei Tang Junbo Gong Source Type: research
Nitrosamines, ICH Q3A-Q3E, Global Substance Registration System (GSRS), N-nitroso dimethyl amine (NDMA), Drug substance life cycle
Curr Top Med Chem. 2024 Feb 6. doi: 10.2174/0115680266278636240125113509. Online ahead of print.ABSTRACTSince their discovery in valsartan-containing drugs, nitrosamine impurities have emerged as a significant safety problem in pharmaceutical products, prompting extensive recalls and suspensions. Valsartan, candesartan, irbesartan, olmesartan, and other sartans have been discovered to have additional nitrosamine impurities, such as N-nitroso-N-methyl-4-aminobutyric acid (NMBA), N-nitroso-Di-isopropyl amine (NDIPA), N-nitroso-Ethyl-Isopropyl amine (NEIPA), and N-nitroso-Diethyl amine (NDEA). Concerns about drug safety have ...
Source: Current Topics in Medicinal Chemistry - February 7, 2024 Category: Chemistry Authors: Darshan Bhirud Gyan Agrawal Harshil Shah Artiben Patel Mahesh B Palkar Sankha Bhattacharya Bhupendra G Prajapati Source Type: research
Mimicking pneumonia with septic shock: A case report and literature review
Exp Ther Med. 2023 Dec 20;27(2):73. doi: 10.3892/etm.2023.12361. eCollection 2024 Feb.ABSTRACTHydrochlorothiazide (HCTZ) is a commonly used diuretic antihypertensive drug that can cause electrolyte disorders, hyperglycemia and hyperuricemia as well as rare life-threatening adverse drug reactions. These include non-cardiogenic pulmonary edema, interstitial pneumonia, angioedema and aplastic anemia. The present report describes a case of a 59-year-old man who developed a hypersensitivity reaction to HCTZ. Specifically, the patient presented with symptoms of cough, chest tightness and shortness of breath, with pneumonic conso...
Source: Experimental and Therapeutic Medicine - January 24, 2024 Category: General Medicine Authors: Yufang Guo Qiuqi Lin Zexu Wang Ping Zhan Liangquan Wu Xia Pan Xiuwei Zhang Li Wang Bing Wan Source Type: research
Irbesartan eases lipopolysaccharide-induced lung injury < em > In Vitro < /em > and < em > In Vivo < /em >
Chin J Physiol. 2023 Nov-Dec;66(6):516-525. doi: 10.4103/cjop.CJOP-D-23-00131.ABSTRACTAcute lung injury (ALI) is classified as a devastating pulmonary disorder contributing to significant incidence and fatality rate. Irbesartan (IRB) is an angiotensin II receptor blocker that has been proposed to protect against oleic acid-induced ALI. To this end, the current study is concentrated on ascertaining the role of IRB in ALI and figuring out the probable action mechanism. First, cell counting kit-8 (CCK-8) appraised the viability of human pulmonary microvascular endothelial cells (HPMVECs) exposed to ascending concentrations of...
Source: The Chinese Journal of Physiology - December 27, 2023 Category: Physiology Authors: Zhongyuan Zhang Wei Wang Source Type: research
