Growth "self-inhibition" of irbesartan desmotrope: surface intra-annular tautomer inter-conversion is the culprit

Chem Commun (Camb). 2024 Feb 27. doi: 10.1039/d3cc06170a. Online ahead of print.ABSTRACTThe newly discovered growth self-inhibition phenomenon of tautomeric crystals is now generalized to the demostrope (form B) of irbesartan that displays intra-annular tautomerism in neutral aqueous solutions. The dynamic intra-annular tautomer inter-conversion on the surface is the key factor. Our findings provide implications for producing and engineering tautomeric materials.PMID:38410911 | DOI:10.1039/d3cc06170a

Source: Chemical Communications - February 27, 2024 Category: Chemistry Authors: Xiang Kang Mingtao Zhang Weiwei Tang Junbo Gong Source Type: research