Screening and prioritization of organic chemicals in a large river basin by suspect and non-target analysis
Environ Pollut. 2023 Jun 21:122098. doi: 10.1016/j.envpol.2023.122098. Online ahead of print.ABSTRACTMany organic chemicals are present in aquatic environments, but how to screen and prioritize these chemicals has always been a difficult task. Here we investigated organic chemicals in the West River Basin by using a developed non-target identification workflow. A total of 957 chemicals were tentatively identified, with 96 assigned as high confidence levels by matching with reference standards, MassBank spectral library, and using CompTox Chemistry Dashboard database as the compound library for MetFrag. More pesticides and ...
Source: Environmental Pollution - June 23, 2023 Category: Environmental Health Authors: Jia-Hui Zhao Li-Xin Hu Sheng Xiao Jian-Liang Zhao You-Sheng Liu Bin Yang Qian-Qian Zhang Guang-Guo Ying Source Type: research
PPAR α activator irbesartan suppresses the proliferation of endometrial carcinoma cells via SREBP1 and ARID1A
Oncol Res. 2023 May 24;31(3):239-253. doi: 10.32604/or.2023.026067. eCollection 2023.ABSTRACTEndometrial carcinoma (EMC) is associated with obesity; however, the underlying mechanisms have not yet been elucidated. Peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear receptor that is involved in lipid, glucose, and energy metabolism. PPARα reportedly functions as a tumor suppressor through its effects on lipid metabolism; however, the involvement of PPARα in the development of EMC remains unclear. The present study demonstrated that the immunohistochemical expression of nuclear PPARα was lower in EMC th...
Source: Oncology Research - June 12, 2023 Category: Cancer & Oncology Authors: Y U Lu Tsutomu Miyamoto Hodaka Takeuchi Fumi Tsunoda Naoki Tanaka Tanri Shiozawa Source Type: research
