Cardiomyocyte Adaptation to Exercise: K+ Channels,
Contractility and Ischemic Injury
Int J Sports Med DOI: 10.1055/a-2296-7604Cardiovascular disease is a leading cause of morbidity and mortality, and
exercise-training (TRN) is known to reduce risk factors and protect the heart
from ischemia and reperfusion injury. Though the cardioprotective effects of
exercise are well-documented, underlying mechanisms are not well understood.
This review highlights recent findings and focuses on cardiac factors with
emphasis on K+ channel control of the action potential duration
(APD), β-adrenergic and adenosine regulation of cardiomyocyte function, and
...
Source: International Journal of Sports Medicine - April 22, 2024 Category: Sports Medicine Authors: Fitts, Robert H. Wang, Xinrui Kwok, Wai-Meng Camara, Amadou K. S. Tags: Review Source Type: research
Editorial to “Association of Left Atrial Appendage Morphology and Function with Stroke and Transient Ischemic Attack in Atrial Fibrillation Patients”
Atrial fibrillation (AF) is the most commonly encountered arrhythmia in clinical practice and is an independent risk factor for strokes. A thromboembolic event risk assessment based on the CHA2DS2-VASc score is recommended by the guidelines. However, strokes also occur even in some populations with low CHA2DS2-VASc scores. Thus, new factors to improve the risk stratification of thromboembolic events are needed. A major embolic source associated with AF is the left atrial appendage (LAA). Previous reports showed that the LAA endocardium has more enhanced expression of a prothrombotic profile and proinflammatory proteins tha...
Source: The American Journal of Cardiology - April 22, 2024 Category: Cardiology Authors: Satoshi Higa Tags: Editorial Source Type: research
Evolving Applications of Echocardiography in the Evaluation of Left Atrial and Right Ventricular Strain
AbstractPurpose of ReviewSpeckle-tracking echocardiography (STE) can assess myocardial motion in non-LV chambers —including assessment of left atrial (LA) and right ventricular (RV) strain. This review seeks to highlight the diagnostic, prognostic, and clinical significance of these parameters in heart failure, atrial fibrillation (AF), diastolic dysfunction, pulmonary hypertension (PH), tricuspid regurgitat ion, and heart transplant recipients.Recent FindingsImpaired LA strain reflects worse LV diastolic function in individuals with and without HF, and this is associated with decreased exercise capacity. Initiating trea...
Source: Current Cardiology Reports - April 22, 2024 Category: Cardiology Source Type: research
Thyroid dysfunction in nonvalvular atrial fibrillation and clinical outcomes
ConclusionLow T3 syndrome are linked to an increased risk of heart failure and all-cause death in individuals with NVAF. And Patients with NVAF and low TT3 levels have a higher risk of thromboembolism. (Source: Endocrine)
Source: Endocrine - April 22, 2024 Category: Endocrinology Source Type: research
Safety and effectiveness of anticoagulation in the management of acute stroke and transient ischemic attack due to intracranial and extracranial non-occlusive thrombus
CONCLUSION: Anticoagulant treatment is safe and effective in symptomatic patients with intracranial or extracranial artery nonocclusive thrombus, regardless of the anticoagulant type, thrombus location and size.PMID:38643651 | DOI:10.1016/j.jocn.2024.04.012 (Source: Atherosclerosis)
Source: Atherosclerosis - April 21, 2024 Category: Cardiology Authors: Aysenur Onalan Erdem Gurkas Cetin Kursad Akpinar Ozlem Aykac Zehra Uysal Kocabas Hasan Dogan Musa Temel Atilla Ozcan Ozdemir Source Type: research
Outcomes of combined left bundle branch area pacing with atrioventricular nodal ablation in patients with atrial fibrillation and pulmonary disease
ConclusionThis small, retrospective cohort study suggests concomitant LBBAP with AV nodal ablation may be safe and efficacious for management of atrial fibrillation in patients with advanced pulmonary disease. (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - April 21, 2024 Category: Cardiology Authors: Christopher Sefton,
Christine Tanaka ‐Esposito,
Thomas Dresing,
Justin Lee,
Roy Chung Tags: ORIGINAL ARTICLE Source Type: research
Impaired fibrinolysis in patients with atrial fibrillation and elevated circulating lipopolysaccharide
This study is the first to demonstrate antifibrinolytic effects of elevated LPS in AF patients largely driven by enhanced PAI-1 release. (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - April 21, 2024 Category: Hematology Source Type: research
Analyses of lncRNA and mRNA profiles in recurrent atrial fibrillation after catheter ablation
ConclusionsThe recurrence of atrial fibrillation after catheter ablation may be associated with immune responses and fibrosis, with the extracellular matrix playing a crucial role. TMEM51-AS1-201 has been identified as a potential key target for AF recurrence after catheter ablation. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 20, 2024 Category: Research Source Type: research
Pulsed field ablation for atrial fibrillation when in proximity to LAA AtriClip: the LAA-Clip does not inhibit the pulse
(Source: Journal of Interventional Cardiac Electrophysiology)
Source: Journal of Interventional Cardiac Electrophysiology - April 20, 2024 Category: Cardiology Source Type: research
Redefining cardiac care: the promising horizon of epicardial pulse field ablation for postoperative atrial fibrillation
(Source: Journal of Interventional Cardiac Electrophysiology)
Source: Journal of Interventional Cardiac Electrophysiology - April 20, 2024 Category: Cardiology Source Type: research
Cowboys Will Always Be Cowboys – But Not Everyone Should Join The Rodeo
The term cowboys will always be cowboys has been used to describe cowboys on western ranches and also to describe the Dallas Cowboys football team mantra. Some have also used it in a somewhat pejorative manner when referring to interventional cardiologists who want to stent every stenosis they see or to cardiac electrophysiologists who want to ablate (Abl) atrial fibrillation (AF) whenever they encounter it. The latter may be in large part the result of the current emphasis on ablation in clinical cardiology electrophysiology training programs as can be seen in Figures 1 and 2. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 20, 2024 Category: Cardiology Authors: James A. Reiffel Tags: Editorial Source Type: research
Partial CArdiac Denervation to prevent PostOperative Atrial Fibrillation after coronary artery bypass grafting (pCAD-POAF): study protocol for a randomized controlled trial
This study is aimed to evaluate the effect of partial cardiac denervation, which is achieved by cutting off the ligament of Marshall and resecting the fat pad along the Waterston groove, on the prevention of POAF after CABG. Patients planned for CABG at our center will be screened for eligibility for this study. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 20, 2024 Category: Cardiology Authors: Ziang Yang, Xieraili Tiemuerniyazi, Shengkang Huang, Yangwu Song, Fei Xu, Wei Feng Source Type: research
Is pre-diabetes a predictor of events in patients with atrial fibrillation?
Diabetes mellitus (DM) increases the probability of presenting atrial fibrillation (AF) and it is a predictor of its ischemic stroke. There is limited information of the association between glycated hemoglobin (HbA1c) levels and ischemic, embolic or bleeding events in patients with pre-DM and AF. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 20, 2024 Category: Cardiology Authors: Ana Ledo Pi ñeiro, Emad Abu-Assi, Inmaculada González Bermúdez, Vanesa Noriega Caro, Andrés Íñiguez-Romo, Sergio Raposeiras-Roubín Source Type: research
Response to “Characteristics of the prothrombotic milieu in mitral stenosis patients managed with direct oral anticoagulants”
We read Dr. Jolobe's valuable comments regarding our study. We believe that any recommendation on the utility of direct oral anticoagulants (DOACs) in mitral stenosis (MS) patients with atrial fibrillation (AF) should only be based on the recently published INVICTUS trial [1] providing reliable evidence on the superiority of vitamin K antagonists (VKAs) compared to DOACs. However, the excellent time-in-therapeutic-range in the VKA group in INVICTUS [1] is in contrast with the current real-world experience in countries with a high prevalence of rheumatic heart disease [2], which opens a debate on the transferability of INVI...
Source: International Journal of Cardiology - April 20, 2024 Category: Cardiology Authors: Parham Sadeghipour, Mohammadhossein Mozafarybazargany, Melody Farrashi, Raffaele De Caterina Source Type: research
