Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response
CONCLUSION: The simultaneous treatment of resistant colorectal cancer cells with 5-FU and ATR inhibitor, VE-822, was demonstrated to be effective in reversing drug resistance and potentiating 5-FU mediated anticancer effects via targeting DNA damage.PMID:38553623 | DOI:10.1007/s11033-024-09431-7 (Source: Mol Biol Cell)
Source: Mol Biol Cell - March 30, 2024 Category: Molecular Biology Authors: Ainaz Mihanfar Faezeh Asghari Maryam Majidinia Source Type: research
Depletion of CNOT4 modulates the DNA damage responses following ionizing radiation (IR)
CONCLUSION: We conclude that depletion of CNOT4 affects various aspects of the cellular response to DNA damage.PMID:38554309 | DOI:10.4103/jcrt.jcrt_1723_22 (Source: Cell Research)
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Samira Eskandarian Roger J Grand Shiva Irani Mohsen Saeedi Reza Mirfakhraie Source Type: research
Harmine alleviated STZ-induced rat diabetic nephropathy: A potential role via regulating AMPK/Nrf2 pathway and deactivating ataxia-telangiectasia mutated (ATM) signaling
Int Immunopharmacol. 2024 Mar 29;132:111954. doi: 10.1016/j.intimp.2024.111954. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) is a serious kidney disorder driven by diabetes and affects people all over the world. One of the mechanisms promoting NF-κB-induced renal inflammation and injury has been theorized to be ATM signaling. On the other hand, AMPK, which can be activated by the naturally occurring alkaloid harmine (HAR), has been proposed to stop that action. As a result, the goal of this study was to evaluate the therapeutic effectiveness of HAR against streptozotocin (STZ)-induced DN in rats through AMPK-me...
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Manar Mohammed El Tabaa Maram Mohammed El Tabaa Eman Rashad Mohammed Salah Elballal Ola Elazazy Source Type: research
Depletion of CNOT4 modulates the DNA damage responses following ionizing radiation (IR)
CONCLUSION: We conclude that depletion of CNOT4 affects various aspects of the cellular response to DNA damage.PMID:38554309 | DOI:10.4103/jcrt.jcrt_1723_22 (Source: Cancer Control)
Source: Cancer Control - March 30, 2024 Category: Cancer & Oncology Authors: Samira Eskandarian Roger J Grand Shiva Irani Mohsen Saeedi Reza Mirfakhraie Source Type: research
Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response
CONCLUSION: The simultaneous treatment of resistant colorectal cancer cells with 5-FU and ATR inhibitor, VE-822, was demonstrated to be effective in reversing drug resistance and potentiating 5-FU mediated anticancer effects via targeting DNA damage.PMID:38553623 | DOI:10.1007/s11033-024-09431-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: Ainaz Mihanfar Faezeh Asghari Maryam Majidinia Source Type: research
Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response
CONCLUSION: The simultaneous treatment of resistant colorectal cancer cells with 5-FU and ATR inhibitor, VE-822, was demonstrated to be effective in reversing drug resistance and potentiating 5-FU mediated anticancer effects via targeting DNA damage.PMID:38553623 | DOI:10.1007/s11033-024-09431-7 (Source: Mol Biol Cell)
Source: Mol Biol Cell - March 30, 2024 Category: Molecular Biology Authors: Ainaz Mihanfar Faezeh Asghari Maryam Majidinia Source Type: research
Harmine alleviated STZ-induced rat diabetic nephropathy: A potential role via regulating AMPK/Nrf2 pathway and deactivating ataxia-telangiectasia mutated (ATM) signaling
Int Immunopharmacol. 2024 Mar 29;132:111954. doi: 10.1016/j.intimp.2024.111954. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) is a serious kidney disorder driven by diabetes and affects people all over the world. One of the mechanisms promoting NF-κB-induced renal inflammation and injury has been theorized to be ATM signaling. On the other hand, AMPK, which can be activated by the naturally occurring alkaloid harmine (HAR), has been proposed to stop that action. As a result, the goal of this study was to evaluate the therapeutic effectiveness of HAR against streptozotocin (STZ)-induced DN in rats through AMPK-me...
Source: International Immunopharmacology - March 30, 2024 Category: Allergy & Immunology Authors: Manar Mohammed El Tabaa Maram Mohammed El Tabaa Eman Rashad Mohammed Salah Elballal Ola Elazazy Source Type: research
Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response
CONCLUSION: The simultaneous treatment of resistant colorectal cancer cells with 5-FU and ATR inhibitor, VE-822, was demonstrated to be effective in reversing drug resistance and potentiating 5-FU mediated anticancer effects via targeting DNA damage.PMID:38553623 | DOI:10.1007/s11033-024-09431-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: Ainaz Mihanfar Faezeh Asghari Maryam Majidinia Source Type: research
Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response
CONCLUSION: The simultaneous treatment of resistant colorectal cancer cells with 5-FU and ATR inhibitor, VE-822, was demonstrated to be effective in reversing drug resistance and potentiating 5-FU mediated anticancer effects via targeting DNA damage.PMID:38553623 | DOI:10.1007/s11033-024-09431-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: Ainaz Mihanfar Faezeh Asghari Maryam Majidinia Source Type: research
Symptomatic infratentorial ependymal cyst arising from the medulla: a case report with review of literature
CONCLUSION: Due to their rarity and potential similarity to other cystic structures, EC may be overlooked or incorrectly diagnosed resulting in mismanagement and surgical disaster. Therefore, a comprehensive understanding and awareness of their distinct characteristics are essential for accurate diagnosis and appropriate management.PMID:38547561 | DOI:10.1016/j.neuchi.2024.101553 (Source: Neurochirurgie)
Source: Neurochirurgie - March 28, 2024 Category: Neurosurgery Authors: Julianna Cavallaro Souvik Singha Bhaskar Chakrabarti Eswar Gopalakrishnan Manju Harshan Bidyut Kumar Pramanik Amy McKeown John A Boockvar Source Type: research
Symptomatic infratentorial ependymal cyst arising from the medulla: a case report with review of literature
CONCLUSION: Due to their rarity and potential similarity to other cystic structures, EC may be overlooked or incorrectly diagnosed resulting in mismanagement and surgical disaster. Therefore, a comprehensive understanding and awareness of their distinct characteristics are essential for accurate diagnosis and appropriate management.PMID:38547561 | DOI:10.1016/j.neuchi.2024.101553 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - March 28, 2024 Category: Neurosurgery Authors: Julianna Cavallaro Souvik Singha Bhaskar Chakrabarti Eswar Gopalakrishnan Manju Harshan Bidyut Kumar Pramanik Amy McKeown John A Boockvar Source Type: research
Symptomatic infratentorial ependymal cyst arising from the medulla: a case report with review of literature
CONCLUSION: Due to their rarity and potential similarity to other cystic structures, EC may be overlooked or incorrectly diagnosed resulting in mismanagement and surgical disaster. Therefore, a comprehensive understanding and awareness of their distinct characteristics are essential for accurate diagnosis and appropriate management.PMID:38547561 | DOI:10.1016/j.neuchi.2024.101553 (Source: Neurochirurgie)
Source: Neurochirurgie - March 28, 2024 Category: Neurosurgery Authors: Julianna Cavallaro Souvik Singha Bhaskar Chakrabarti Eswar Gopalakrishnan Manju Harshan Bidyut Kumar Pramanik Amy McKeown John A Boockvar Source Type: research
Symptomatic infratentorial ependymal cyst arising from the medulla: a case report with review of literature
CONCLUSION: Due to their rarity and potential similarity to other cystic structures, EC may be overlooked or incorrectly diagnosed resulting in mismanagement and surgical disaster. Therefore, a comprehensive understanding and awareness of their distinct characteristics are essential for accurate diagnosis and appropriate management.PMID:38547561 | DOI:10.1016/j.neuchi.2024.101553 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - March 28, 2024 Category: Neurosurgery Authors: Julianna Cavallaro Souvik Singha Bhaskar Chakrabarti Eswar Gopalakrishnan Manju Harshan Bidyut Kumar Pramanik Amy McKeown John A Boockvar Source Type: research
Presentation of Wernicke encephalopathy in patient secondary to one anastomosis gastric bypass. Case report and literature review
We present the case of a postoperative patient with a one anastomosis gastric bypass with reoperation undergoing a Roux-en-Y gastric bypass that begins with confusion and nystagmus on her third postoperative day. The diagnosis of Wernicke encephalopathy is made by imaging, and vitamin B1 is administered with total improvement of nystagmus and altered state of consciousness (lethargy, bradypsychia, bradylalia).PMID:38537227 | DOI:10.24875/CIRU.21000706 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 27, 2024 Category: Surgery Authors: Luis F Zorrilla-N úñez Luis Tamez-Pedroza Patricio Dur án-Moreno Gerardo E Mu ñoz-Maldonado Source Type: research
Presentation of Wernicke encephalopathy in patient secondary to one anastomosis gastric bypass. Case report and literature review
We present the case of a postoperative patient with a one anastomosis gastric bypass with reoperation undergoing a Roux-en-Y gastric bypass that begins with confusion and nystagmus on her third postoperative day. The diagnosis of Wernicke encephalopathy is made by imaging, and vitamin B1 is administered with total improvement of nystagmus and altered state of consciousness (lethargy, bradypsychia, bradylalia).PMID:38537227 | DOI:10.24875/CIRU.21000706 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 27, 2024 Category: Surgery Authors: Luis F Zorrilla-N úñez Luis Tamez-Pedroza Patricio Dur án-Moreno Gerardo E Mu ñoz-Maldonado Source Type: research
