Resection of the quadrangular lobule of the cerebellum to increase exposure of the cerebellomesencephalic fissure: an anatomical study with clinical correlation
CONCLUSIONS: QLC resection significantly increased the exposure area, mainly in the anteroposterior axis. This surgical strategy appears to be safe and may help the neurosurgeon when operating on the lateral aspect of the cerebellomesencephalic fissure.PMID:38564813 | DOI:10.3171/2023.7.JNS222838 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 2, 2024 Category: Neurosurgery Authors: Juan Leonardo Serrato-Avila Juan Alberto Paz Archila Alejandro Monroy-Sosa Sebastian An íbal Alejandro Marcos Devanir Silva da Costa Sergio Cavalheiro Kaan Yagmurlu Michael T Lawton Feres Chaddad-Neto Source Type: research
Resection of the quadrangular lobule of the cerebellum to increase exposure of the cerebellomesencephalic fissure: an anatomical study with clinical correlation
CONCLUSIONS: QLC resection significantly increased the exposure area, mainly in the anteroposterior axis. This surgical strategy appears to be safe and may help the neurosurgeon when operating on the lateral aspect of the cerebellomesencephalic fissure.PMID:38564813 | DOI:10.3171/2023.7.JNS222838 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - April 2, 2024 Category: Neurosurgery Authors: Juan Leonardo Serrato-Avila Juan Alberto Paz Archila Alejandro Monroy-Sosa Sebastian An íbal Alejandro Marcos Devanir Silva da Costa Sergio Cavalheiro Kaan Yagmurlu Michael T Lawton Feres Chaddad-Neto Source Type: research
DNA Damage-driven Inflammatory Cytokines: Reprogramming of Tumor Immune Microenvironment and Application of Oncotherapy
AbstractDNA damage occurs across tumorigenesis and tumor development. Tumor intrinsic DNA damage can not only increase the risk of mutations responsible for tumor generation but also initiate a cellular stress response to orchestrate the tumor immune microenvironment (TIME) and dominate tumor progression. Accumulating evidence documents that multiple signaling pathways, including cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) and ataxia telangiectasia-mutated protein/ataxia telangiectasia and Rad3-related protein (ATM/ATR), are activated downstream of DNA damage and they are associated with the secreti...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - April 2, 2024 Category: Research Source Type: research
Effect of Regional Brain Activity Following Repeat Transcranial Magnetic Stimulation in SCA3: A Secondary Analysis of a Randomized Clinical Trial
This study aims to observe the short-term impact of cerebellar rTMS on motor function in SCA3 patients and utilize resting-state functional magnetic resonance imaging (RS-fMRI) to assess potential therapeutic mechanisms. Twenty-two SCA3 patients were randomly assigned to receive actual rTMS (AC group, n = 11, three men and eight women; age 32-55 years) or sham rTMS (SH group, n = 11, three men and eight women; age 26-58 years). Both groups underwent cerebellar rTMS or sham rTMS daily for 15 days. The primary outcome measured was the ICARS scores and parameters for regional brain activity. Compared to baseline, ICARS scores...
Source: Cerebellum - April 1, 2024 Category: Neuroscience Authors: Xia Liu Lin Zhang Hao-Lin Xu Xia-Hua Liu Arif Sikandar Meng-Cheng Li Xiao-Yue Xia Zi-Qiang Huang Na-Ping Chen Yu-Qing Tu Jian-Ping Hu Shi-Rui Gan Qun-Lin Chen Xin-Yuan Chen Shi-Zhong Wang Members of the Organization in South-East China for Cerebellar Atax Source Type: research
Effect of Regional Brain Activity Following Repeat Transcranial Magnetic Stimulation in SCA3: A Secondary Analysis of a Randomized Clinical Trial
This study aims to observe the short-term impact of cerebellar rTMS on motor function in SCA3 patients and utilize resting-state functional magnetic resonance imaging (RS-fMRI) to assess potential therapeutic mechanisms. Twenty-two SCA3 patients were randomly assigned to receive actual rTMS (AC group, n = 11, three men and eight women; age 32-55 years) or sham rTMS (SH group, n = 11, three men and eight women; age 26-58 years). Both groups underwent cerebellar rTMS or sham rTMS daily for 15 days. The primary outcome measured was the ICARS scores and parameters for regional brain activity. Compared to baseline, ICARS scores...
Source: Cerebellum - April 1, 2024 Category: Neuroscience Authors: Xia Liu Lin Zhang Hao-Lin Xu Xia-Hua Liu Arif Sikandar Meng-Cheng Li Xiao-Yue Xia Zi-Qiang Huang Na-Ping Chen Yu-Qing Tu Jian-Ping Hu Shi-Rui Gan Qun-Lin Chen Xin-Yuan Chen Shi-Zhong Wang Members of the Organization in South-East China for Cerebellar Atax Source Type: research
Effect of Regional Brain Activity Following Repeat Transcranial Magnetic Stimulation in SCA3: A Secondary Analysis of a Randomized Clinical Trial
This study aims to observe the short-term impact of cerebellar rTMS on motor function in SCA3 patients and utilize resting-state functional magnetic resonance imaging (RS-fMRI) to assess potential therapeutic mechanisms. Twenty-two SCA3 patients were randomly assigned to receive actual rTMS (AC group, n = 11, three men and eight women; age 32-55 years) or sham rTMS (SH group, n = 11, three men and eight women; age 26-58 years). Both groups underwent cerebellar rTMS or sham rTMS daily for 15 days. The primary outcome measured was the ICARS scores and parameters for regional brain activity. Compared to baseline, ICARS scores...
Source: Cerebellum - April 1, 2024 Category: Neuroscience Authors: Xia Liu Lin Zhang Hao-Lin Xu Xia-Hua Liu Arif Sikandar Meng-Cheng Li Xiao-Yue Xia Zi-Qiang Huang Na-Ping Chen Yu-Qing Tu Jian-Ping Hu Shi-Rui Gan Qun-Lin Chen Xin-Yuan Chen Shi-Zhong Wang Members of the Organization in South-East China for Cerebellar Atax Source Type: research
Effect of Regional Brain Activity Following Repeat Transcranial Magnetic Stimulation in SCA3: A Secondary Analysis of a Randomized Clinical Trial
This study aims to observe the short-term impact of cerebellar rTMS on motor function in SCA3 patients and utilize resting-state functional magnetic resonance imaging (RS-fMRI) to assess potential therapeutic mechanisms. Twenty-two SCA3 patients were randomly assigned to receive actual rTMS (AC group, n = 11, three men and eight women; age 32-55 years) or sham rTMS (SH group, n = 11, three men and eight women; age 26-58 years). Both groups underwent cerebellar rTMS or sham rTMS daily for 15 days. The primary outcome measured was the ICARS scores and parameters for regional brain activity. Compared to baseline, ICARS scores...
Source: Cerebellum - April 1, 2024 Category: Neuroscience Authors: Xia Liu Lin Zhang Hao-Lin Xu Xia-Hua Liu Arif Sikandar Meng-Cheng Li Xiao-Yue Xia Zi-Qiang Huang Na-Ping Chen Yu-Qing Tu Jian-Ping Hu Shi-Rui Gan Qun-Lin Chen Xin-Yuan Chen Shi-Zhong Wang Members of the Organization in South-East China for Cerebellar Atax Source Type: research
Effect of Regional Brain Activity Following Repeat Transcranial Magnetic Stimulation in SCA3: A Secondary Analysis of a Randomized Clinical Trial
This study aims to observe the short-term impact of cerebellar rTMS on motor function in SCA3 patients and utilize resting-state functional magnetic resonance imaging (RS-fMRI) to assess potential therapeutic mechanisms. Twenty-two SCA3 patients were randomly assigned to receive actual rTMS (AC group, n = 11, three men and eight women; age 32-55 years) or sham rTMS (SH group, n = 11, three men and eight women; age 26-58 years). Both groups underwent cerebellar rTMS or sham rTMS daily for 15 days. The primary outcome measured was the ICARS scores and parameters for regional brain activity. Compared to baseline, ICARS scores...
Source: Cerebellum - April 1, 2024 Category: Neuroscience Authors: Xia Liu Lin Zhang Hao-Lin Xu Xia-Hua Liu Arif Sikandar Meng-Cheng Li Xiao-Yue Xia Zi-Qiang Huang Na-Ping Chen Yu-Qing Tu Jian-Ping Hu Shi-Rui Gan Qun-Lin Chen Xin-Yuan Chen Shi-Zhong Wang Members of the Organization in South-East China for Cerebellar Atax Source Type: research
Bilateral vestibulopathy as the initial presentation of CANVAS
Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is a slowly progressing autosomal recessive ataxic disorder linked to an abnormal biallelic intronic (most commonly) AAGGG repeat expansion in the replication factor complex subunit 1 (RFC1). While the clinical diagnosis is relatively straightforward when the three components of the disorder are present, it becomes challenging when only one of the triad (cerebellar ataxia, neuropathy or vestibular areflexia) manifests. Isolated cases of Bilateral Vestibulopathy (BVP) or vestibular areflexia that later developed the other components of CANVAS have ...
Source: Journal of the Neurological Sciences - April 1, 2024 Category: Neurology Authors: Carlos R. Gordon, Roy Zaltzman, Dario Geisinger, Zohar Elyoseph, Yoav Gimmon Tags: Clinical short communication Source Type: research
Neuroimaging mechanisms of low-frequency repetitive transcranial magnetic stimulation for treatment of SCA3/MJD: a double-blind randomized sham-controlled trial
To investigate the efficacy and mechanism of low-frequency Repetitive transcranial magnetic stimulation (rTMS) in patients with Spinocerebellar ataxia type 3/Machado-Joseph Disease (SCA3/MJD). (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - April 1, 2024 Category: Rehabilitation Authors: Xin-Yuan Chen, Lin zhang, Yan-Hua Lian, Jun Ni Tags: Oral Presentation 2584223 Source Type: research
Gait Characteristics in Spinocerebellar Ataxia Type 3 Assessed Using Wearable Sensors
To investigate a set of gait variability from lower limb wearable sensors that best discriminate between people with healthy or manifest spinocerebellar ataxia (SCA) type 3 and determine how these measures relate to disease severity. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - April 1, 2024 Category: Rehabilitation Authors: Xin-Yuan Chen Tags: Research Poster 2522480 Source Type: research
Modern wobble expenses: a scoping review of ataxia rehabilitation interventions of the past fifteen years with cost impact discussion
To identify recent ataxia interventions and investigate cost-utility for patients with ataxia. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - April 1, 2024 Category: Rehabilitation Authors: Elizabeth Garcia, Melissa Vasquez, Nimotallah Abdurrazaq Tags: Late Breaking Systematic & Meta-analytic Review Poster 2552223 Source Type: research
Retinal End Points for ATXN7- Related Spinocerebellar Ataxia
Inherited neurological degenerations often involve the retina, including the spinocerebellar ataxias, a group of diseases that cause progressive neurological degeneration including ataxia. Even before neurological symptoms develop, patients often experience oculomotor and retinal abnormalities, including degeneration of cone and rod photoreceptors and degeneration of the optic nerve. Because SCA7 is autosomal dominant, asymptomatic family members could be identified genetically at presymptomatic stages, and treatments could be administered before degeneration caused irreversible loss of function. As potential treatments to...
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
ATXN7 -Related Cone-Rod Dystrophy
This study describes baseline ophthalmological biomarkers in spinocerebellar ataxia type 7 carriers included in the Integrated Functional Evaluation of the Cerebellum (CERMOI) cross-sectional study. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response
CONCLUSION: The simultaneous treatment of resistant colorectal cancer cells with 5-FU and ATR inhibitor, VE-822, was demonstrated to be effective in reversing drug resistance and potentiating 5-FU mediated anticancer effects via targeting DNA damage.PMID:38553623 | DOI:10.1007/s11033-024-09431-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 30, 2024 Category: Molecular Biology Authors: Ainaz Mihanfar Faezeh Asghari Maryam Majidinia Source Type: research
