A 40-something healthy male with transient chest squeezing
A 40-something man with Hx of treated HTN had chest " squeezing, " with SOB and diaphoresis, 10 hours prior to presentation. It lasted 5 minutes then resolved. There was an exertional component. Then, 1 hour before arrival, it recurred, again lasting 5 minutes. His 3rd and last episode was worse, had radiation to both arms, and was 10/10. 911 was called and this prehospital ECG was recorded at time zero:Limb leads:Note the artifact that is simultaneously recorded in all limb leads. This was mistaken by the treating physicians for ST depression initially.Precordial leads:What do you t...
Source: Dr. Smith's ECG Blog - September 21, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
The “ World anti-platelet ” boxing championship 2019 !
Conclusions in science is a misnomer . . . )
(Source: Dr.S.Venkatesan MD)
Source: Dr.S.Venkatesan MD - September 20, 2019 Category: Cardiology Authors: dr s venkatesan Tags: anti platelet drug anti platelet drugs antiplatelet guidleines acc aha esc clopidogrel dapt mapt ISAR REACT PLATO trial prasugrel THEMIS TRIAL ticagrelor triton timi 38 treat plato twilight trial Source Type: blogs
Matthew O'Connor Presenting on Underdog Pharmaceuticals at Undoing Aging 2019
Here Matthew O'Connor of the SENS Research Foundation talks about the research that led to founding of Underdog Pharmaceuticals, a biotech startup incubated by the foundation to commercialize a means of targeting 7-ketocholesterol in atherosclerosis and other conditions. Oxidized cholesterols, and largely 7-ketocholesterol, are the primary cause of dysfunction in the macrophage cells normally responsible for preventing the build up of fatty plaques in blood vessel walls. That dysfunction is the cause of atherosclerosis, and the fact that the presence of oxidized cholesterols increases with age is one of the reasons why ath...
Source: Fight Aging! - September 16, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, September 16th 2019
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial.
People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - September 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aspirin Use Fails to Postpone Disability and Improve Survival in Older Individuals
Aspirin is arguably a calorie restriction mimetic, in that it boosts the operation of the cellular maintenance processes of autophagy to some degree. Increased autophagy is a feature of many of the interventions, such as calorie restriction, that slow aging in various animal models. Aspirin can extend life in short-lived species. The fact that an ongoing trial shows it to do no such thing in humans is just one more of the many pieces of evidence to demonstrate that short-lived and long-lived species have a very different plasticity of longevity in response to upregulation of stress response systems such as autophagy. The e...
Source: Fight Aging! - September 9, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Leg pain when you walk? Don ’t ignore it
Walking is often touted as a perfect exercise to improve multiple aspects of health. But what if walking causes leg pain? Many people shrug off leg pain when they walk as a normal part of aging. In some cases, though, it’s the sign of peripheral artery disease (PAD), which can put heart and brain health at risk. While PAD doesn’t usually run in families, it’s more likely to occur as people age, or among people who smoke or have high blood pressure, high cholesterol, or diabetes.
What causes leg pain if you have PAD?
People with PAD have fatty deposits in arteries outside the heart — most often in their legs. Pain o...
Source: Harvard Health Blog - September 6, 2019 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Exercise and Fitness Healthy Aging Heart Health Hypertension and Stroke Pain Management Source Type: blogs
Everybody Seems to be an Expert, Except Your Family Doctor?
By HANS DUVEFELT, MD
It’s a funny world we live in. Lots of people make a handsome living, defining their work and setting their own fees and hours with little or no formal education or certification
There are personal and executive coaches, wealth advisers, marketing experts, closet organizers and all kinds of people offering to help us run our lives.
In each of these fields, the expectation is that the provider of such services has his or her own “take” or perspective and offers advice that is individual, unique and as far removed from cookie cutter dogma as possible. Why pay for something generic that lot...
Source: The Health Care Blog - September 2, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Family medicine Hans Duvefelt Source Type: blogs
Fight Aging! Newsletter, September 2nd 2019
In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise.
Methods of Inducing Cellular Damage are Rarely Relevant to Aging, and the Details Matter
https://www.fightaging.org/archives/2019/08/methods-of-inducing-cellular-damage-are-rarely-relevant-to-aging-and-the-details-matter/
One of the major challenges in aging research is determining whether or not models of cellular or organismal damage and its consequences are in any way relevant to the natural processes of aging. One can hit a brick wit...
Source: Fight Aging! - September 1, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Large Polypill Clinical Trial Shows a Third Reduction in Cardiovascular Events
The research and medical communities are slow to undertake work on combination therapies. Regulation makes it exceedingly expensive to assess multiple combinations, and there are numerous other perverse incentives to challenge any effort to build combination therapies with components developed and manufactured by different groups. Short of working around the existing system of regulation, and methods of doing this at scale are lacking at the present time, this is a challenging problem to solve. People follow incentives. Given this, it it is entirely plausible that there are many largely unexplored instances in which existi...
Source: Fight Aging! - August 30, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Possible Way to Avoid Some Unnecessary Visits to Emergency Departments
I recently encountered an article that quantifies the resources expended by unnecessary patient visits to emergency departments (EDs) (see:Diverting avoidable emergency department visits could save healthcare $32 billion annually). Many such visits could have achieved the same results and less expensively in a physician's office. Below is an excerpt from the article:Diverting avoidable emergency department visits could save healthcare $32 billion annually. Primary care services rendered by hospital EDs come with substantially higher price tags than in primary care settings. Avoidable visits to emergency departmen...
Source: Lab Soft News - August 5, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Cost of Healthcare Diagnostics Healthcare Information Technology Healthcare Innovations Hospital Financial Medical Consumerism Medical Education Preventive Medicine Public Health Quality of Care Source Type: blogs
OMI Confirmed by POCUS Echo in a 50 year man
Case submitted and written by Alex BraceyA man in his 50s with no significant past medical history presented from a local beach with epigastric " burning " pain that had been intermittent for 4 days until this morning when it became constant at rest. He had associated nausea and diaphoresis, but overall looked well and had arrived by private vehicle to front triage. An ECG was performed there and brought to me for review:What do you think?STE in V2-4 that might just barely meet STEMI criteriaSTE in aVL, and to a lesser extent lead IObvious reciprocal STD in II, III, aVFRegardless of whether this ECG truly meets STEMI crite...
Source: Dr. Smith's ECG Blog - August 1, 2019 Category: Cardiology Authors: Pendell Source Type: blogs
Kidney stones: What are your treatment options?
If you’ve been diagnosed with kidney stones (urolithiasis), you may have several options for treatment. These include medical therapy, extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotripsy (PCNL), and ureteroscopy.
A brief anatomy of the urinary tract
The urinary tract includes
kidneys (two organs that filter waste and extra water from the blood)
ureters (two tubes bringing urine from each kidney to the bladder)
bladder (organ that collects urine)
urethra (a single tube through which urine in the bladder passes out of the body).
The evaluation for kidney stones
If your symptoms suggest kidney sto...
Source: Harvard Health Blog - July 18, 2019 Category: Consumer Health News Authors: Kevin R. Loughlin, MD, MBA Tags: Kidney and urinary tract Men's Health Women's Health Source Type: blogs
A Text Message in the Middle of the night. Do you give thrombolytics?
I awoke in the morning and discovered a text with this ECG that was sent 6 hours prior by a former resident:" 60 year old with classic chest pain. The cath lab is occupied for the next 90 minutes. Cards says " not a STEMI " . Thinking of giving lytics. "What do you think?What do you do?I texted back: " Sorry for delay! Was sleeping. This is OMI!! Did you give lytics? Proximal LAD. Great catch! "There is 0.5 mm of ST Elevation in V3-V6. The T-wave in V4 is far too large for the QRS. The LAD occlusion formula would be very high due to the extremely small R-wave in V...
Source: Dr. Smith's ECG Blog - July 16, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
Landmark Results Achieved in Aging and Chronic Disease: Danish Group Extends Disease-free Life by 8 Years
By WILLIAM H. BESTERMANN JR., MD
New Scientific Breakthroughs Can
Provide a Longer Healthier Life
Twenty-one years of follow-up comparing usual care with a protocol-driven team-based intervention in diabetes proved that healthy life in humans can be prolonged by 8 years. These results were achieved at a lower per patient per year cost. Aging researchers have been confident that we will soon be able to prolong healthy life. This landmark study shows this ambitious goal can be achieved now with lifestyle intervention and a few highly effective proven medications. These medications interfere with the core molecular biol...
Source: The Health Care Blog - July 11, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Patients aging chronic disease Denmark Diabetes William Bestermann Source Type: blogs
Colorectal cancer screening before age 50?
Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. There is strong evidence that screening for CRC with colonoscopy, other visual exams, or stool-based tests can reduce CRC mortality. As a result, several expert organizations have long recommended regular CRC screening for US adults ages 50 to 75.
In 2018, the American Cancer Society (ACS) became the first major organization to recommend CRC screening starting at 45.
Why did the ACS recommend CRC screening starting at 45?
The incidence of CRC and mortality from the disease has declined over the last several decades among adults over 5...
Source: Harvard Health Blog - June 28, 2019 Category: Consumer Health News Authors: Andrew Chan, MD, MPH Tags: Cancer Health Prevention Screening Tests and procedures Source Type: blogs
