Growing Enthusiasm for the Development of Geroprotectors
A geroprotector is a drug or supplement that either slows the underlying causes of aging or produces a greater resistance to the damage of aging. In either case health is prolonged and mortality decreased. Calorie restriction mimetics are the best example of the type, but the category is expansive enough to include well known drugs such as aspirin. As you might imagine of a class of treatments that includes aspirin, the size of effect when it comes to additional years of life is fairly small, even in those cases in which the benefits are reliable. Geroprotectors largely work through upregulation of stress responses, someth...
Source: Fight Aging! - November 15, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Timing of revascularization in patients with transient STEMI: a randomized clinical trial
This study shows that for a transient STEMI ( " complete normalization of ST segments " ), it is not unequivocally necessary to activate the cath lab emergently. This might extend to Wellens ' syndrome, which is really and transient STEMI in which the ST Elevation is not recorded.In this trial, 142 patients with transient STEMI were randomized to emergent vs. next day angiogram with PCI. MRI measure infarct size was the same in both. All patients received aspirin, a P2Y12 inhibitor, and an anticoagulant.However, andthis is a big however,4 patients in the delayed group had recurrent ischemia and needed...
Source: Dr. Smith's ECG Blog - November 1, 2018 Category: Cardiology Authors: Steve Smith Source Type: blogs
Live the Wheat Belly lifestyle, get off prescription medications
Take a look at the list of medications people have been able to stop by following the Wheat Belly lifestyle.
These represent medications prescribed by doctors to, in effect, “treat” the consequences of consuming wheat and grains. They prescribe drugs to treat inflammation, swelling, skin rashes, gastrointestinal irritation, high blood sugars, airway allergy, joint pain, high blood pressure, leg edema and other abnormal effects caused by wheat and grains.
The list includes anti-inflammatory and pain medication, acid reflux drugs, injectable and oral drugs for diabetes, numerous anti-hypertensive agents, asthma i...
Source: Wheat Belly Blog - October 27, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates autoimmune blood sugar bowel flora cholesterol Gliadin gluten-free grain-free grains Inflammation undoctored Weight Loss wheat belly Source Type: blogs
Our residents are getting really good at this.
Conclusion:This patient was treated so fast that he had no actual infarction. Spontaneous reperfusion certainly helped.So this is really another case ofUnstable Angina. Here are more cases of Unstable Angina (Source: Dr. Smith's ECG Blog)
Source: Dr. Smith's ECG Blog - October 27, 2018 Category: Cardiology Authors: Steve Smith Source Type: blogs
New evidence that the “chaotic mind” of ADHD brings creative advantages
Participant drawings from White, 2018
By Christian Jarrett
Focus and concentration, while normally considered beneficial attributes, can stymie creativity – especially the generation of novel ideas. This has led some to wonder whether people with “leaky attention“, and especially those with ADHD – who have what Holly White, writing recently in the Journal of Creative Behaviour, calls “chaotic minds” – might have a creative advantage when it comes to breaking free from prior examples. White, who is based at the University of Michigan, has tested this possibility, and though she acknowledges h...
Source: BPS RESEARCH DIGEST - October 19, 2018 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: ADHD Creativity Source Type: blogs
Anterior STEMI and multiform PVCs with Narrow Coupling Interval. When to give beta blockers in acute MI?
Conclusion of first report:In patients with anterior Killip class II or less ST-segment –elevation myocardial infarction undergoing primary percutaneous coronary intervention, early intravenous metoprolol before reperfusion reduced infarct size and increased left ventricular ejection fraction with no excess of adverse events during the first 24 hours after STEMI.Conclusion of 2nd report: In patients with anterior Killip class ≤II STEMI undergoing pPCI, early IV metoprolol before reperfusion resulted in higher long-term LVEF, reduced incidence of severe LV systolic dysfunction and ICD indications, and fewer h...
Source: Dr. Smith's ECG Blog - October 19, 2018 Category: Cardiology Authors: Steve Smith Source Type: blogs
Primary care does what Google can ’t
Non-clinicians skip over some of the most necessary underpinnings of doctoring and speak too much about housekeeping issues: blood pressure targets, aspirin use, mass screenings, immunization rates and so on.
People without medical degrees could do those things. But there are steps that must be taken before we worry about the measurables. These are the essence of being a physician, what people ask for when they come to see us. Most people don’t come in and say, “I need you to regulate my blood pressure,” or “Help me lower my cholesterol.” They come in saying, “I don’t feel good,” or “Help me stay healthy....
Source: Kevin, M.D. - Medical Weblog - October 14, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/a-country-doctor" rel="tag" > A Country Doctor, MD < /a > Tags: Physician Primary Care Source Type: blogs
Fight Aging! Newsletter, October 15th 2018
This study suggests that exocrine glands can be induced from pluripotent stem cells for organ replacement regenerative therapy.
Replacement of Aged Microglia Partially Reverses Cognitive Decline in Mice
https://www.fightaging.org/archives/2018/10/replacement-of-aged-microglia-partially-reverses-cognitive-decline-in-mice/
Researchers here report on a compelling demonstration that shows the degree to which dysfunctional microglia contribute to age-related neurodegeneration. The scientists use a pharmacological approach to greatly deplete the microglial population and then allow it to recover naturally. Th...
Source: Fight Aging! - October 14, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Few More Reasons Not to Become Overweight and Obese
Being obese or overweight is, for the overwhelming majority of such individuals, a choice. There is plenty of ink spilled over how hard or easy the choice of body weight is to make, but it is nonetheless a choice. Want to weigh less? Then persist in eating fewer calories in the context of a sanely balanced diet. It really is as simple as that. The only way to fail is to fail to eat fewer calories. That this is eternally a challenge, and that obesity is increasingly prevalent in an environment of cheap calories, tells us more about human nature than it does about our biology.
The present consensus on the effects of e...
Source: Fight Aging! - October 11, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Aspirin for primary prevention of cardiovascular disease, part 2
Well, it seems as though not even a week can go by without more data on aspirin! I recently reviewed the ARRIVE trial and the implications for primary prevention — that is, trying to prevent heart attacks and strokes in otherwise healthy people. Since then, yet another large clinical trial — the ASPREE study — has come out questioning the use of aspirin in primary prevention. Three articles pertaining to this trial were published in the prestigious New England Journal of Medicine, which is an unusual degree of coverage for one trial and highlights its immediate relevance to clinical practice.
Aspirin still strongly i...
Source: Harvard Health Blog - September 25, 2018 Category: Consumer Health News Authors: Deepak Bhatt, MD, MPH Tags: Heart Health Prevention Source Type: blogs
Aspirin for primary prevention of cardiovascular disease?
This study did find a significant reduction in adverse cardiovascular outcomes with daily aspirin in people with diabetes, though there was also a similar magnitude of increased major bleeding. Still, many people would rather be hospitalized for bleeding and get a transfusion versus being hospitalized for a heart attack that causes permanent damage to the heart. Others may not see much difference between the two types of events and may prefer not to take an additional medication.
Should you take a daily aspirin?
So, where does this leave the average person who is worried about a heart attack and wants to do everything they...
Source: Harvard Health Blog - September 20, 2018 Category: Consumer Health News Authors: Deepak Bhatt, MD, MPH Tags: Heart Health Source Type: blogs
Salicylates as an Autophagy Based Approach to Modestly Slow Aging in Nematodes
A sizable fraction of the many methods demonstrated to slow aging and increase longevity in nematode worms involve increased levels of autophagy. This collection of cellular maintenance and recycling mechanisms becomes more active following any sort of cellular stress, from heat to toxicity to lack of nutrients. Life span in short lived species is highly plastic in response to environmental circumstances; any minor stress can produce a net benefit. This can make it somewhat challenging to determine whether any particular approach shown to slow aging is in fact acting directly or indirectly via the controlling mechanisms of...
Source: Fight Aging! - September 20, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Daily Low Dose Aspirin Fails to Extend Healthy Life Spans in Older Patients
Aspirin is arguably a calorie restriction mimetic, able to spur some of the same beneficial cellular stress responses that are activated by low nutrient levels. Calorie restriction itself, practiced over the long term, does not have a very large effect on human life span. Given the existing demographic data, a gain of even five years of life would be very surprising. Further, it is well established that the life extension resulting from calorie restriction scales down as species life span scales up. Mice live up to 40% longer on calorie restricted diets, but we humans certainly don't.
Aspirin has other effects besid...
Source: Fight Aging! - September 18, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Aspirin: Panacea or Piffle?
Aspirin is once again in the headlines, prompted by New England Journal of Medicine reports suggesting that people aged 70 years and older obtain no benefit and perhaps experience harm in the form of increased bleeding and increased death from cancer on low-dose aspirin. This adds to the decades-long debate on whether aspirin is beneficial as a preventive measure against cardiovascular events such as heart attack in which a blood clot forms on top of inflamed atherosclerotic plaque in the coronary arteries. Unlike many other studies that are observational and therefore virtually useless, these studies are prospective and r...
Source: Wheat Belly Blog - September 17, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates aspirin coronary grain-free heart attack heart disease Inflammation platelets Weight Loss wheat belly Source Type: blogs
A completely healthy 30-something woman with acute chest pain -- this post is loaded with info !!!
p.p1 {margin: 0.1px 0.0px 0.1px 0.2px; font: 11.0px Helvetica}A previously healthy young woman presented to the ED with one hour of acute onset right sided chest pain and pressure, very severe, radiating down the right arm. Here is her initial ED ECG (time 0):What do you think?My impression:without any other information, I looked at this ECG and 2 features stood out: 1) the T-wave in lead I is hyperacute. It is far too large for that QRS. 2) The T-wave in V6 is far too large; it is almost as tall as the R-wave, which is distinctly abnormal. 3) there is slight downsloping ST depression in V2 whi...
Source: Dr. Smith's ECG Blog - September 15, 2018 Category: Cardiology Authors: Steve Smith Source Type: blogs
