A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
The market has been in the doldrums and it has been a tough year for fundraising, both for non-profits and biotech startups. The conferences have exhibited more of an academic focus as companies tightened belts and postponed investment rounds, while investors stayed home. Not that this halts the flow of hype for some projects, and nor has it slowed media commentary on the longevity industry as it presently stands. A few of the articles in that commmentary are even interesting to read! The field has grown and is more mature now than has ever been the case. Biotech of all forms is a challenging field with a high failure rate...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Acute OMI or " Benign " Early Repolarization?
Written by Willy FrickA man in his 50s with a history of hypertension, dyslipidemia, type 2 diabetes mellitus, and prior inferior OMI status post DES to his proximal RCA 3 years prior presented to the emergency department at around 3 AM complaining of chest pain onset around 9 PM the evening prior. He described it as severe, sharp, and substernal with associated nausea, vomiting, chills, and diaphoresis. The following ECG was obtained. Note that the machine read is" normal sinus rhythm, normal ECG. " Cardiology over read the tracing and signed the interpretation without modification.ECG 1What do you think?The Queen of Hear...
Source: Dr. Smith's ECG Blog - December 27, 2023 Category: Cardiology Authors: Willy Frick Source Type: blogs
Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
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Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Meta-Analysis Suggests Aspirin Use Reduces Risk of Cancer Mortality
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
Link: https://doi.org/10.1038/s41416-023-02506-5 (Source: Fight Aging!)
Source: Fight Aging! - December 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Occlusion myocardial infarction is a clinical diagnosis
Written by Willy Frick (@Willyhfrick). Willy is a cardiology fellow with a keen interest in the ECG in OMI.A woman in her late 70s presented with left arm pain. The arm pain started the day prior when she was at the dentist ' s office for a root canal. Her systolic blood pressure at the dentist was over 200 mm Hg. She was given nitroglycerin which improved her blood pressure, and she completed the procedure. Her arm pain abated. The pain returned that evening and woke her from sleep. She eventually fell back asleep, and woke up feeling normal the next day (the day of presentation). After dinner the day of presentatio...
Source: Dr. Smith's ECG Blog - December 11, 2023 Category: Cardiology Authors: Willy Frick Source Type: blogs
Syncope While Driving. Activate the Cath Lab?
A 50-something had syncope while driving. He was belted and it was low speed. He had a prehospital ECG. He was ambulatory at the scene. He has a history of STEMI and heart failure. The medics stated he had been nauseated and diaphoretic, but he did not have any chest pain or SOB. They recorded a prehospital ECG:What do you think?I read this blinded, with no clinical information, and read it as inferior OMI. There is STE in inferior leads with a large T-wave and reciprocal ST depression in aVL with a reciprocally inverted T-wave. It is all but diagnostic of OMI. The on...
Source: Dr. Smith's ECG Blog - December 9, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Infection and DKA, then sudden dyspnea while in the ED
To learn more about Occlusion MI, join us in thisFree Webinar on November 27 12 noon US Central Time:Sign up at this link: https://zoom.us/webinar/register/2216945975176/WN_7HuMRHNxREKifGgQvy70lg#/registrationInfection and DKA, then sudden dyspnea while in the EDA 63 year old male with a PMH of CAD and peripheral vascular disease from type 1 DM presented to clinic and was found to have a very high blood sugar and so was sent to the emergency department.Patient stated that he has had glucose over 400 even though he has not missed any doses of insulin. He also endorses fatigue, upset stomach, frequent urination, i...
Source: Dr. Smith's ECG Blog - November 22, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
What does the angiogram show? The Echo? The CT coronary angiogram? How do you explain this?
A 70-something female with no previous cardiac history presented with acute chest pain. She awoke from sleep last night around 4:45 AM (3 hours prior to arrival) with pain that originated in her mid back. She stated the pain was achy/crampy. Over the course of the next hour, this pain turned into a pressure in her chest. She said this was midsternal and felt like a tightness. This originally radiated into her left arm. Over some time and the pain moved into her other arm as well as her jaw. She also had some shortness of breath. She was brought in by ambulance and re...
Source: Dr. Smith's ECG Blog - November 15, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
See this " NSTEMI " go unrecognized for what it really is, how it progresses, and what happens
Written by Nathanael Franks MD, reviewed by Meyers, Smith, Grauer, etc.A man in his 70s with past medical history of hypertension, dyslipidemia, CAD s/p left circumflex stent 2 years prior presented to the ED with worsening intermittent exertional chest pain relieved by rest. This episode of chest pain began 3 hours ago and was persistent even at rest.Triage ECG at Time = 0: Smith: I am suspicious for posterior OMI due to ST depression in V2 and V3Baseline EKG (several months prior):Smith: Now I am even more suspicious of posterior OMI, as the baseline ECG has normal ST elevation in V2 and V3ECG Interpretation:The tri...
Source: Dr. Smith's ECG Blog - November 3, 2023 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, October 30th 2023
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
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Source: Fight Aging! - October 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Sizable Mortality Risk Differences for Healthy versus Unhealthy Lifestyles in Later Life
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
Link: https://doi.org/10.1186/s12877-023-04247-9 (Source: Fight Aging!)
Source: Fight Aging! - October 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Proportionality and Serial ECGs Make the Diagnosis. What does the Queen say?
This case comes from Jason Winter, of The Facebook Clinical Electrocardiology ECG Page.
A 60-something woman called EMS for chest pain.
Here is her first prehospital ECG:What do you think?There is very low voltage in the precordial leads, with a total QRS amplitude of only 3.5 mm in V2 and 4 mm in V3. In spite of this low voltage, there is ST elevation (as measured at the J-point and relative to the PQ junction, and as measured by the computer and shown on the right), of 0.54 mm in V2 and0.65 mm in V3. The ST/QRS ratios in V2 and V3 are, respectively, 0.154 and 0.162. These are a hi...
Source: Dr. Smith's ECG Blog - September 29, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
What's new in midwifery - 13th September 2023 - Research
First, some original research that it might be useful to know about:Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix: The TOPS Randomized Clinical Trial. Effectiveness and Costs of Molecular Screening and Treatment for Bacterial Vaginosis to Prevent Preterm Birth: The AuTop Randomized Clinical Trial. Group vs Individual Prenatal Care and Gestational Diabetes Outcomes: A Secondary Analysis of a Randomized Clinical Trial. Mid-trimester uterine artery Doppler for aspirin discontinuation in pregnancies at high risk for preterm pre-eclampsia: Post-hoc analysis ...
Source: Browsing - September 14, 2023 Category: Databases & Libraries Tags: midwifery Source Type: blogs
All the Lonely People: Primary Care isn ’t a Team Sport Anymore, We’re Only Interacting with Our Computers
BY HANS DUVEFELT
In spite of all the talk these days about health care teams and in spite of more and more physicians working for bigger and bigger healthcare organizations, we are becoming more and more isolated from our colleagues and our support staffs.
Computer work, which is taking more and more time as EMRs get more and more complex, is a lonely activity. We are not just encouraged but pretty much forced to communicate with our nurses and medical assistants through computer messaging. This may provide more evidence of who said or did what at what point in time, but it is both inefficient and dehumanizing.
Wh...
Source: The Health Care Blog - September 7, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice EMR Hans Duvefelt primary care Professional Isolation Social Isolation Source Type: blogs
New ESC 2023, ACS guidelines : “ STEMI merges with NSTEMI ” for some good reasons.
Is it a STEMI or Non -STEMI ? The apparently realistic dichotomous thinking about ACS among physicians has existed for quite a long time. However, since the underlying pathobiology being same , it is worth wondering whether the conventional bifurcation of ACS is fool -proof , when applied to management decsions. The rapidity and totality of plaque fissusre, rupture eruption,or erosion and the subsequent response of the local hemorheological system, determine the ferocity of the event.
How to recognise all these deep intracellular events in bed side ? Unfortunately, still with a lot of gratitude, we have to rely on the ...
Source: Dr.S.Venkatesan MD - September 3, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
